Thiamine-triphosphatase: Difference between revisions
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{{enzyme |
{{enzyme |
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| Name = thiamin |
| Name = thiamin triphosphatase |
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| EC_number = 3.6.1.28 |
| EC_number = 3.6.1.28 |
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| CAS_number = 9068-47-7 |
| CAS_number = 9068-47-7 |
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|LocusSupplementaryData= |
|LocusSupplementaryData= |
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'''Thiamine triphosphatase''' is an [[acid anhydride hydrolase]] which acts upon [[thiamine triphosphate]]. In [[enzymology]], a '''thiamine |
'''Thiamine triphosphatase''' is an [[acid anhydride hydrolase]] which acts upon [[thiamine triphosphate]]. In [[enzymology]], a '''thiamine triphosphatase''' ({{EC number|3.6.1.28}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
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:thiamine triphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> thiamine diphosphate + phosphate |
:thiamine triphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> thiamine diphosphate + phosphate |
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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[thiamine triphosphate]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[thiamine diphosphate]] and [[phosphate]]. |
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[thiamine triphosphate]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[thiamine diphosphate]] and [[phosphate]]. |
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This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is '''thiamine |
This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is '''thiamine triphosphate phosphohydrolase'''. This enzyme participates in [[thiamine metabolism]]. |
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==Structural studies== |
==Structural studies== |
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Revision as of 14:22, 29 August 2011
| thiamin triphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.6.1.28 | ||||||||
| CAS no. | 9068-47-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| thiamine triphosphatase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | THTPA | ||||||
| NCBI gene | 79178 | ||||||
| HGNC | 18987 | ||||||
| RefSeq | NM_024328 | ||||||
| UniProt | Q9BU02 | ||||||
| Other data | |||||||
| EC number | 3.6.1.28 | ||||||
| Locus | Chr. 14 q11.2 | ||||||
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Thiamine triphosphatase is an acid anhydride hydrolase which acts upon thiamine triphosphate. In enzymology, a thiamine triphosphatase (EC 3.6.1.28) is an enzyme that catalyzes the chemical reaction
- thiamine triphosphate + H2O thiamine diphosphate + phosphate
Thus, the two substrates of this enzyme are thiamine triphosphate and H2O, whereas its two products are thiamine diphosphate and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is thiamine triphosphate phosphohydrolase. This enzyme participates in thiamine metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JMU.
References
- Hashitani Y, Cooper JR (1972). "The partial purification of thiamine triphosphatase from rat brain". J. Biol. Chem. 247 (7): 2117–9. PMID 4335862.
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