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SNORD111 belongs to the [[SnoRNA#C.2FD_box|C/D box]] class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-[[methylation]] of substrate RNAs.<ref>{{cite journal |author= Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I; |title= Purified box C/D snoRNPs are able to reproduce site-specific2'-O-methylation of target RNA in vitro. |journal= Mol Cell Biol |volume= 22 |issue= |pages= 6663–6668 |year= 2002 |pmid=12215523 |doi= 10.1128/MCB.22.19.6663-6668.2002 |pmc=134041}}</ref> SNORD111 is predicted to guide the 2'O-ribose methylation of 28S [[ribosomal RNA]] (rRNA) at residue G3923.<ref>{{cite journal |author= Lestrade L, Weber MJ; |title= snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs. |journal= Nucleic Acids Res |volume= 34 |issue= |pages= D158–D162 |year= 2006 |pmid=16381836 |doi= 10.1093/nar/gkj002 |pmc=1347365}}</ref><ref name="pmid11387227">{{cite journal |author=Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J |title=RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. |journal=EMBO J |volume=20 |issue=11 |pages=2943–53 |year=2001 |pmid=11387227 |doi=10.1093/emboj/20.11.2943 |pmc=125495}}</ref>
SNORD111 belongs to the [[SnoRNA#C.2FD_box|C/D box]] class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-[[methylation]] of substrate RNAs.<ref>{{cite journal |author= Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I; |title= Purified box C/D snoRNPs are able to reproduce site-specific2'-O-methylation of target RNA in vitro. |journal= Mol Cell Biol |volume= 22 |issue= |pages= 6663–6668 |year= 2002 |pmid=12215523 |doi= 10.1128/MCB.22.19.6663-6668.2002 |pmc=134041}}</ref> SNORD111 is predicted to guide the 2'O-ribose methylation of 28S [[ribosomal RNA]] (rRNA) at residue G3923.<ref>{{cite journal |author= Lestrade L, Weber MJ; |title= snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs. |journal= Nucleic Acids Res |volume= 34 |issue= |pages= D158–D162 |year= 2006 |pmid=16381836 |doi= 10.1093/nar/gkj002 |pmc=1347365}}</ref><ref name="pmid11387227">{{cite journal |author=Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J |title=RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. |journal=EMBO J |volume=20 |issue=11 |pages=2943–53 |year=2001 |pmid=11387227 |doi=10.1093/emboj/20.11.2943 |pmc=125495}}</ref>
It is important to note that the role of these molecules is not known, and as such they present a very promising future in clinical biochemical research.
The exact role of these molecules, however, is not currently known.

==References==
==References==


Revision as of 13:19, 14 May 2012

Small Nucleolar RNA SNORD111
Predicted secondary structure and sequence conservation of SNORD111
Identifiers
SymbolSNORD111
RfamRF00611
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

Small Nucleolar RNA SNORD111 (also known as HBII-82) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNORD111 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] SNORD111 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) at residue G3923.[2][3] The exact role of these molecules, however, is not currently known.

References

  1. ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I; (2002). "Purified box C/D snoRNPs are able to reproduce site-specific2'-O-methylation of target RNA in vitro". Mol Cell Biol. 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.{{cite journal}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)
  2. ^ Lestrade L, Weber MJ; (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs". Nucleic Acids Res. 34: D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.{{cite journal}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)
  3. ^ Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.{{cite journal}}: CS1 maint: multiple names: authors list (link)



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