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'''Robert S. Coleman''' was a faculty member at both [[Ohio State University]] and the [[University of South Carolina]]. At Ohio State, he was on the faculty in the Department of Chemistry from 1996-2012, having moved to Ohio State as an Associate Professor from the [[University of South Carolina]]. At USC, Coleman taught as Assistant Professor from 1989 to 1995, and then as Associate Professor (with tenure) from 1995 to 1996. In 1996, he accepted a faculty position at Ohio to teach Organic Chemistry, where he was an Associate Professor from 1996 until 2000. He was promoted to Full Professor in 2000, teaching Organic Chemistry up until his retirement in 2012. Professor Coleman is nationally and internationally recognized as a leading practitioner in the field of [[organic synthesis|synthetic organic]] and [[medicinal chemistry]], and as a collaborator in a number of multidisciplinary research programs. He received his Ph.D. degree working with Professor [[Dale L. Boger]] (then at Purdue), completing the first total synthesis of the antitumor agent [[CC-1065]].<ref>''J. Am. Chem. Soc.'' 1988, 10, 1321</ref> He was subsequently an NIH postdoctoral fellow at [[Yale University]] with Professor [[Samuel J. Danishefsky]], where he completed (with M. Paz Cabal), the first total synthesis of the aglycone of the antitumor agent [[calicheamicin]].<ref>''J. Am. Chem. Soc.'' '''1990''', ''112'', 3253</ref>
'''Robert S. Coleman''' was a faculty member at both [[Ohio State University]] and the [[University of South Carolina]]. At Ohio State, he was on the faculty in the Department of Chemistry from 1996-2012, having moved to Ohio State as an Associate Professor from the [[University of South Carolina]]. At USC, Coleman taught as Assistant Professor from 1989 to 1995, and then as Associate Professor (with tenure) from 1995 to 1996. In 1996, he accepted a faculty position at Ohio State University to teach Organic Chemistry, where he was an Associate Professor from 1996 until 2000. He was promoted to Full Professor in 2000, teaching Organic Chemistry up until his retirement in 2012. Professor Coleman is nationally and internationally recognized as a leading practitioner in the field of [[organic synthesis|synthetic organic]] and [[medicinal chemistry]], and as a collaborator in a number of multidisciplinary research programs. He received his Ph.D. degree working with Professor [[Dale L. Boger]] (then at Purdue), completing the first total synthesis of the antitumor agent [[CC-1065]].<ref>''J. Am. Chem. Soc.'' 1988, 10, 1321</ref> He was subsequently an NIH postdoctoral fellow at [[Yale University]] with Professor [[Samuel J. Danishefsky]], where he completed (with M. Paz Cabal), the first total synthesis of the aglycone of the antitumor agent [[calicheamicin]].<ref>''J. Am. Chem. Soc.'' '''1990''', ''112'', 3253</ref>




Revision as of 22:50, 30 July 2013

Robert S. Coleman was a faculty member at both Ohio State University and the University of South Carolina. At Ohio State, he was on the faculty in the Department of Chemistry from 1996-2012, having moved to Ohio State as an Associate Professor from the University of South Carolina. At USC, Coleman taught as Assistant Professor from 1989 to 1995, and then as Associate Professor (with tenure) from 1995 to 1996. In 1996, he accepted a faculty position at Ohio State University to teach Organic Chemistry, where he was an Associate Professor from 1996 until 2000. He was promoted to Full Professor in 2000, teaching Organic Chemistry up until his retirement in 2012. Professor Coleman is nationally and internationally recognized as a leading practitioner in the field of synthetic organic and medicinal chemistry, and as a collaborator in a number of multidisciplinary research programs. He received his Ph.D. degree working with Professor Dale L. Boger (then at Purdue), completing the first total synthesis of the antitumor agent CC-1065.[1] He was subsequently an NIH postdoctoral fellow at Yale University with Professor Samuel J. Danishefsky, where he completed (with M. Paz Cabal), the first total synthesis of the aglycone of the antitumor agent calicheamicin.[2]


Research

Coleman's independent research contributions include:

  • Accomplished the first total chemical synthesis of the novel antitumor agent azinomycin A [3]
  • Developed the first synthesis of DNA containing sulfur-bearing nucleosides [4]
  • Developed the first stereocontrolled total synthesis of the kinase inhibitor calphostin A [5]
  • Developed the first computer generated model of an azinomycin B/DNA crosslink [6]
  • Developed the first fluorescent probe for studying ultrafast DNA dynamics [7]
  • Published the first comprehensive study of the DNA binding properties of azinomycin B [8]
  • Developed a novel hetero-bis-metallated butadiene for the synthesis of polyene natural products,[9] including the first total synthesis of the antitumor agent lucilactaene [10] and 2'-O-methylmyxalamide D.[11]

References

  1. ^ J. Am. Chem. Soc. 1988, 10, 1321
  2. ^ J. Am. Chem. Soc. 1990, 112, 3253
  3. ^ Angew. Chem., Int. Ed. 2001, 40, 1736
  4. ^ J. Am. Chem. Soc. 1992, 114, 9229
  5. ^ J. Am. Chem. Soc. 1995, 117, 10889
  6. ^ J. Med. Chem. 2002, 45, 861
  7. ^ J. Org. Chem. 1998, 63, 5700
  8. ^ J. Am. Chem. Soc. 2002, 124, 13008
  9. ^ Org. Lett. 2005, 7, 2289
  10. ^ J. Am. Chem. Soc. 2005, 127, 16038
  11. ^ J. Am. Chem. Soc. 2007, 129, 3826

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