Dense granule: Difference between revisions
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==In multicellular organisms== |
==In multicellular organisms== |
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===Components=== |
===Components=== |
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The dense granules of human [[platelet]]s contain [[adenosine diphosphate]] (ADP), [[adenosine triphosphate]] (ATP), ionized [[calcium]] (which is necessary for several steps of the [[coagulation cascade]]), [[ |
The dense granules of human [[platelet]]s contain [[adenosine diphosphate]] (ADP), [[adenosine triphosphate]] (ATP), ionized [[calcium]] (which is necessary for several steps of the [[coagulation cascade]]), [[histamine]] and [[serotonin]].<ref name="OrkinNathan2009">{{cite book|author1=Stuart H. Orkin|author2=David G. Nathan|author3=David Ginsburg|coauthors=A. Thomas Look|title=Nathan and Oski's hematology of infancy and childhood|url=http://books.google.com/books?id=_9CmOIvgJm4C&pg=PA1386|accessdate=2 November 2010|year=2009|publisher=Elsevier Health Sciences|isbn=978-1-4160-3430-8|pages=1386–}}</ref> |
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===Clinical significance=== |
===Clinical significance=== |
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Revision as of 21:48, 9 February 2013
| Dense granule | |
|---|---|
| Details | |
| Identifiers | |
| Latin | granulum delta |
| TH | H2.00.04.1.03006 |
| Anatomical terminology | |
Dense granules (also known as dense bodies or delta granules) are specialized secretory organelles.
In unicellular organisms
They are found in animals and in unicellular organisms including Apicomplexa protozoans.
They are also found in Entamoeba.[1]
In multicellular organisms
Components
The dense granules of human platelets contain adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium (which is necessary for several steps of the coagulation cascade), histamine and serotonin.[2]
Clinical significance
A deficiency of CD63 can be associated with Hermansky-Pudlak syndrome.[3]
See also
References
- ^ James Joseph Marr; Timothy W. Nilsen; Richard Komuniecki (2003). Molecular medical parasitology. Academic Press. pp. 254–. ISBN 978-0-12-473346-6. Retrieved 12 November 2010.
- ^ Stuart H. Orkin; David G. Nathan; David Ginsburg (2009). Nathan and Oski's hematology of infancy and childhood. Elsevier Health Sciences. pp. 1386–. ISBN 978-1-4160-3430-8. Retrieved 2 November 2010.
{{cite book}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Nishibori M, Cham B, McNicol A, Shalev A, Jain N, Gerrard J (1993). "The protein [[CD63]] is in platelet dense granules, is deficient in a patient with [[Hermansky-Pudlak syndrome]], and appears identical to [[granulophysin]]". J Clin Invest. 91 (4): 1775–82. doi:10.1172/JCI116388. PMC 288158. PMID 7682577.
{{cite journal}}: URL–wikilink conflict (help)CS1 maint: multiple names: authors list (link)
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