Thyrotropin receptor: Difference between revisions
Content deleted Content added
m r2.7.1) (robot Adding: sv:Tyreotropinreceptorer |
m [Pu408]Tweak: title, issue. Formatted dashes. You can use this bot yourself. Report bugs here. |
||
| Line 1: | Line 1: | ||
{{Distinguish|Thyrotropin-releasing hormone|Thyrotropin-releasing hormone receptor}} |
{{Distinguish|Thyrotropin-releasing hormone|Thyrotropin-releasing hormone receptor}} |
||
{{PBB|geneid=7253}} |
{{PBB|geneid=7253}} |
||
The '''thyrotropin receptor''' (or '''TSH receptor''') is a receptor (and associated protein) that responds to [[thyroid-stimulating hormone]] (also known as "thyrotropin", and stimulates the production of [[thyroxine]] (T4) and [[triiodothyronine]] (T3). The TSH receptor is a member of the [[G protein-coupled receptor]] superfamily of [[integral membrane protein]]s<ref name="pmid15231707">{{cite journal | author = Farid NR, Szkudlinski MW | title = Minireview: structural and functional evolution of the thyrotropin receptor | journal = Endocrinology | volume = 145 | issue = 9 | pages = 4048–57 | year = 2004 | pmid = 15231707 | doi = 10.1210/en.2004-0437 |
The '''thyrotropin receptor''' (or '''TSH receptor''') is a receptor (and associated protein) that responds to [[thyroid-stimulating hormone]] (also known as "thyrotropin", and stimulates the production of [[thyroxine]] (T4) and [[triiodothyronine]] (T3). The TSH receptor is a member of the [[G protein-coupled receptor]] superfamily of [[integral membrane protein]]s<ref name="pmid15231707">{{cite journal | author = Farid NR, Szkudlinski MW | title = Minireview: structural and functional evolution of the thyrotropin receptor | journal = Endocrinology | volume = 145 | issue = 9 | pages = 4048–57 | year = 2004 | pmid = 15231707 | doi = 10.1210/en.2004-0437 }}</ref> and is coupled to the [[Gs_alpha_subunit|G<sub>s</sub>]] protein.<ref name="pmid20378719">{{cite journal | author = Calebiro D, Nikolaev VO, Lohse MJ | title = Imaging of persistent cAMP signaling by internalized G protein-coupled receptors | journal = J. Mol. Endocrinol. | volume = 45 | issue = 1 | pages = 1–8 | year = 2010 | month = July | pmid = 20378719 | doi = 10.1677/JME-10-0014 | url = }}</ref> |
||
It is primarily found on the surface of the [[thyroid epithelial cell]]s. |
It is primarily found on the surface of the [[thyroid epithelial cell]]s. |
||
| Line 23: | Line 23: | ||
*{{cite journal | author=Takeshita A, Nagayama Y, Fujiyama K, ''et al.'' |title=Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript. |journal=Biochem. Biophys. Res. Commun. |volume=188 |issue= 3 |pages= 1214–9 |year= 1992 |pmid= 1445355 |doi=10.1016/0006-291X(92)91360-3 }} |
*{{cite journal | author=Takeshita A, Nagayama Y, Fujiyama K, ''et al.'' |title=Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript. |journal=Biochem. Biophys. Res. Commun. |volume=188 |issue= 3 |pages= 1214–9 |year= 1992 |pmid= 1445355 |doi=10.1016/0006-291X(92)91360-3 }} |
||
*{{cite journal | author=Graves PN, Tomer Y, Davies TF |title=Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 2 |pages= 1135–43 |year= 1992 |pmid= 1530609 |doi=10.1016/0006-291X(92)91315-H }} |
*{{cite journal | author=Graves PN, Tomer Y, Davies TF |title=Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 2 |pages= 1135–43 |year= 1992 |pmid= 1530609 |doi=10.1016/0006-291X(92)91315-H }} |
||
*{{cite journal | author=Loosfelt H, Pichon C, Jolivet A, ''et al.'' |title=Two-subunit structure of the human thyrotropin receptor |
*{{cite journal | author=Loosfelt H, Pichon C, Jolivet A, ''et al.'' |title=Two-subunit structure of the human thyrotropin receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 9 |pages= 3765–9 |year= 1992 |pmid= 1570295 |doi=10.1073/pnas.89.9.3765 | pmc=525571 }} |
||
*{{cite journal | author=Nagayama Y, Russo D, Wadsworth HL, ''et al.'' |title=Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding |
*{{cite journal | author=Nagayama Y, Russo D, Wadsworth HL, ''et al.'' |title=Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding |journal=J. Biol. Chem. |volume=266 |issue= 23 |pages= 14926–30 |year= 1991 |pmid= 1651314 |doi= }} |
||
*{{cite journal | author=Murakami M, Mori M |title=Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease |
*{{cite journal | author=Murakami M, Mori M |title=Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease |journal=Biochem. Biophys. Res. Commun. |volume=171 |issue= 1 |pages= 512–8 |year= 1990 |pmid= 1697467 |doi=10.1016/0006-291X(90)91423-P }} |
||
*{{cite journal | author=Heldin NE, Gustavsson B, Westermark K, Westermark B |title=A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism |
*{{cite journal | author=Heldin NE, Gustavsson B, Westermark K, Westermark B |title=A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism |journal=J. Clin. Endocrinol. Metab. |volume=73 |issue= 6 |pages= 1374–6 |year= 1992 |pmid= 1955520 |doi=10.1210/jcem-73-6-1374 }} |
||
*{{cite journal | author=Libert F, Passage E, Lefort A, ''et al.'' |title=Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization |
*{{cite journal | author=Libert F, Passage E, Lefort A, ''et al.'' |title=Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=54 |issue= 1–2 |pages= 82–3 |year= 1991 |pmid= 2249482 |doi=10.1159/000132964 }} |
||
*{{cite journal | author=Frazier AL, Robbins LS, Stork PJ, ''et al.'' |title=Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing |
*{{cite journal | author=Frazier AL, Robbins LS, Stork PJ, ''et al.'' |title=Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing |journal=Mol. Endocrinol. |volume=4 |issue= 8 |pages= 1264–76 |year= 1991 |pmid= 2293030 |doi=10.1210/mend-4-8-1264 }} |
||
*{{cite journal | author=Misrahi M, Loosfelt H, Atger M, ''et al.'' |title=Cloning, sequencing and expression of human TSH receptor |
*{{cite journal | author=Misrahi M, Loosfelt H, Atger M, ''et al.'' |title=Cloning, sequencing and expression of human TSH receptor |journal=Biochem. Biophys. Res. Commun. |volume=166 |issue= 1 |pages= 394–403 |year= 1990 |pmid= 2302212 |doi=10.1016/0006-291X(90)91958-U }} |
||
*{{cite journal | author=Nagayama Y, Kaufman KD, Seto P, Rapoport B |title=Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor |
*{{cite journal | author=Nagayama Y, Kaufman KD, Seto P, Rapoport B |title=Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue= 3 |pages= 1184–90 |year= 1990 |pmid= 2558651 |doi=10.1016/0006-291X(89)92727-7 }} |
||
*{{cite journal | author=Libert F, Lefort A, Gerard C, ''et al.'' |title=Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies |
*{{cite journal | author=Libert F, Lefort A, Gerard C, ''et al.'' |title=Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue= 3 |pages= 1250–5 |year= 1990 |pmid= 2610690 |doi=10.1016/0006-291X(89)92736-8 }} |
||
*{{cite journal | author=Cuddihy RM, Bryant WP, Bahn RS |title=Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor |
*{{cite journal | author=Cuddihy RM, Bryant WP, Bahn RS |title=Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor |journal=Thyroid |volume=5 |issue= 4 |pages= 255–7 |year= 1996 |pmid= 7488864 |doi=10.1089/thy.1995.5.255 }} |
||
*{{cite journal | author=Bahn RS, Dutton CM, Heufelder AE, Sarkar G |title=A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy |
*{{cite journal | author=Bahn RS, Dutton CM, Heufelder AE, Sarkar G |title=A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy |journal=J. Clin. Endocrinol. Metab. |volume=78 |issue= 2 |pages= 256–60 |year= 1994 |pmid= 7508946 |doi=10.1210/jc.78.2.256 }} |
||
*{{cite journal | author=Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S |title=Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene |
*{{cite journal | author=Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S |title=Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene |journal=N. Engl. J. Med. |volume=332 |issue= 3 |pages= 155–60 |year= 1995 |pmid= 7528344 |doi=10.1056/NEJM199501193320305 }} |
||
}} |
}} |
||
{{refend}} |
{{refend}} |
||
Revision as of 08:03, 3 October 2011
Template:PBB The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin", and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins[1] and is coupled to the Gs protein.[2]
It is primarily found on the surface of the thyroid epithelial cells.
See also
References
- ^ Farid NR, Szkudlinski MW (2004). "Minireview: structural and functional evolution of the thyrotropin receptor". Endocrinology. 145 (9): 4048–57. doi:10.1210/en.2004-0437. PMID 15231707.
- ^ Calebiro D, Nikolaev VO, Lohse MJ (2010). "Imaging of persistent cAMP signaling by internalized G protein-coupled receptors". J. Mol. Endocrinol. 45 (1): 1–8. doi:10.1677/JME-10-0014. PMID 20378719.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
Further reading
External links
- "Glycoprotein Hormone Receptors: TSH". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
{{cite web}}: Cite has empty unknown parameter:|coauthors=(help) - Thyrotropin+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- GRIS: Glycoprotein-hormone Receptor Information System
 | This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it. |