Mannich base: Difference between revisions
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A '''mannich base''' is a beta-[[amine|amino]]-[[ketone]], which is formed in the reaction of an [[amine]], [[formaldehyde]] (or an [[aldehyde]]) and a [[carbon acid]] |
A '''mannich base''' is a beta-[[amine|amino]]-[[ketone]], which is formed in the reaction of an [[amine]], [[formaldehyde]] (or an [[aldehyde]]) and a [[carbon acid]].<ref>{{JerryMarch}}</ref> The Mannich base is an endproduct in the [[Mannich reaction]], which is [[nucleophilic]] [[addition reaction]] of a [[enol|non-enolizable]] aldehyde and any primary or secondary [[amine]] to produce resonance stabilized [[imine]] (iminium ion or imine salt). The addition of a carbanion from a CH acidic compound (any enolizable carbonyl compound, amide, carbamate, hydantoin or urea) to the imine gives the Mannich base.<ref>Mannich base applied in this example: {{cite journal | author = V. J. Belinelo, G. T. Reis, G. M. Stefani, D. L. Ferreira-Alves and D. Piló-Veloso | title = Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation | year = 2002 | journal = [[Journal of the Brazilian Chemical Society]] | volume = 13 | issue = 6| pages = 830–837 | url = http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600016&nrm=iso | format = [[Open access (publishing)|open access]] | doi = 10.1590/S0103-50532002000600016}}</ref> |
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:[[Image:MannichBase forrmation base catalysed.svg|Base catalysed Mannich reaction forming Mannich base]] |
:[[Image:MannichBase forrmation base catalysed.svg|Base catalysed Mannich reaction forming Mannich base]] |
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Revision as of 10:39, 12 October 2012
A mannich base is a beta-amino-ketone, which is formed in the reaction of an amine, formaldehyde (or an aldehyde) and a carbon acid.[1] The Mannich base is an endproduct in the Mannich reaction, which is nucleophilic addition reaction of a non-enolizable aldehyde and any primary or secondary amine to produce resonance stabilized imine (iminium ion or imine salt). The addition of a carbanion from a CH acidic compound (any enolizable carbonyl compound, amide, carbamate, hydantoin or urea) to the imine gives the Mannich base.[2]
Reactivity
With primary or secondary amines, Mannich bases react with additional aldehyde and carbon acid to larger adducts HN(CH2CH2COR)2 and HN(CH2CH2COR)2. With multiple acidic hydrogen atoms on the carbon acid higher adducts are also possible. Ammonia can be split off in an elimination reaction to form enals and enones.
References
- ^ March, Jerry (1985). Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (3rd ed.). New York: Wiley. ISBN 9780471854722. OCLC 642506595.
- ^ Mannich base applied in this example: V. J. Belinelo, G. T. Reis, G. M. Stefani, D. L. Ferreira-Alves and D. Piló-Veloso (2002). "Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation" (open access). Journal of the Brazilian Chemical Society. 13 (6): 830–837. doi:10.1590/S0103-50532002000600016.
{{cite journal}}: CS1 maint: multiple names: authors list (link)