1,8-Cineole 2-exo-monooxygenase: Difference between revisions

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1,8-Cineole 2-exo-monooxygenase (EC 1.14.13.157, CYP3A4) is an enzyme with system name 1,8-cineole,NADPH:oxygen oxidoreductase (2-exo-hydroxylating).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

1,8-cineole + NADPH + H⁺ + O₂

\rightleftharpoons

2-exo-hydroxy-1,8-cineole + NADP⁺ + H₂O

1,8-Cineole 2-exo-monooxygenase is a heme-thiolate protein (P-450).

^ Miyazawa, M., Shindo, M. and Shimada, T. (2001). "Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from Eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes". Drug Metab. Dispos. 29: 200–205. PMID 11159812.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Miyazawa, M. and Shindo, M. (2001). "Biotransformation of 1,8-cineole by human liver microsomes". Nat. Prod. Lett. 15: 49–53. PMID 11547423.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Miyazawa, M., Shindo, M. and Shimada, T. (2001). "Roles of cytochrome P₄₅₀ 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes". Xenobiotica. 31: 713–723. PMID 11695850.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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	[[Category:EC 1.14.13]]		[[Category:EC 1.14.13]]

			[[sr:1,8-cineol 2-ekso-monooksigenaza]]