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'''Nuclear atypia''' refers to abnormal appearance of [[cell nucleus|cell nuclei]]. It is a term used in [[cytopathology]] and [[histopathology]]. Atypical nuclei are often [[pleomorphism (cytology)|pleomorphic]].
'''Nuclear atypia''' refers to abnormal appearance of [[cell nucleus|cell nuclei]]. It is a term used in [[cytopathology]] and [[histopathology]]. Atypical nuclei are often [[pleomorphism (cytology)|pleomorphic]].


Nuclear atypia can be seen in reactive changes, pre-neoplastic changes and [[malignancy]]. Severe nuclear atypia is, in most cases, considered an indicator of [[malignancy]].
Nuclear atypia can be seen in reactive changes, [[Precancerous condition|pre-neoplastic changes]] and [[malignancy]]. Severe nuclear atypia is, in most cases, considered an indicator of [[malignancy]].





Revision as of 03:43, 14 December 2011

Micrograph showing extreme nuclear atypia in cancer (glioblastoma). Brain biopsy. HPS stain.

Nuclear atypia refers to abnormal appearance of cell nuclei. It is a term used in cytopathology and histopathology. Atypical nuclei are often pleomorphic.

Nuclear atypia can be seen in reactive changes, pre-neoplastic changes and malignancy. Severe nuclear atypia is, in most cases, considered an indicator of malignancy.