Fructuronate reductase

fructuronate reductase
Identifiers
EC no.	1.1.1.57
CAS no.	9028-44-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a fructuronate reductase (EC 1.1.1.57) is an enzyme that catalyzes the chemical reaction

D-mannonate + NAD⁺ $\rightleftharpoons$ D-fructuronate + NADH + H⁺

Thus, the two substrates of this enzyme are D-mannonate and NAD⁺, whereas its 3 products are D-fructuronate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-mannonate:NAD⁺ 5-oxidoreductase. Other names in common use include mannonate oxidoreductase, mannonic dehydrogenase, D-mannonate dehydrogenase, and D-mannonate:NAD⁺ oxidoreductase. This enzyme participates in pentose and glucuronate interconversions.

References

• Hickman J and Ashwell G (1960). "Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehyrogenases in Escherichia coli". J. Biol. Chem. 235: 1566–1570.
• Kilgore WW, Starr MP (1959). "Catabolism of galacturonic and glucuronic acids by Erwinia carotovora". J. Biol. Chem. 234: 2227–35. PMID 14409051.