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On July 13, 2011, [[Cornell University]] announced it granted ChromaDex exclusive worldwide rights to a novel manufacturing process for nicotinamide riboside (NR).<ref name="S&P"/> NR, a vitamin found in milk, is a more potent version of [[niacin]] (vitamin B3). Like niacin, NR is a precursor to [[nicotinamide adenine dinucleotide]] (NAD), which is elevated by a calorie restricted diet. Increasing cellular NAD has demonstrated cell-protective and positive metabolic effects. In laboratory tests, "NR has shown promise for improving [[cardiovascular]] health, [[glucose]] levels and cognitive function and has demonstrated evidence of anti-ageing effects."<ref name="NO">{{cite web |url= http://www.lef.org/newsletter/2007/2007_05_04.htm |title= Got nicotinamide riboside? |accessdate=2012-05-29 |last=|first= |coauthors= |date=2007-05-04 |work= |publisher=Life Extension |pages= |quote= }}</ref><ref name=Belenky>{{Cite journal| author = Belenky P | coauthors = Bogan KL, Brenner C | title = NAD+ metabolism in health and disease | journal = Trends Biochem. Sci. | volume = 32 | issue = 1 | pages = 12–9 | year = 2007 | pmid = 17161604 | url = http://biochem.uiowa.edu/brenner/documents/belenky07a.pdf | accessdate = 2007-12-23 | doi = 10.1016/j.tibs.2006.11.006|format=PDF}}</ref>
On July 13, 2011, [[Cornell University]] announced it granted ChromaDex exclusive worldwide rights to a novel manufacturing process for nicotinamide riboside (NR).<ref name="S&P"/> NR, a vitamin found in milk, is a more potent version of [[niacin]] (vitamin B3). Like niacin, NR is a precursor to [[nicotinamide adenine dinucleotide]] (NAD), which is elevated by a calorie restricted diet. Increasing cellular NAD has demonstrated cell-protective and positive metabolic effects. In laboratory tests, "NR has shown promise for improving [[cardiovascular]] health, [[glucose]] levels and cognitive function and has demonstrated evidence of anti-ageing effects."<ref name="NO">{{cite web |url= http://www.lef.org/newsletter/2007/2007_05_04.htm |title= Got nicotinamide riboside? |accessdate=2012-05-29 |last=|first= |coauthors= |date=2007-05-04 |work= |publisher=Life Extension |pages= |quote= }}</ref><ref name=Belenky>{{Cite journal| author = Belenky P | coauthors = Bogan KL, Brenner C | title = NAD+ metabolism in health and disease | journal = Trends Biochem. Sci. | volume = 32 | issue = 1 | pages = 12–9 | year = 2007 | pmid = 17161604 | url = http://biochem.uiowa.edu/brenner/documents/belenky07a.pdf | accessdate = 2007-12-23 | doi = 10.1016/j.tibs.2006.11.006|format=PDF}}</ref>

A serious, and likely fatal blow, was struck against the potential utilization of NR as either a pharmaceutical or dietary supplement, with the release today of the results of a study done by Merck Pharmaceuticals. In this very large scale human clinical trial it was found that Niacin no only did not reduce heart attacks, strokes, deaths, or heart procedures, but, even more worryingly, there was also a “serious adverse event” that occurred more frequently among those who took the medicine than among those who didn’t, and the study showed unexpectedly higher levels of bleeding and infections in the group taking the drug versus the placebo. NR, as stated in this article, is a form of Niacin thought to be even more potent than Niacin itself.


==Contract research services & capabilities==
==Contract research services & capabilities==

Revision as of 16:58, 16 March 2013

ChromaDex
Company typePublic
CDXC.OB
IndustryPharmaceuticals, Natural products
Founded1999
HeadquartersIrvine, California, United States
Key people
Frank Jaksch
(Co-Founder, CSO)
ProductspTeroPure
WebsiteChromaDex.com

ChromaDex is a publicly traded natural products company based in Irvine, California. The company is most well known for its industry standard phytochemical testing laboratories and catalogue. In cooperation with the University of Mississippi, the company is currently exploring the effects of pterostiibene on humans.[1][2]

ChromaDex has licensed patents from the University of Mississippi and the USDA to commercially develop pterostilbene and sell the compound trademarked as pTeroPure via the company's BluScience product line.[1][3]

In 2010, ChromaDex won the North American Frost & Sullivan Award for Most Promising Ingredient of the Year for pTeroPure pterostilbene.[1][4]

American billionaire and pharmaceutical entrepreneur Phillip Frost owns approximately 19% of ChromaDex.[1][5][6]

Early history

ChromaDex was founded in 1999. According to a Standard & Poor's research report, the company was created "in response to growing demand for natural product reference standards, materials and services. It has worked to establish itself as an industry leader in nutraceutical and botanical certification, and even publishes its own manual outlining specifications for phytochemicals." On July 14, 2008 ChromaDex merged with CDI Acquisition, a subsidiary of Cody Resources Inc. On July 29, 2008 the company completed a private placement agreement, which yielded gross proceeds of $4.67 million.[1][7]

Later in 2008, ChromaDex (OTCBB: CDXC) became a publicly traded company. Shares of ChromaDex are traded on the NASD Over-The-Counter Bulletin Board.[1] As of April 2012, there were 90.1 million shares outstanding.[8]

ChromaDex catalogue

The ChromaDex catalogue "provides phytochemical reference standards, botanical reference materials and research grade materials for the natural products industry." The company sells over 3,000 phytochemicals and 470 botanical reference materials in its catalogue. The company's products reach a wide range of markets including food & beverage, pharmaceutical, cosmeceutical, research organizations and governmental groups.[1]

BluScience and pTeroPure

ChromaDex received exclusive worldwide patent rights for its pTeroPure pterostilbene product based on the technology licensed from the University of Mississippi and the USDA.[1] Similar to resveratrol, which the Mayo Clinic describes as "a key ingredient in red wine that helps prevent damage to blood vessels, reduces "bad" cholesterol and prevents blood clots"[1][9] pterostilbene belongs to a class of compounds called phytoalexins, which are antimicrobial substances synthesized de novo by plants that accumulate rapidly at areas of incompatible pathogen infection. Based on animal studies pterostilbene is thought to exhibit anti-cancer, anti-hypercholesterolemia, anti-hypertriglyceridemia properties, as well as fight off and reverse cognitive decline.[1][10]

Pterostilbene and resveratrol have similar pharmacologic properties. However pterostilbene has exhibited advantages over resveratrol including superior biological activity, better oral bioavailability, and a slower metabolizing time, which provides more time for the compound's antioxidant activities to act.[1][11][12][13]

According to the USDA, "pterostilbene is one of many aromatic hydrocarbons called stilbenes." ChromaDex's pTeroPure is an identical form of trans-pterostilbene. The company sells pTeroPure under its BluScience product line.[1][14]

The University of California, Irvine, is currently studying pTeroPure for its efficacy as a treatment for melanomas and other skin cancers when used in a skincare product.[15]

Nicotinamide riboside technology

On July 13, 2011, Cornell University announced it granted ChromaDex exclusive worldwide rights to a novel manufacturing process for nicotinamide riboside (NR).[1] NR, a vitamin found in milk, is a more potent version of niacin (vitamin B3). Like niacin, NR is a precursor to nicotinamide adenine dinucleotide (NAD), which is elevated by a calorie restricted diet. Increasing cellular NAD has demonstrated cell-protective and positive metabolic effects. In laboratory tests, "NR has shown promise for improving cardiovascular health, glucose levels and cognitive function and has demonstrated evidence of anti-ageing effects."[15][16]

Contract research services & capabilities

ChromaDex also offers contract research services that help customers source raw materials, identify new compounds and develop processes for large scale manufacturing. The company also has a number of analytical capabilities including gas chromatography, mass spectrometry, and high performance liquid chromatography.[1][8]

See also

Phillip Frost
Pterostilbene
Resveratrol

References

  1. ^ a b c d e f g h i j k l m n Standard & Poor's (2012). "ChromaDex: Standard & Poor's Factual Report". Standard & Poors. p. 11. Retrieved 2012-05-20. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
  2. ^ http://clinicaltrials.gov/ct2/show/NCT01267227 Effect of Pterostilbene on Cholesterol, Blood Pressure and Oxidative Stress
  3. ^ Neeb, Matthew (6-20-2011). "Ole Miss grants exclusive patent rights to ChromaDex Corp". The Daily Mississippian. Retrieved 2012-05-25. {{cite web}}: Check date values in: |date= (help); Cite has empty unknown parameter: |coauthors= (help)
  4. ^ "Frost & Sullivan Recognizes ChromaDex for the Unique Potential Its Commercially Available Product Offers in the Human Nutrition Industry". Yahoo Finance. 5-3-2011. Retrieved 2012-05-25. {{cite web}}: Check date values in: |date= (help); Cite has empty unknown parameter: |coauthors= (help)
  5. ^ Gould, David (5-3-2011). "Billionaire Phillip Frost: A Case Study In Synergy". TREFIS. Retrieved 2012-05-29. {{cite web}}: Check date values in: |date= (help); Cite has empty unknown parameter: |coauthors= (help)
  6. ^ "ChromaDex Corp. Names Consumer Products Veteran Jeffrey Himmel CEO". 1-23-2012. Retrieved 2012-05-29. {{cite web}}: Check date values in: |date= (help); Cite has empty unknown parameter: |coauthors= (help)
  7. ^ "Functional Ingredients". 5-10-2009. Retrieved 2012-05-29. {{cite web}}: Check date values in: |date= (help); Cite has empty unknown parameter: |coauthors= (help)
  8. ^ a b "ChromaDex Red Chip Small Cap Investor Conference Presentation". 4-26-2011. Retrieved 2012-05-29. {{cite web}}: Check date values in: |date= (help); Cite has empty unknown parameter: |coauthors= (help)
  9. ^ Mayo Clinic Staff (3-4-2011). "Red wine and resveratrol: Good for your heart?". Mayo Clinic. Retrieved 2012-05-29. {{cite web}}: Check date values in: |date= (help); Cite has empty unknown parameter: |coauthors= (help)
  10. ^ Braslavsky, Andrea, "Blueberries May Be King of the Hill for Those Over the Hill," WebMD Medical News, Sept. 16, 1999, retrieved December 29, 2006.
  11. ^ IM Kapetanovic; et al. (2010). "Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats". Cancer Chemother Pharmacol. 68 (3): 593–601. doi:10.1007/s00280-010-1525-4. PMC 3090701. PMID 21116625. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)
  12. ^ CM Remsberg; et al. (2008). "Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity". Phytother Res. 22 (2): 169–79. doi:10.1002/ptr.2277. PMID 17726731. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)
  13. ^ P Ferrer; et al. (2005). "Association between Pterostilbene and Quercetin Inhibits Metastatic Activity of B16 Melanoma". Neoplasia. 7 (1): 37–47. doi:10.1593/neo.04337. PMC 1490314. PMID 15736313. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)
  14. ^ Pons, Luis. "Pterostilbene's Healthy Potential". USDA. Retrieved 2012-05-29. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
  15. ^ a b "Best of 2011 Ingredient Supplier: ChromaDex". Nutritional Outlook. Retrieved 2012-05-29. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help) Cite error: The named reference "NO" was defined multiple times with different content (see the help page).
  16. ^ Belenky P (2007). "NAD+ metabolism in health and disease" (PDF). Trends Biochem. Sci. 32 (1): 12–9. doi:10.1016/j.tibs.2006.11.006. PMID 17161604. Retrieved 2007-12-23. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
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