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Kinesin-like protein KIF11: Difference between revisions

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This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008].<ref name="entrez">{{cite web | title = Entrez Gene: Kinesin family member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=3832| accessdate = 2012-01-27T16:36:59.375-08:00}}</ref>
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008].<ref name="entrez">{{cite web | title = Entrez Gene: Kinesin family member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=3832| accessdate = 2012-01-27T16:36:59.375-08:00}}</ref>

==Function in neurons==
KIF11 (also known as kinesin-5 and Eg5) is a homotetramer which cross-links anti-parallel [[microtubules]] in the [[mitotic spindle]] to maintain spindle bipolarity <ref>{{cite journal|pmid=8548803}}</ref> <ref>{{cite journal|pmid=8538794}}</ref> <ref>{{cite journal|pmid=9885249}}</ref> <ref>{{cite journal|pmid=10559864}}</ref>. KIF11 is expressed in all cells during mitosis and in postmitotic neurons during development. In neurons pharmacological inhibition and siRNA knockdown of KIF11 results in longer axons, more branches, fewer bouts of axon retraction and the inability of [[growth cone]]s to turn on contact with repulsive substrates <ref>{{cite journal|pmid=17846176}}</ref> <ref>{{cite journal|pmid=19084405}}</ref> <ref>{{cite journal|pmid=22539840}}</ref>. KIF11, like [[KIF15]] and [[KIF23]], is thought to act as a restrictor of short microtubules moving bi-directionally along the axon, exerting forces antagonistically to cytoplasmic [[dynein]]<ref>{{cite journal|pmid=21048148}}</ref> <ref>{{cite journal|pmid=23035110}}</ref>


==References==
==References==

Revision as of 16:17, 31 December 2012

Template:PBB Kinesin family member 11 is a protein that in humans is encoded by the KIF11 gene.[1]

This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008].[1]

Function in neurons

KIF11 (also known as kinesin-5 and Eg5) is a homotetramer which cross-links anti-parallel microtubules in the mitotic spindle to maintain spindle bipolarity [2] [3] [4] [5]. KIF11 is expressed in all cells during mitosis and in postmitotic neurons during development. In neurons pharmacological inhibition and siRNA knockdown of KIF11 results in longer axons, more branches, fewer bouts of axon retraction and the inability of growth cones to turn on contact with repulsive substrates [6] [7] [8]. KIF11, like KIF15 and KIF23, is thought to act as a restrictor of short microtubules moving bi-directionally along the axon, exerting forces antagonistically to cytoplasmic dynein[9] [10]

References

  1. ^ a b "Entrez Gene: Kinesin family member 11". Retrieved 2012-01-27T16:36:59.375-08:00. {{cite web}}: Check date values in: |accessdate= (help)
  2. ^ . PMID 8548803. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  3. ^ . PMID 8538794. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  4. ^ . PMID 9885249. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  5. ^ . PMID 10559864. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  6. ^ . PMID 17846176. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  7. ^ . PMID 19084405. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  8. ^ . PMID 22539840. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  9. ^ . PMID 21048148. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  10. ^ . PMID 23035110. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

Further reading

  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11328809, please use {{cite journal}} with |pmid=11328809 instead.
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  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 14527417, please use {{cite journal}} with |pmid=14527417 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 14718566, please use {{cite journal}} with |pmid=14718566 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15024728, please use {{cite journal}} with |pmid=15024728 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 1505978, please use {{cite journal}} with |pmid=1505978 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15247293, please use {{cite journal}} with |pmid=15247293 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15665380, please use {{cite journal}} with |pmid=15665380 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15858821, please use {{cite journal}} with |pmid=15858821 instead.
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