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[[Category:Thyroid disease]]
[[Category:Thyroid disease]]
[[Category:Symptoms and signs: Endocrinology, nutrition, and metabolism]]
[[Category:Symptoms and signs: Endocrinology, nutrition, and metabolism]]

[[nl:Teken van Hertoghe]]

Revision as of 10:35, 5 December 2011

The Sign of Hertoghe or Queen Anne's sign is a thinning or loss of the outer third of the eyebrows, and is a sign of hypothyroidism.

The sign is named for Eugene Hertoghe of Antwerp, a pioneer in thyroid function research.[1][2]

Queen Anne's sign

Anne of Denmark mourning the death of her son Henry in 1612

The association with Anne of Denmark is based on portraiture, and history does not suggest that she suffered an underactive thyroid.[3] The eponym is disputed by some, though it has been suggested that Anne of France, Anne of Brittany, Anne of Austria, Anne Boleyn and Anne of Cleves may all be eliminated as candidates.[4]

References

  1. ^ Schatz, Henry A. (1922-05). "The Role of the Thyroid Gland in Otolaryngology". The Pennsylvania Medical Journal. 25 (8): 529. {{cite journal}}: |access-date= requires |url= (help); Check date values in: |date= (help); Cite has empty unknown parameter: |coauthors= (help)
  2. ^ "Complimentary Dinner given by Dr. William Seaman Bainbridge". American Medicine. 9 (4): 308. 1914-04. {{cite journal}}: |access-date= requires |url= (help); |first= has generic name (help); |first= missing |last= (help); Check date values in: |date= (help); Cite has empty unknown parameter: |coauthors= (help)
  3. ^ Lane Furdell E (2007). "Eponymous, anonymous: Queen Anne's sign and the misnaming of a symptom". J Med Biogr. 15 (2): 97–101. PMID 17551609. {{cite journal}}: Unknown parameter |month= ignored (help)
  4. ^ Keynes M (2009). "Letter to the editor". J Med Biogr. 17 (1): 62. doi:10.1258/jmb.2007.007021. PMID 19190203. {{cite journal}}: Unknown parameter |month= ignored (help)

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