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==Interactions==
==Interactions==
ARHGEF1 has been shown to [[Protein-protein_interaction|interact]] with [[GNA13]],<ref name=pmid14634662><div class='references-small'> </div> </ref><ref name=pmid12681510>{{cite journal |last=Bhattacharyya |first=Raja |authorlink= |coauthors=Wedegaertner Philip B |year=[[2003]]|month=Apr. |title=Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment |journal=FEBS Lett. |volume=540 |issue=1–3 |pages=211–6 |publisher= |location = Netherlands| issn = 0014-5793| pmid = 12681510 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0014-5793(03)00267-9 }}</ref><ref name=pmid9641916>{{cite journal |last=Hart |first=M J |authorlink= |coauthors=Jiang X, Kozasa T, Roscoe W, Singer W D, Gilman A G, Sternweis P C, Bollag G |year=[[1998]]|month=Jun. |title=Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13 |journal=[[Science (journal)|Science]] |volume=280 |issue=5372 |pages=2112–4 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 9641916 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1126/science.280.5372.2112 |unused_data=DUPLICATE DATA: pmid = 9669963 }}</ref> [[CD44]],<ref name="pmid14634662" /> [[P110α]]<ref name=pmid12754211>{{cite journal |last=Holinstat |first=Michael |authorlink= |coauthors=Mehta Dolly, Kozasa Tohru, Minshall Richard D, Malik Asrar B |year=[[2003]]|month=Aug. |title=Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement |journal=J. Biol. Chem. |volume=278 |issue=31 |pages=28793–8 |publisher= |location = United States| issn = 0021-9258| pmid = 12754211 |doi = 10.1074/jbc.M303900200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[GNA12]].<ref name=pmid14634662/>
ARHGEF1 has been shown to [[Protein-protein_interaction|interact]] with [[GNA13]],<ref name=pmid14634662><div class='references-small'> </div> </ref><ref name=pmid12681510>{{cite journal |last=Bhattacharyya |first=Raja |authorlink= |coauthors=Wedegaertner Philip B |year=[[2003]]|month=Apr. |title=Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment |journal=FEBS Lett. |volume=540 |issue=1–3 |pages=211–6 |publisher= |location = Netherlands| issn = 0014-5793| pmid = 12681510 |doi=10.1016/S0014-5793(03)00267-9 }}</ref><ref name=pmid9641916>{{cite journal |last=Hart |first=M J |authorlink= |coauthors=Jiang X, Kozasa T, Roscoe W, Singer W D, Gilman A G, Sternweis P C, Bollag G |year=[[1998]]|month=Jun. |title=Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13 |journal=[[Science (journal)|Science]] |volume=280 |issue=5372 |pages=2112–4 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 9641916 |doi=10.1126/science.280.5372.2112 }}</ref> [[CD44]],<ref name="pmid14634662" /> [[P110α]]<ref name=pmid12754211>{{cite journal |last=Holinstat |first=Michael |authorlink= |coauthors=Mehta Dolly, Kozasa Tohru, Minshall Richard D, Malik Asrar B |year=[[2003]]|month=Aug. |title=Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement |journal=J. Biol. Chem. |volume=278 |issue=31 |pages=28793–8 |publisher= |location = United States| issn = 0021-9258| pmid = 12754211 |doi = 10.1074/jbc.M303900200 }}</ref> and [[GNA12]].<ref name=pmid14634662/>


==References==
==References==

Revision as of 06:47, 16 July 2012

Template:PBB Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.[1][2][3]


Template:PBB Summary

Interactions

ARHGEF1 has been shown to interact with GNA13,[4][5][6] CD44,[4] P110α[7] and GNA12.[4]

References

  1. ^ Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, Bollag G (1996). "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase". J Biol Chem. 271 (41): 25452–8. doi:10.1074/jbc.271.41.25452. PMID 8810315. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  2. ^ Aasheim HC, Pedeutour F, Smeland EB (1997). "Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues". Oncogene. 14 (14): 1747–52. doi:10.1038/sj.onc.1200994. PMID 9135076. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ "Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1".
  4. ^ a b c
  5. ^ Bhattacharyya, Raja (2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. 540 (1–3). Netherlands: 211–6. doi:10.1016/S0014-5793(03)00267-9. ISSN 0014-5793. PMID 12681510. {{cite journal}}: Check date values in: |year= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  6. ^ Hart, M J (1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science. 280 (5372). UNITED STATES: 2112–4. doi:10.1126/science.280.5372.2112. ISSN 0036-8075. PMID 9641916. {{cite journal}}: Check date values in: |year= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  7. ^ Holinstat, Michael (2003). "Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement". J. Biol. Chem. 278 (31). United States: 28793–8. doi:10.1074/jbc.M303900200. ISSN 0021-9258. PMID 12754211. {{cite journal}}: Check date values in: |year= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)

Further reading

Template:PBB Further reading

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