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Senna is on the [[World Health Organization]]'s [[List of World Health Organization Essential Medicines|list of essential medicines]].
Senna is on the [[World Health Organization]]'s [[List of World Health Organization Essential Medicines|list of essential medicines]].


'''Indications'''

Many people use sennosides (brand name: Senokot) to relieve functional or drug-induced constipation. Sennosides are stimulant laxatives; they work by stimulating contractions of the smooth muscle surrounding the colon. Sennosides have no effect on other muscles, as sennosides are activated exclusively by colonic bacteria.

'''Side Effects'''

Sennosides may cause griping. Sennosides, like other stimulant laxatives, may cause "laxative addiction" if used too often. Although pyllium fiber is the laxative-of-choice for pregnant and breast-feeding women, they are safe for pregnant and breast-feeding women.

'''Drug Interactions'''
Sennosides do not interact with other medications directly. However, by altering the behavior of the colon, sennosides may change the aborption of other drugs.




==External links==
==External links==
*[http://pharmasight.org/overthecounter/2011/11/13/remedies-for-constipation-sennosides-senokot/ Remedies for Constipation: sennosides (Senokot)]
* {{cite journal |author=Vanderperren B, Rizzo M, Angenot L, Haufroid V, Jadoul M, Hantson P |title=Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides |journal=The Annals of pharmacotherapy |volume=39 |issue=7–8 |pages=1353–7 |year=2005 |pmid=15956233 |doi=10.1345/aph.1E670}}
* {{cite journal |author=Vanderperren B, Rizzo M, Angenot L, Haufroid V, Jadoul M, Hantson P |title=Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides |journal=The Annals of pharmacotherapy |volume=39 |issue=7–8 |pages=1353–7 |year=2005 |pmid=15956233 |doi=10.1345/aph.1E670}}
* {{cite journal |author=Mereto E, Ghia M, Brambilla G |title=Evaluation of the potential carcinogenic activity of Senna and Cascara glycosides for the rat colon |journal=Cancer Lett. |volume=101 |issue=1 |pages=79–83 |year=1996 |pmid=8625286 |doi=10.1016/0304-3835(96)04129-8}}
* {{cite journal |author=Mereto E, Ghia M, Brambilla G |title=Evaluation of the potential carcinogenic activity of Senna and Cascara glycosides for the rat colon |journal=Cancer Lett. |volume=101 |issue=1 |pages=79–83 |year=1996 |pmid=8625286 |doi=10.1016/0304-3835(96)04129-8}}

Revision as of 10:10, 15 November 2011

Senna glycoside
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Senna glycosides or sennosides are a number of anthraquinone derivatives useful as a laxative. They are dimeric glycosides named after their abundant occurrence in plants of the genus Senna.

Senna is on the World Health Organization's list of essential medicines.

Indications

Many people use sennosides (brand name: Senokot) to relieve functional or drug-induced constipation. Sennosides are stimulant laxatives; they work by stimulating contractions of the smooth muscle surrounding the colon. Sennosides have no effect on other muscles, as sennosides are activated exclusively by colonic bacteria.

Side Effects

Sennosides may cause griping. Sennosides, like other stimulant laxatives, may cause "laxative addiction" if used too often. Although pyllium fiber is the laxative-of-choice for pregnant and breast-feeding women, they are safe for pregnant and breast-feeding women.

Drug Interactions Sennosides do not interact with other medications directly. However, by altering the behavior of the colon, sennosides may change the aborption of other drugs.


  • Remedies for Constipation: sennosides (Senokot)
  • Vanderperren B, Rizzo M, Angenot L, Haufroid V, Jadoul M, Hantson P (2005). "Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides". The Annals of pharmacotherapy. 39 (7–8): 1353–7. doi:10.1345/aph.1E670. PMID 15956233.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Mereto E, Ghia M, Brambilla G (1996). "Evaluation of the potential carcinogenic activity of Senna and Cascara glycosides for the rat colon". Cancer Lett. 101 (1): 79–83. doi:10.1016/0304-3835(96)04129-8. PMID 8625286.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • http://chemicalland21.com/lifescience/phar/CALCIUM%20SENNOSIDE.htm