PSI-6130: Difference between revisions
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| IUPAC_name = 4-Amino-1-((2''R'',3''R'',4''R'',5''R'')-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1''H'')-one |
| IUPAC_name = 4-Amino-1-((2''R'',3''R'',4''R'',5''R'')-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1''H'')-one |
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| image = PSI-6130.png |
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Revision as of 20:41, 20 September 2011
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| Formula | C10H14FN3O4 |
| Molar mass | 259.23 g/mol g·mol−1 |
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PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors that was created by chemist Jeremy L. Clark.[1] Specifically, PSI-6130 inhibits the hepatitis C virus NS5B RNA dependant RNA polymerase.[2]
PSI-6130 is currently being developed by Hoffmann–La Roche as a 3',5'-diisobutyrl ester prodrug, R7128.[3] R7128 is part of the combination of all-oral agents clinical trial known as INFORM-1.[4][unreliable source?]
References
- ^ Clark, J.; et al. (2005). "Design, synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'C-methylcytidine, a potent inhibitor of hepatitis C virus replication". Journal of Medicinal Chemistry. 48 (17): 5504. doi:10.1021/jm0502788. PMID 16107149.
{{cite journal}}: Explicit use of et al. in:|author=(help) - ^ Lieven J Stuyver, Tamara R McBrayer, Phillip M Tharnish, Jeremy Clark, Laurent Hollecker; et al. (2006). "Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication". Antiviral Chemistry & Chemotherapy. 17 (2): 79–87.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ Cole, P.; Castaner, R.; Bolos, J. (2009). "R-7128: RNA-directed RNA polymerase (NS5B) inhibitor treatment of hepatitis C virus infection". Drugs of the Future. 34 (4): 282–290.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "INFORM-1 (R7227 and R7128) study".