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Alkaline tide refers to a condition, normally encountered after eating a meal, where during the production of HCl by parietal cells in the stomach leads the parietal cells also secreting bicarbonate ions across their basolateral membrane and into the interstitial fluid causing a temporary increase in pH.

During hydrochloric acid secretion in the stomach, the gastric parietal cells extract chloride anions, carbon dioxide, water and sodium cations from the blood plasma and in turn release bicarbonate back into the plasma after the hydrochloric acid is formed from carbon dioxide and water constituents. This is to maintain the plasma's electrical balance, as the chloride anions have been extracted. The bicarbonate content causes the venous blood leaving the stomach to be more alkaline than the arterial blood delivered to it.

Post-prandial (i.e., after a meal) alkaline tide lasts until the acids in food absorbed in the small intestine reunite with the bicarbonate that was produced when the food was in the stomach. Thus, alkaline tide is self-limited and normally lasts less than two hours.

Post-prandial alkaline tide has also been shown to be a causative agent of calcium oxalate urinary stones in cats,^[1] and potentially in other species^[2]

A more pronounced alkaline tide results from vomiting, which stimulates hyperactivity of gastric parietal cells to replace lost stomach acid (verification needed). Thus, protracted vomiting can result in metabolic alkalosis.^{[citation needed]}

References

^ Taton DF, Hamar D, Lewis LD. Evaluation of ammonium chloride as a urinary acidifier in the cat. Journal of the American Veterinary Medical Association 1984; 184: 433-436.
^ McGavin, MD., Zachary, JF. Pathologic Basis of Veterinary Disease, Fourth Edition, Mosby, 2007, pp. 680-686.

Gennari, F. John (2005). Acid-base disorders and their treatment. Informa Health Care. p. 217. ISBN 0-8247-5915-X. {{cite book}}: Cite has empty unknown parameter: |coauthors= (help)

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[1] Taton DF, Hamar D, Lewis LD. Evaluation of ammonium chloride as a urinary acidifier in the cat. Journal of the American Veterinary Medical Association 1984; 184: 433-436.

[2] McGavin, MD., Zachary, JF. Pathologic Basis of Veterinary Disease, Fourth Edition, Mosby, 2007, pp. 680-686.

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Revision as of 23:47, 29 October 2012 edit 129.78.32.22 (talk) No edit summary ← Previous edit		Revision as of 05:37, 6 November 2012 edit undo Thal1989 (talk \| contribs) 34 edits sentence did not make sense, HCl secretion does not directly cause the alkaline tide. Next edit →
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	'''Alkaline tide''' refers to a condition, normally encountered after eating a meal, ~~when~~ [[stomach ~~acid]]~~ is ~~released~~ into the ~~stomach~~ causing a temporary increase in [[pH]] ~~of the blood~~.		'''Alkaline tide''' refers to a condition, normally encountered after eating a meal, where during the production of HCl by parietal cells in the stomach leads the parietal cells also secreting bicarbonate ions across their basolateral membrane and into the interstitial fluid causing a temporary increase in [[pH]].

	During hydrochloric acid secretion in the stomach, the gastric [[parietal cell]]s extract chloride anions, carbon dioxide, water and sodium cations from the blood plasma and in turn release bicarbonate back into the plasma after the hydrochloric acid is formed from carbon dioxide and water constituents. This is to maintain the plasma's electrical balance, as the chloride anions have been extracted. The bicarbonate content causes the venous blood leaving the stomach to be more alkaline than the arterial blood delivered to it.		During hydrochloric acid secretion in the stomach, the gastric [[parietal cell]]s extract chloride anions, carbon dioxide, water and sodium cations from the blood plasma and in turn release bicarbonate back into the plasma after the hydrochloric acid is formed from carbon dioxide and water constituents. This is to maintain the plasma's electrical balance, as the chloride anions have been extracted. The bicarbonate content causes the venous blood leaving the stomach to be more alkaline than the arterial blood delivered to it.