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[[Image:Glioblastoma with extreme nuclear enlargement - very high mag.jpg|thumb|[[Micrograph]] showing extreme nuclear atypia in [[cancer]] ([[glioblastoma]]). [[Brain biopsy]]. [[HPS stain]].]]
'''Nuclear atypia''' refers to abnormal appearance of [[cell nucleus|cell nuclei]]. It is a term used in [[cytopathology]]. Specific abnormalities include [[pleomorphism (cytology)|pleomorphism]].
'''Nuclear atypia''' refers to abnormal appearance of [[cell nucleus|cell nuclei]]. It is a term used in [[cytopathology]] and [[histopathology]]. Atypical nuclei are often [[pleomorphism (cytology)|pleomorphic]].

Nuclear atypia can be seen in reactive changes, pre-neoplastic changes and [[malignancy]]. Severe nuclear atypia is, in most cases, considered an indicator of [[malignancy]].





Revision as of 03:41, 14 December 2011

Micrograph showing extreme nuclear atypia in cancer (glioblastoma). Brain biopsy. HPS stain.

Nuclear atypia refers to abnormal appearance of cell nuclei. It is a term used in cytopathology and histopathology. Atypical nuclei are often pleomorphic.

Nuclear atypia can be seen in reactive changes, pre-neoplastic changes and malignancy. Severe nuclear atypia is, in most cases, considered an indicator of malignancy.