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Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems.^[1]

MPV is higher when there is destruction to platelets. This may be seen as in immune thrombocytopenic purpura (ITP), and in myeloproliferative diseases and Bernard-Soulier syndrome. It may also be related to pre-eclampsia, and recovery from transient hypoplasia.^[2]

Abnormally low MPV values correlate primarily with thrombocytopenia when it is due to impaired production as in aplastic anemia. You may want to research megakaryocyte if you are looking into causes and related information for a low MPV.

A typical range of platelet volumes is 9.7–12.8 fL (femtolitre), equivalent to spheres 2.65 to 2.9 µm in diameter. Normal range is given as 7.5-11.5 fL.

External links

MPV Definition
[3] Medicinenet.com: Thrombocytopenia
[4] Diabetesexplained.com: MPV
[5] ahajournals.org: Article related to MPV
[6]: NIH.gov: article related to MPV
[7] Wisegeekcom: What is Mean Platelet Volume
[8] Clinlabnavigator.com: MPV

^ [1], Lab Tests Online.
^ [2], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..

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[LabTestsOnline-1] [1], Lab Tests Online.

[Arch_Pathol_Lab_Med._Vol_133,_September_2009;1441-43.-2] [2], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..

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 {{Refimprove|date=December 2009}}
-'''Mean platelet volume''' ('''MPV''') is a machine-calculated measurement of the average size of [[platelets]] found in [[blood]] and is typically included in [[blood tests]] as part of the [[Complete blood count|CBC]]. Since the average platelet size is larger when the body is producing increased numbers of platelets the MPV test re can be used to make inferences about platelet production in [[bone marrow]] or platelet destruction problems.<ref name="LabTestsOnline">[http://www.labtestsonline.org/understanding/analytes/cbc/test.html], Lab Tests Online.</ref>
+'''Mean platelet volume''' ('''MPV''') is a machine-calculated measurement of the average size of [[platelets]] found in [[blood]] and is typically included in [[blood tests]] as part of the [[Complete blood count|CBC]]. Since the average platelet size is larger when the body is producing increased numbers of platelets the MPV test results can be used to make inferences about platelet production in [[bone marrow]] or platelet destruction problems.<ref name="LabTestsOnline">[http://www.labtestsonline.org/understanding/analytes/cbc/test.html], Lab Tests Online.</ref>
 MPV is higher when there is destruction to platelets. This may be seen as in [[immune thrombocytopenic purpura]] (ITP), and in [[myeloproliferative disease]]s and [[Bernard-Soulier syndrome]]. It may also be related to [[pre-eclampsia]], and recovery from transient [[hypoplasia]].<ref name="Arch Pathol Lab Med. Vol 133, September 2009;1441-43.">[http://docs.google.com/viewer?a=v&q=cache:WD-fbfqdadUJ:www.metromedlab.com/SiteContent/Documents/File/IPN%2520MPV%2520%2520101609.pdf+%22mean+platelet+volume%22&hl=en&gl=us&pid=bl&srcid=ADGEESjXgOqNk6-jITg3Rn_c64mK0iSxOTrt5I6VycZ4yzlEf3z1ycjsY_1nU1H8hiYmppb3QKniYikKEIXM0CDCnwSvavxsO9wmKvgM2778hWm2McGaIv0Dz0GJzND39M3h3G29wxdw&sig=AHIEtbSsN2L1cvMZLM4tJ5snc9_uaKIADQ&pli=1], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..</ref>

v t e Hematology blood tests
Complete blood count	Hemoglobin Hematocrit Red blood cell count Red blood cell indices Mean corpuscular hemoglobin Mean corpuscular hemoglobin concentration Mean corpuscular volume Red blood cell distribution width White blood cell count White blood cell differential Absolute neutrophil count Platelet count Mean platelet volume Reticulocyte count Reticulocyte index
Other tests of red blood cells	Blood volume Total blood volume (TBV) Plasma volume (PV) Red cell volume (RCV) Fetal hemoglobin Apt–Downey test Kleihauer–Betke test Hemoglobinopathy testing Hemoglobin electrophoresis Sickle solubility test Mentzer index Erythrocyte sedimentation rate Haptoglobin Monocyte distribution width (MDW) Osmotic fragility
Coagulation	Clotting factors Prothrombin time Partial thromboplastin time Thrombin time Activated clotting time Fibrinogen Bleeding time animal enzyme Reptilase time Ecarin clotting time Dilute Russell's viper venom time Thrombin generation assay Calibrated automated thrombogram ST Genesia-based test Thromboelastography Thrombodynamics test Overall hemostatic potential Coagulation activation markers Prothrombin fragments 1+2 Thrombin–antithrombin complex Fibrinopeptide A Fibrin monomers Activated protein C–protein C inhibitor Fibrinolysis Euglobulin lysis time D-Dimer Plasmin-α₂-antiplasmin complex Von Willebrand factor Ristocetin-induced platelet aggregation Activated protein C resistance test aPTT-based activated protein C resistance test ETP-based activated protein C resistance test
Other	Blood film Blood viscosity Nitro blue tetrazolium chloride test Flow cytometry Immunophenotyping