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*{{cite journal | author=Catterall WA, Goldin AL, Waxman SG |title=International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 397–409 |year= 2006 |pmid= 16382098 |doi= 10.1124/pr.57.4.4 }}
*{{cite journal | author=Catterall WA, Goldin AL, Waxman SG |title=International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 397–409 |year= 2006 |pmid= 16382098 |doi= 10.1124/pr.57.4.4 }}
*{{cite journal | author=Lu CM, Han J, Rado TA, Brown GB |title=Differential expression of two sodium channel subtypes in human brain. |journal=FEBS Lett. |volume=303 |issue= 1 |pages= 53–8 |year= 1992 |pmid= 1317301 |doi=10.1016/0014-5793(92)80476-W }}
*{{cite journal | author=Lu CM, Han J, Rado TA, Brown GB |title=Differential expression of two sodium channel subtypes in human brain. |journal=FEBS Lett. |volume=303 |issue= 1 |pages= 53–8 |year= 1992 |pmid= 1317301 |doi=10.1016/0014-5793(92)80476-W }}
*{{cite journal | author=Ahmed CM, Ware DH, Lee SC, ''et al.'' |title=Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 17 |pages= 8220–4 |year= 1992 |pmid= 1325650 |doi=10.1073/pnas.89.17.8220 | pmc=49889 }}
*{{cite journal | author=Ahmed CM, Ware DH, Lee SC, ''et al.'' |title=Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 17 |pages= 8220–4 |year= 1992 |pmid= 1325650 |doi=10.1073/pnas.89.17.8220 | pmc=49889 }}
*{{cite journal | author=Han JA, Lu CM, Brown GB, Rado TA |title=Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 2 |pages= 335–9 |year= 1991 |pmid= 1846440 |doi=10.1073/pnas.88.2.335 | pmc=50805 }}
*{{cite journal | author=Han JA, Lu CM, Brown GB, Rado TA |title=Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 2 |pages= 335–9 |year= 1991 |pmid= 1846440 |doi=10.1073/pnas.88.2.335 | pmc=50805 }}
*{{cite journal | author=Litt M, Luty J, Kwak M, ''et al.'' |title=Localization of a human brain sodium channel gene (SCN2A) to chromosome 2. |journal=Genomics |volume=5 |issue= 2 |pages= 204–8 |year= 1989 |pmid= 2571571 |doi=10.1016/0888-7543(89)90047-5 }}
*{{cite journal | author=Litt M, Luty J, Kwak M, ''et al.'' |title=Localization of a human brain sodium channel gene (SCN2A) to chromosome 2 |journal=Genomics |volume=5 |issue= 2 |pages= 204–8 |year= 1989 |pmid= 2571571 |doi=10.1016/0888-7543(89)90047-5 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Lu CM, Eichelberger JS, Beckman ML, ''et al.'' |title=Isolation of the 5'-flanking region for human brain sodium channel subtype II alpha-subunit. |journal=J. Mol. Neurosci. |volume=11 |issue= 3 |pages= 179–82 |year= 1999 |pmid= 10344788 |doi=10.1385/JMN:11:3:179 }}
*{{cite journal | author=Lu CM, Eichelberger JS, Beckman ML, ''et al.'' |title=Isolation of the 5'-flanking region for human brain sodium channel subtype II alpha-subunit |journal=J. Mol. Neurosci. |volume=11 |issue= 3 |pages= 179–82 |year= 1999 |pmid= 10344788 |doi=10.1385/JMN:11:3:179 }}
*{{cite journal | author=Baulac S, Gourfinkel-An I, Picard F, ''et al.'' |title=A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33. |journal=Am. J. Hum. Genet. |volume=65 |issue= 4 |pages= 1078–85 |year= 2000 |pmid= 10486327 |doi=10.1086/302593 | pmc=1288241 }}
*{{cite journal | author=Baulac S, Gourfinkel-An I, Picard F, ''et al.'' |title=A Second Locus for Familial Generalized Epilepsy with Febrile Seizures Plus Maps to Chromosome 2q21-q33 |journal=Am. J. Hum. Genet. |volume=65 |issue= 4 |pages= 1078–85 |year= 2000 |pmid= 10486327 |doi=10.1086/302593 | pmc=1288241 }}
*{{cite journal | author=Schade SD, Brown GB |title=Identifying the promoter region of the human brain sodium channel subtype II gene (SCN2A). |journal=Brain Res. Mol. Brain Res. |volume=81 |issue= 1-2 |pages= 187–90 |year= 2001 |pmid= 11000491 |doi=10.1016/S0169-328X(00)00145-5 }}
*{{cite journal | author=Schade SD, Brown GB |title=Identifying the promoter region of the human brain sodium channel subtype II gene (SCN2A) |journal=Brain Res. Mol. Brain Res. |volume=81 |issue= 1–2 |pages= 187–90 |year= 2001 |pmid= 11000491 |doi=10.1016/S0169-328X(00)00145-5 }}
*{{cite journal | author=Kasai N, Fukushima K, Ueki Y, ''et al.'' |title=Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus. |journal=Gene |volume=264 |issue= 1 |pages= 113–22 |year= 2001 |pmid= 11245985 |doi=10.1016/S0378-1119(00)00594-1 }}
*{{cite journal | author=Kasai N, Fukushima K, Ueki Y, ''et al.'' |title=Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus |journal=Gene |volume=264 |issue= 1 |pages= 113–22 |year= 2001 |pmid= 11245985 |doi=10.1016/S0378-1119(00)00594-1 }}
*{{cite journal | author=Malacarne M, Gennaro E, Madia F, ''et al.'' |title=Benign familial infantile convulsions: mapping of a novel locus on chromosome 2q24 and evidence for genetic heterogeneity. |journal=Am. J. Hum. Genet. |volume=68 |issue= 6 |pages= 1521–6 |year= 2001 |pmid= 11326335 |doi=10.1086/320596 | pmc=1226140 }}
*{{cite journal | author=Malacarne M, Gennaro E, Madia F, ''et al.'' |title=Benign Familial Infantile Convulsions: Mapping of a Novel Locus on Chromosome 2q24 and Evidence for Genetic Heterogeneity |journal=Am. J. Hum. Genet. |volume=68 |issue= 6 |pages= 1521–6 |year= 2001 |pmid= 11326335 |doi=10.1086/320596 | pmc=1226140 }}
*{{cite journal | author=Sugawara T, Tsurubuchi Y, Agarwala KL, ''et al.'' |title=A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 11 |pages= 6384–9 |year= 2001 |pmid= 11371648 |doi= 10.1073/pnas.111065098 | pmc=33477 }}
*{{cite journal | author=Sugawara T, Tsurubuchi Y, Agarwala KL, ''et al.'' |title=A missense mutation of the Na+ channel αII subunit gene Nav1.2 in a patient with febrile and afebrile seizures causes channel dysfunction |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 11 |pages= 6384–9 |year= 2001 |pmid= 11371648 |doi= 10.1073/pnas.111065098 | pmc=33477 }}
*{{cite journal | author=Heron SE, Crossland KM, Andermann E, ''et al.'' |title=Sodium-channel defects in benign familial neonatal-infantile seizures. |journal=Lancet |volume=360 |issue= 9336 |pages= 851–2 |year= 2002 |pmid= 12243921 |doi=10.1016/S0140-6736(02)09968-3 }}
*{{cite journal | author=Heron SE, Crossland KM, Andermann E, ''et al.'' |title=Sodium-channel defects in benign familial neonatal-infantile seizures |journal=Lancet |volume=360 |issue= 9336 |pages= 851–2 |year= 2002 |pmid= 12243921 |doi=10.1016/S0140-6736(02)09968-3 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Weiss LA, Escayg A, Kearney JA, ''et al.'' |title=Sodium channels SCN1A, SCN2A and SCN3A in familial autism. |journal=Mol. Psychiatry |volume=8 |issue= 2 |pages= 186–94 |year= 2003 |pmid= 12610651 |doi= 10.1038/sj.mp.4001241 }}
*{{cite journal | author=Weiss LA, Escayg A, Kearney JA, ''et al.'' |title=Sodium channels SCN1A, SCN2A and SCN3A in familial autism |journal=Mol. Psychiatry |volume=8 |issue= 2 |pages= 186–94 |year= 2003 |pmid= 12610651 |doi= 10.1038/sj.mp.4001241 }}
*{{cite journal | author=Yu FH, Westenbroek RE, Silos-Santiago I, ''et al.'' |title=Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. |journal=J. Neurosci. |volume=23 |issue= 20 |pages= 7577–85 |year= 2003 |pmid= 12930796 |doi= }}
*{{cite journal | author=Yu FH, Westenbroek RE, Silos-Santiago I, ''et al.'' |title=Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2 |journal=J. Neurosci. |volume=23 |issue= 20 |pages= 7577–85 |year= 2003 |pmid= 12930796 |doi= }}
*{{cite journal | author=McEwen DP, Meadows LS, Chen C, ''et al.'' |title=Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 16044–9 |year= 2004 |pmid= 14761957 |doi= 10.1074/jbc.M400856200 }}
*{{cite journal | author=McEwen DP, Meadows LS, Chen C, ''et al.'' |title=Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 16044–9 |year= 2004 |pmid= 14761957 |doi= 10.1074/jbc.M400856200 }}
*{{cite journal | author=Kamiya K, Kaneda M, Sugawara T, ''et al.'' |title=A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline. |journal=J. Neurosci. |volume=24 |issue= 11 |pages= 2690–8 |year= 2004 |pmid= 15028761 |doi= 10.1523/JNEUROSCI.3089-03.2004 }}
*{{cite journal | author=Kamiya K, Kaneda M, Sugawara T, ''et al.'' |title=A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline |journal=J. Neurosci. |volume=24 |issue= 11 |pages= 2690–8 |year= 2004 |pmid= 15028761 |doi= 10.1523/JNEUROSCI.3089-03.2004 }}
*{{cite journal | author=Berkovic SF, Heron SE, Giordano L, ''et al.'' |title=Benign familial neonatal-infantile seizures: characterization of a new sodium channelopathy. |journal=Ann. Neurol. |volume=55 |issue= 4 |pages= 550–7 |year= 2004 |pmid= 15048894 |doi= 10.1002/ana.20029 }}
*{{cite journal | author=Berkovic SF, Heron SE, Giordano L, ''et al.'' |title=Benign familial neonatal-infantile seizures: characterization of a new sodium channelopathy |journal=Ann. Neurol. |volume=55 |issue= 4 |pages= 550–7 |year= 2004 |pmid= 15048894 |doi= 10.1002/ana.20029 }}
*{{cite journal | author=Pereira S, Vieira JP, Barroca F, ''et al.'' |title=Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A. |journal=Neurology |volume=63 |issue= 1 |pages= 191–2 |year= 2004 |pmid= 15249644 |doi= }}
*{{cite journal | author=Pereira S, Vieira JP, Barroca F, ''et al.'' |title=Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A |journal=Neurology |volume=63 |issue= 1 |pages= 191–2 |year= 2004 |pmid= 15249644 |doi= }}
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Revision as of 01:22, 8 October 2011

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Navα1.2, also known as the sodium channel, voltage-gated, type II, alpha subunit is a protein that in humans is encoded by the SCN2A gene.[1] Functional sodium channels contain an ion conductive alpha subunit and one or more regulatory beta subunits. Sodium channels which contain the Navα1.2 subunit are called Nav1.2 channels.

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See also

References

  1. ^ Cite error: The named reference entrez was invoked but never defined (see the help page).

Further reading

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