RGS12: Difference between revisions

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Template:PBB Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.^[1]^[2]

Template:PBB Summary

Interactions

RGS12 has been shown to interact with GNAI1^[3] and GNAI3.^[3]

References

^ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: RGS12 regulator of G-protein signalling 12".
^ ^a ^b Kimple, R J (2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31). United States: 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)

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 {{PBB|geneid=6002}}
-'''Regulator of G-protein signaling 12''' is a [[protein]] that in humans is encoded by the ''RGS12'' [[gene]].<ref name="pmid9651375">{{cite journal | author = Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP | title = GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain | journal = J Biol Chem | volume = 273 | issue = 28 | pages = 17749–55 | year = 1998 | month = Aug | pmid = 9651375 | pmc =  | doi =10.1074/jbc.273.28.17749  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS12 regulator of G-protein signalling 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6002| accessdate = }}</ref>
+'''Regulator of G-protein signaling 12''' is a [[protein]] that in humans is encoded by the ''RGS12'' [[gene]].<ref name="pmid9651375">{{cite journal | author = Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP | title = GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain | journal = J Biol Chem | volume = 273 | issue = 28 | pages = 17749–55 | year = 1998 | month = August | pmid = 9651375 | pmc =  | doi =10.1074/jbc.273.28.17749  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS12 regulator of G-protein signalling 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6002| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: RGS12 regulator of G-protein signalling 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6002| accessdate = }}</ref>
+| summary_text = This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.<ref name="entrez"/>
 }}
 ==Interactions==
-RGS12 has been shown to [[Protein-protein_interaction|interact]] with [[GNAI1]]<ref name=pmid11387333>{{cite journal |last=Kimple |first=R J |authorlink= |coauthors=De Vries L, Tronchère H, Behe C I, Morris R A, Gist Farquhar M, Siderovski D P |year=[[2001]]|month=Aug. |title=RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity |journal=J. Biol. Chem. |volume=276 |issue=31 |pages=29275–81 |publisher= |location = United States| issn = 0021-9258| pmid = 11387333 |doi = 10.1074/jbc.M103208200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[GNAI3]].<ref name=pmid11387333/>
+RGS12 has been shown to [[Protein-protein interaction|interact]] with [[GNAI1]]<ref name=pmid11387333>{{cite journal |last=Kimple |first=R J |authorlink= |coauthors=De Vries L, Tronchère H, Behe C I, Morris R A, Gist Farquhar M, Siderovski D P |year=2001|month=August |title=RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity |journal=J. Biol. Chem. |volume=276 |issue=31 |pages=29275–81 |publisher= |location = United States| issn = 0021-9258| pmid = 11387333 |doi = 10.1074/jbc.M103208200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[GNAI3]].<ref name=pmid11387333/>
 ==References==
-{{reflist}}
+{{Reflist}}
 ==Further reading==
-{{refbegin | 2}}
+{{Refbegin | 2}}
 {{PBB_Further_reading
 | citations =
 *{{cite journal  | author=Frohme M, Scharm B, Delius H, ''et al.'' |title=Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue. |journal=Ann. N. Y. Acad. Sci. |volume=910 |issue=  |pages= 85–104; discussion 104–5 |year= 2000 |pmid= 10911908 |doi=10.1111/j.1749-6632.2000.tb06703.x  }}
 *{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
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 *{{cite journal  | author=Yang S, Li YP |title=RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro. |journal=J. Bone Miner. Res. |volume=22 |issue= 1 |pages= 45–54 |year= 2007 |pmid= 17042716 |doi= 10.1359/jbmr.061007 }}
 }}
-{{refend}}
+{{Refend}}
-{{gene-4-stub}}
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+{{Gene-4-stub}}