Cortisone: Difference between revisions
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==History== |
==History== |
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Cortisone was first identified by the American chemist [[Edward Calvin Kendall]] while a researcher at the [[Mayo Clinic]].<ref name="urlCortisone Discovery and the Nobel Prize">{{cite web |url=http://www.mayoclinic.org/tradition-heritage/cortisone-discovery.html |title=Cortisone Discovery and the Nobel Prize |work= |accessdate=2009-07-04}}</ref> He was awarded the 1950 [[Nobel Prize for Physiology or Medicine]] along with [[Philip S. Hench]] and [[Tadeus Reichstein]] for the discovery of [[adrenal cortex]] hormones, their structures, and their functions. Cortisone was first produced commercially by [[Merck & Co.]] On September 30, 1949, [[Percy Lavon Julian|Percy Julian]] announced an improvement in the process of producing cortisone from [[bile acid]]s.{{Time fact|date=September 2011}} This eliminated the need to use [[osmium tetroxide]], a rare, expensive, and dangerous chemical. |
Cortisone was first identified by the American chemist [[Edward Calvin Kendall]] while a researcher at the [[Mayo Clinic]].<ref name="urlCortisone Discovery and the Nobel Prize">{{cite web |url=http://www.mayoclinic.org/tradition-heritage/cortisone-discovery.html |title=Cortisone Discovery and the Nobel Prize |work= |accessdate=2009-07-04}}</ref> He was awarded the 1950 [[Nobel Prize for Physiology or Medicine]] along with [[Philip S. Hench]] and [[Tadeus Reichstein]] for the discovery of [[adrenal cortex]] hormones, their structures, and their functions. Cortisone was first produced commercially by [[Merck & Co.]] On September 30, 1949, [[Percy Lavon Julian|Percy Julian]] announced an improvement in the process of producing cortisone from [[bile acid]]s.{{Time fact|date=September 2011}} This eliminated the need to use [[osmium tetroxide]], a rare, expensive, and dangerous chemical. Unknown at the time of the [[United States presidential election, 1960 | 1960 Presidential election]], President [[John F. Kennedy]] took Cortisone supplements to counter the adrenal deficiency symptoms of [[Addison's Disease]], which he denied having.<ref>http://www.pbs.org/newshour/character/essays/kennedy.html</ref><ref>http://www.nytimes.com/1992/10/06/health/the-doctor-s-world-disturbing-issue-of-kennedy-s-secret-illness.html?pagewanted=all&src=pm</ref> |
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==Production== |
==Production== |
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Revision as of 06:39, 29 February 2012
 | This article's lead section may be too short to adequately summarize the key points. (November 2009) |
 | This article needs additional citations for verification. (December 2008) |
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| Names | |
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| IUPAC name
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
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| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.000.149 |
| KEGG | |
| MeSH | Cortisone |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C21H28O5 | |
| Molar mass | 376.0g/mol |
| Melting point | 220–224 °C |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Cortisone (/[invalid input: 'icon']ˈkɔːrt[invalid input: 'ɨ']soʊn/ or /ˈkɔːrt[invalid input: 'ɨ']zoʊn/; 17-hydroxy-11-dehydrocorticosterone) is a steroid hormone. It is one of the main hormones released by the adrenal gland in response to stress. In chemical structure, it is a corticosteroid closely related to corticosterone. It is used to treat a variety of ailments and can be administered intravenously, orally, intraarticularly, or transcutaneously. Cortisone suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury. Risks exist, in particular in the long-term use of cortisone.[1][2]
History
Cortisone was first identified by the American chemist Edward Calvin Kendall while a researcher at the Mayo Clinic.[3] He was awarded the 1950 Nobel Prize for Physiology or Medicine along with Philip S. Hench and Tadeus Reichstein for the discovery of adrenal cortex hormones, their structures, and their functions. Cortisone was first produced commercially by Merck & Co. On September 30, 1949, Percy Julian announced an improvement in the process of producing cortisone from bile acids.[chronology citation needed] This eliminated the need to use osmium tetroxide, a rare, expensive, and dangerous chemical. Unknown at the time of the 1960 Presidential election, President John F. Kennedy took Cortisone supplements to counter the adrenal deficiency symptoms of Addison's Disease, which he denied having.[4][5]
Production
Cortisone is one of several end-products of a process called steroidogenesis. This process starts with the synthesis of cholesterol, which then proceeds through a series of modifications in the adrenal gland (suprarenal) to become any one of many steroid hormones. One end-product of this pathway is cortisol. For cortisol to be released from the adrenal gland, a cascade of signaling occurs. Corticotropin-releasing hormone released from the hypothalamus stimulates corticotrophs in the anterior pituitary to release ACTH, which relays the signal to the adrenal cortex. Here, the zona fasciculata and zona reticularis, in response to ACTH, secrete glucocorticoids, in particular cortisol. In the peripheral tissues, cortisol is converted to cortisone by the enzyme 11-beta-steroid dehydrogenase. Cortisol has much greater glucocorticoid activity than cortisone, and, thus, cortisone can be considered an inactive metabolite of cortisol. However, 11-beta-steroid dehydrogenase can catalyze the reverse reaction as well, and, thus, cortisone is also the inactive precursor molecule of the active hormone cortisol. Cortisone is activated through hydrogenation of the 11-keto-group, and cortisol is, thus, sometimes referred to as hydrocortisone.[6]
Effects and uses
Cortisone, a glucocorticoid, and adrenaline are the main hormones released by the body as a reaction to stress. They elevate blood pressure and prepare the body for a fight or flight response.
A cortisone injection can also be used to give short-term pain relief and reduce the swelling from inflammation of a joint, tendon, or bursa in, for example, the joints of the knee, elbow, and shoulder.[7]
Cortisone may also be used to deliberately suppress immune response in persons with autoimmune diseases or following an organ transplant to prevent transplant rejection. The suppression of the immune system may also be important in the treatment of inflammatory conditions such as severe IgE-mediated allergies.[8]
Last, cortisone is a common treatment for a severe sore throat that occurs commonly with EBV infectious mononucleosis. It is important to note that cortisone does not help lessen the duration of the virus, and is used purely to increase the comfort of a patient with trouble speaking or swallowing as a result of the mononucleosis-induced swollen throat.
Side-effects
Oral use of cortisone has a number of potential side-effects: hyperglycemia, insulin resistance, diabetes mellitus, osteoporosis, anxiety, depression, amenorrhoea, cataracts and glaucoma, among other problems.[1][2][citation needed]
See also
References
Notes
- ^ a b "Cortisone shots: Risks". MayoClinic.com. 2010-11-16. Retrieved 2011-09-03.
- ^ a b "Prednisone and other corticosteroids: Balance the risks and benefits". MayoClinic.com. 2010-06-05. Retrieved 2011-09-03.
- ^ "Cortisone Discovery and the Nobel Prize". Retrieved 2009-07-04.
- ^ http://www.pbs.org/newshour/character/essays/kennedy.html
- ^ http://www.nytimes.com/1992/10/06/health/the-doctor-s-world-disturbing-issue-of-kennedy-s-secret-illness.html?pagewanted=all&src=pm
- ^ Samuels, Theophilus "Cortisol vs. corticosterone"
- ^ [1][dead link]
- ^ "Cortisol vs. corticosterone". Bio.net. Retrieved 2011-09-03.
Bibliography
- Bonagura J., DVM.; et al. (2000). Current Veterinary Therapy. Vol. 13. pp. 321–381.
{{cite book}}: Explicit use of et al. in:|author=(help) - Ingle DJ (1950). "The biologic properties of cortisone: a review". J. Clin. Endocrinol. Metab. 10 (10): 1312–54. doi:10.1210/jcem-10-10-1312. PMID 14794756.
{{cite journal}}: Unknown parameter|month=ignored (help) - Woodward R. B., Sondheimer F., Taub D. (1951). "The Total Synthesis of Cortisone". Journal of the American Chemical Society. 73 (8): 4057–4057. doi:10.1021/ja01152a551.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- Cortisone: The Wonder Drug
- "How Hormone Team Is Saving Lives" , by John E. Pleiffer 1951 article on the new drug cortisone and how it works