Molybdopterin synthase: Difference between revisions
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{{Infobox enzyme |
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| Name = Molybdopterin synthase |
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from precursor Z (now known as [[cyclic pyranopterin monophosphate]]). |
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| EC_number = 2.8.1.12 |
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| CAS_number = |
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| IUBMB_EC_number = 2/8/1/12 |
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| GO_code = |
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from precursor Z (now known as [[cyclic pyranopterin monophosphate]]).<ref>{{cite journal | title = Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency |author = Daniels, J.N., Wuebbens, M.M., Rajagopalan, K.V. and Schindelin, H. |journal = Biochemistry |date = 2008 |volume = 47 |pages = 615-626 |pmid = 18092812}}</ref><ref>{{cite journal | title = Mechanistic and mutational studies of <em>Escherichia coli</em> molybdopterin synthase clarify the final step of molybdopterin biosynthesis |author = Wuebbens, M.M. and Rajagopalan, K.V. |journal = J. Biol. Chem. |date = 2003 |volume = 278 |pages = 14523-14532 |pmid = 12571226}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]] |
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: cyclic pyranopterin monophosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH<sub>2</sub>-C(O)SH + H<sub>2</sub>O <math>\rightleftharpoons</math> [[molybdopterin]] + 2 molybdopterin-synthase sulfur-carrier protein |
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It is [[heterodimeric]] and coded for by the [[MOCS2]] gene.<ref>{{cite journal | last1=Sloan | first1=J | last2=Kinghorn | first2=JR | last3=Unkles | first3=SE | title=The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames | journal=Nucleic Acids Research | volume=27 | issue=3 | pages=854–8 | year=1999 | pmc=148257| pmid =9889283 | doi=10.1093/nar/27.3.854}}</ref> |
It is [[heterodimeric]] and coded for by the [[MOCS2]] gene.<ref>{{cite journal | last1=Sloan | first1=J | last2=Kinghorn | first2=JR | last3=Unkles | first3=SE | title=The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames | journal=Nucleic Acids Research | volume=27 | issue=3 | pages=854–8 | year=1999 | pmc=148257| pmid =9889283 | doi=10.1093/nar/27.3.854}}</ref> |
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Revision as of 07:08, 30 March 2013
| Molybdopterin synthase | |||||||||
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| Identifiers | |||||||||
| EC no. | 2.8.1.12 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Molybdopterin synthase (EC 2.8.1.12, MPT synthase) is an enzyme required to sythesize molybdenum cofactor (MoCo) from precursor Z (now known as cyclic pyranopterin monophosphate).[1][2] This enzyme catalyses the following chemical reaction
- cyclic pyranopterin monophosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + H2O molybdopterin + 2 molybdopterin-synthase sulfur-carrier protein
It is heterodimeric and coded for by the MOCS2 gene.[3]
References
- ^ Daniels, J.N., Wuebbens, M.M., Rajagopalan, K.V. and Schindelin, H. (2008). "Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency". Biochemistry. 47: 615–626. PMID 18092812.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Wuebbens, M.M. and Rajagopalan, K.V. (2003). "Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis". J. Biol. Chem. 278: 14523–14532. PMID 12571226.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Sloan, J; Kinghorn, JR; Unkles, SE (1999). "The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames". Nucleic Acids Research. 27 (3): 854–8. doi:10.1093/nar/27.3.854. PMC 148257. PMID 9889283.
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