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'''WAP four-disulfide core domain protein 2''' is a [[protein]] that in humans is encoded by the ''WFDC2'' [[gene]].<ref name="pmid1686187">{{cite journal | author = Kirchhoff C, Habben I, Ivell R, Krull N | title = A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors | journal = Biol Reprod | volume = 45 | issue = 2 | pages = 350–7 | year = 1992 | month = Mar | pmid = 1686187 | pmc = | doi =10.1095/biolreprod45.2.350 }}</ref><ref name="pmid10570965">{{cite journal | author = Schummer M, Ng WV, Bumgarner RE, Nelson PS, Schummer B, Bednarski DW, Hassell L, Baldwin RL, Karlan BY, Hood L | title = Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas | journal = Gene | volume = 238 | issue = 2 | pages = 375–85 | year = 1999 | month = Dec | pmid = 10570965 | pmc = | doi =10.1016/S0378-1119(99)00342-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WFDC2 WAP four-disulfide core domain 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10406| accessdate = }}</ref> |
'''WAP four-disulfide core domain protein 2''' - also known as '''Human Epididymis Protein 4'''<ref name='HE4-tumour-marker'> {{cite journal | title = The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma | journal = Cancer Research | date = 2003-07-01 | first = Ingegerd | last = Hellström | coauthors = John Raycraft, Martha Hayden-Ledbetter, Jeffrey A. Ledbetter, Michèl Schummer, Martin McIntosh, Charles Drescher, Nicole Urban, and Karl Erik Hellström | volume = 63 | issue = 13 | pages = 3695-3700 | id = PMID 12839961 | url = http://cancerres.aacrjournals.org/content/63/13/3695.full | accessdate = 2012-11-28}}</ref> (HE4) - is a [[protein]] that in humans is encoded by the ''WFDC2'' [[gene]].<ref name="pmid1686187">{{cite journal | author = Kirchhoff C, Habben I, Ivell R, Krull N | title = A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors | journal = Biol Reprod | volume = 45 | issue = 2 | pages = 350–7 | year = 1992 | month = Mar | pmid = 1686187 | pmc = | doi =10.1095/biolreprod45.2.350 }}</ref><ref name="pmid10570965">{{cite journal | author = Schummer M, Ng WV, Bumgarner RE, Nelson PS, Schummer B, Bednarski DW, Hassell L, Baldwin RL, Karlan BY, Hood L | title = Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas | journal = Gene | volume = 238 | issue = 2 | pages = 375–85 | year = 1999 | month = Dec | pmid = 10570965 | pmc = | doi =10.1016/S0378-1119(99)00342-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WFDC2 WAP four-disulfide core domain 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10406| accessdate = }}</ref> |
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==Usage as a Tumour Marker== |
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HE4 is used as a tumour marker for [[ovarian cancer]]<ref name='HE4-tumour-marker' />. |
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Revision as of 22:46, 28 November 2012
Template:PBB WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4[1] (HE4) - is a protein that in humans is encoded by the WFDC2 gene.[2][3][4]
Usage as a Tumour Marker
HE4 is used as a tumour marker for ovarian cancer[1].
References
- ^ a b Hellström, Ingegerd (2003-07-01). "The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma". Cancer Research. 63 (13): 3695–3700. PMID 12839961. Retrieved 2012-11-28.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Kirchhoff C, Habben I, Ivell R, Krull N (1992). "A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors". Biol Reprod. 45 (2): 350–7. doi:10.1095/biolreprod45.2.350. PMID 1686187.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Schummer M, Ng WV, Bumgarner RE, Nelson PS, Schummer B, Bednarski DW, Hassell L, Baldwin RL, Karlan BY, Hood L (1999). "Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas". Gene. 238 (2): 375–85. doi:10.1016/S0378-1119(99)00342-X. PMID 10570965.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: WFDC2 WAP four-disulfide core domain 2".
Further reading
 | This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it. |