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An add-on program for Windows computers – [http://efmer.eu/boinc/ TThrottle] – can solve the problem of overheating by directly limiting the BOINC project's use of the host computer. It does this by measuring the CPU and/or the GPU temperature and adjusts the run time accordingly. It also uses a shorter switching time of less than one second, resulting in less temperature change during switching.
An add-on program for Windows computers – [http://efmer.eu/boinc/ TThrottle] – can solve the problem of overheating by directly limiting the BOINC project's use of the host computer. It does this by measuring the CPU and/or the GPU temperature and adjusts the run time accordingly. It also uses a shorter switching time of less than one second, resulting in less temperature change during switching.
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==Active projects==
==Active projects==

===FightAIDS@Home===
===FightAIDS@Home===
{{Main|FightAIDS@Home}}
{{Main|FightAIDS@Home}}
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|publisher=World Community Grid
|accessdate=2011-10-28}}</ref>
|accessdate=2011-10-28}}</ref>



===Say No to Schistosoma===
===Say No to Schistosoma===
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|publisher=PLoS Biology
|publisher=PLoS Biology
|accessdate=2007-07-30
|accessdate=2007-07-30
}}</ref>
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===Help Defeat Cancer===
===Help Defeat Cancer===
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|accessdate=2013-05-21
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The project finished on March 2013. The latest update is available [https://secure.worldcommunitygrid.org/forums/wcg/viewthread_thread,34893_offset,0#416153 here]. Chemical compounds have been discovered to inhibit both dengue and West Nile virus proteases. A handful of analogs developed from the initial computer-discovered dengue leads have entered crucial pre-clinical pharmacokinetic and efficacy studies
The project finished on March 2013. The latest update is available [https://secure.worldcommunitygrid.org/forums/wcg/viewthread_thread,34893_offset,0#416153 here]. Chemical compounds have been discovered to inhibit both dengue and West Nile virus proteases. A handful of analogs developed from the initial computer-discovered dengue leads have entered crucial pre-clinical pharmacokinetic and efficacy studies
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In the latest status report, published on November 2012 and available [http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,34265_offset,0#401213 here], the scientists reported that several compounds had been found to inhibit the virus activity. 20 compounds were ordered, 19 actually arrived, of which 3 were not soluble. From the remaining 16, 7 inhibited Mtb InhA(Mycobacterium tuberculosis). The best hit displayed an IC50 value of approximately 40 micro-Molar. The discovery of this compound is important because of the drug resistant superbugs of Mycobacterium tuberculosis.
In the latest status report, published on November 2012 and available [http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,34265_offset,0#401213 here], the scientists reported that several compounds had been found to inhibit the virus activity. 20 compounds were ordered, 19 actually arrived, of which 3 were not soluble. From the remaining 16, 7 inhibited Mtb InhA(Mycobacterium tuberculosis). The best hit displayed an IC50 value of approximately 40 micro-Molar. The discovery of this compound is important because of the drug resistant superbugs of Mycobacterium tuberculosis.


On May 22nd, it was [http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,35038_offset,10#422145 announced] that the project was entering the final stages and should finish soon.
On May 22, it was [http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,35038_offset,10#422145 announced] that the project was entering the final stages and should finish soon.


===Human Proteome Folding – Phase 2===
===Human Proteome Folding – Phase 2===
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==Inactive projects==
==Inactive projects==

===AfricanClimate@Home===
===AfricanClimate@Home===
The mission of AfricanClimate@Home is to develop more accurate climate models of specific regions in Africa. This will serve as a basis for understanding how the climate will change in the future so that measures designed to alleviate the adverse effects of climate change can be implemented. World Community Grid's tremendous computing power will be used to understand and reduce the uncertainty with which climate processes are simulated over Africa. Phase 1 of African Climate@Home launched on September 3, 2007,<ref name="AfricanClimate launch">{{cite web |url=http://www.csag.uct.ac.za/worldcommunitygrid|title=AfricanClimate@Home (IBM World Community Grid) Status Page|publisher=[[University of Cape Town]]|accessdate=2009-05-08}}</ref> and ended in July 2008.<ref name="AfricanClimate SC">{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/ach/viewAchMain.do|title=AfricanClimate@Home|publisher=World Community Grid|accessdate=2009-05-08}}</ref> There are currently no plans for a 2nd phase.
The mission of AfricanClimate@Home is to develop more accurate climate models of specific regions in Africa. This will serve as a basis for understanding how the climate will change in the future so that measures designed to alleviate the adverse effects of climate change can be implemented. World Community Grid's tremendous computing power will be used to understand and reduce the uncertainty with which climate processes are simulated over Africa. Phase 1 of African Climate@Home launched on September 3, 2007,<ref name="AfricanClimate launch">{{cite web |url=http://www.csag.uct.ac.za/worldcommunitygrid|title=AfricanClimate@Home (IBM World Community Grid) Status Page|publisher=[[University of Cape Town]]|accessdate=2009-05-08}}</ref> and ended in July 2008.<ref name="AfricanClimate SC">{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/ach/viewAchMain.do|title=AfricanClimate@Home|publisher=World Community Grid|accessdate=2009-05-08}}</ref> There are currently no plans for a 2nd phase.

Revision as of 05:01, 6 October 2013

World Community Grid
World Community Grid
Developer(s)IBM
Initial releaseNovember 16, 2004 (2004-11-16)[1]
Stable releaseWorld Community Grid: 6.10.58
Development statusActive
Operating systemMicrosoft Windows, Linux, Mac OS X, FreeBSD, Android
PlatformBOINC
TypeVolunteer computing
Average performance450.858 TFLOPS[2]
Active users73,307[2]
Total users407,253[2]
Active hosts217,548[2]
Total hosts1,747,017[2]
Websiteworldcommunitygrid.org

World Community Grid (WCG) is an effort to create the world's largest public computing grid to tackle scientific research projects that benefit humanity.[3] Launched on November 16, 2004, it is funded and operated by IBM with client software currently available for Windows, Linux, Mac OS X, and FreeBSD operating systems.[4][5][6]

Using the idle time of computers around the world, World Community Grid's research projects have analyzed aspects of the human genome, HIV, dengue, muscular dystrophy, cancer, influenza, rice crop yields, and clean energy. The organization has so far partnered with over 400 other companies and organizations to assist in its work and has over 73,000 active registered users as of June 2013.[2][7]

History

IBM and other research participants sponsored the Smallpox Research Grid Project to accelerate the discovery of a cure for smallpox.[8] The smallpox study used a massive distributed computing grid to analyze compounds' effectiveness against smallpox.[9] The project allowed scientists to screen 35 million potential drug molecules against several smallpox proteins to identify good candidates for developing into smallpox treatments. In the first 72 hours, 100,000 results were returned. By the end of the project, 44 strong treatment candidates had been identified.[10] Based on the success of the Smallpox study, IBM announced on November 16, 2004 the creation of World Community Grid with the goal of creating a technical environment where other humanitarian research could be processed.[1][9]

World Community Grid initially only supported Windows, using the proprietary Grid MP software from United Devices which powered the grid.org distributed computing projects. Demand for Linux support led to the addition in November 2005 of open source BOINC grid technology which powers projects such as SETI@home and Climateprediction,[11] and Mac OS X and Linux support was added since the introduction of BOINC.[4] In 2007, the World Community Grid migrated from Grid MP to BOINC for all of its supported platforms.[12]

Scale of the project

As of June 2013, World Community Grid had over 68,000 active user accounts, with over 217,000 active hosting devices.[2] Over the course of the project, over 729,000 cumulative years of computing time have been donated, and over 1 billion workunits have been completed.[7]

Operation

The World Community Grid client software works in the background, showing itself as a small icon in the system tray. When the BOINC client is used, as in this example, the icon is a small "B."
The client software's status window, displaying information about the work currently being done in the background. This particular computer is 60.3% complete with its current workunit. When it reaches 100%, it will start on a new workunit and the results of the previous workunit will be transmitted back to WCG.

The World Community Grid software uses the idle time of Internet-connected computers to perform research calculations.[13] Users install WCG client software onto their computers. This software works in the background, using spare system resources to process work for WCG.[13][14] When a piece of work or workunit is completed, the client software sends it back to WCG over the Internet and downloads a new workunit.[3][15] To ensure accuracy, the WCG servers send out multiple copies of each workunit.[16] Then, when the results are received, they are collected and validated against each other.[17][18] Users may choose to use graphics output by the current workunit as a screensaver.

While many public computing grids such as SETI@home and Folding@home are devoted to a single project, World Community Grid offers multiple humanitarian projects under a single umbrella. Users are included in all projects by default, but may opt out of projects as they choose.[19]

When World Community Grid launched, they used the proprietary Grid MP client from United Devices. After adding support for the open source BOINC client in 2005, World Community Grid eventually discontinued the Grid MP client and consolidated on the BOINC platform in 2008.[20]

Even though WCG makes use of open source client software, the actual applications that perform the scientific calculations may not be. However, several of the science applications are available under a free license, although the source is not available directly from WCG.[21]

Potential problems

The picture shows particular two CPU usage history (under Hyper-threading) when BOINC client software is processing two tasks on each CPU under Microsoft Windows XP SP2. CPU usage history indicates almost 0% to 100% swing with peak to peak of 3 seconds interval, when view +update speed set to high, at first half recording period. The rest of half period of history is set to update speed normal, and upper CPU usage history indicates slightly more than 60% and lower CPU usage history show 35% approx. in average.

Because the World Community Grid software increases CPU usage by consuming unused processing time, it is possible for the software to cause abnormal behavior on volunteered computers. Despite the unobtrusive nature of the software, decreases in system performance could still occur. High CPU usage could also cause a (misconfigured) computer to overheat.

The BOINC client avoids this using a variety of limits that suspend computation when there are insufficient free resources. Unlike other BOINC projects, World Community Grid set the BOINC defaults conservatively, making the chances of computer damage extremely small. The default CPU throttle is 60%. The throttle is coarse-grained; for example, if usage is set to 60% it will work at 100% for 3 seconds, then at 0% for 2 seconds, resulting in an average decrease of processor use.[22]

An add-on program for Windows computers – TThrottle – can solve the problem of overheating by directly limiting the BOINC project's use of the host computer. It does this by measuring the CPU and/or the GPU temperature and adjusts the run time accordingly. It also uses a shorter switching time of less than one second, resulting in less temperature change during switching.

Statistics and competition

The contributions of each user are recorded and user contribution statistics are publicly available.[7] Due to the fact that the processing time of each workunit varies from computer to computer depending on the difficulty of the workunit, the speed of the computer and the amount of idle resources available, contributions are usually measured in terms of points. Points are awarded for each workunit depending on the effort required to process that workunit.[23]

Upon completing a workunit, the BOINC client will request the number of points it thinks it deserves based on software benchmarks (see BOINC Credit System#Cobblestones). Since multiple computers process the same workunit to ensure accuracy, the World Community Grid servers can look at the points claimed by each of those computers. The WCG servers disregard statistical outliers, average the remaining values and award the resulting number of points to each computer.[24][25]

Within the grid, users may join teams that have been created by organizations, groups, or individuals. Teams allow for a heightened sense of community identity and can also inspire competition. As teams compete against each other, more work is done for the grid overall.[26]

Outreach

World Community Grid recognizes companies and organizations as partners if they promote WCG within their company or organization. As of April 11, 2013, WCG had 456 partners.[27]

Also, as part of its commitment to improving human health and welfare, the results of all computations completed on World Community Grid are released into the public domain and made available to the scientific community.[3]

Active projects

FightAIDS@Home

Main article: FightAIDS@Home

FightAIDS@Home (launched November 21, 2005[28]) was World Community Grid's second project and its first to target a single disease. Each individual computer processes one potential drug molecule and tests how well it would dock with HIV protease, acting as a protease inhibitor.[29] Scripps Research Institute published its first peer-reviewed scientific paper about the results of FightAIDS@Home on April 21, 2007.[30] This paper explains that the results up to that point will primarily be used to improve the efficiency of future FightAIDS@Home calculations.[31]

On February 3, 2010, the project announced it found two compounds that make a completely new class of AIDS-fighting drugs possible: "two compounds that act on novel binding sites for an enzyme used by the human immunodeficiency virus (HIV), the virus that causes AIDS. The discovery lays the foundation for the development of a new class of anti-HIV drugs to enhance existing therapies, treat drug-resistant strains of the disease, and slow the evolution of drug resistance in the virus."

The latest progress report (February 2013) can be found here.

In a July 2012 status report, the project scientists reported that the results generated by the WCG calculations are being used by Dr. Markus Landthaler of the Max Delbruch Center for Molecular Medicine (MDC) in Berlin. The HPF2 results helped Dr. Markus Landthaler and his collaborators in writing up a new paper on "The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts" available here. More papers describing the results of the HPF2 project are available at its website.

Help Fight Childhood Cancer

Main article: Help Fight Childhood Cancer

Help Fight Childhood Cancer project (launched March 13, 2009[32]) is sponsored by the scientists at Chiba Cancer Center Research Institute and Chiba University.[33] The mission of the Help Fight Childhood Cancer project is to find drugs that can disable three particular proteins associated with neuroblastoma, one of the most frequently occurring solid tumors in children. Identifying these drugs could potentially make the disease much more curable when combined with chemotherapy treatment.[34]

In the latest status report from March 2013, available here, the scientists report that for T1 protein(the first out of, so far, 10 targets analyzed in the WCG), two kinds of chemical compounds have been found and that these findings have been submitted to the Journal of Cancer Research.

The Clean Energy Project – Phase 2

Main article: Clean Energy Project

The Clean Energy project (launched June 28, 2010[35]) is sponsored by the scientists of Harvard University's Department of Chemistry and Chemical Biology.[36] The mission of the Clean Energy Project is to find new materials for the next generation of solar cells and later, energy storage devices. Researchers are employing molecular mechanics and electronic structure calculations to predict the optical and transport properties of molecules that could become the next generation of solar cell materials. By harnessing the computing power of the World Community Grid, researchers can calculate the electronic properties of tens of thousands of organic materials – many more than could ever be tested in a lab – and determine which candidates are most promising for developing affordable solar energy technology.[37]

Computing for Clean Water

Computing for Clean Water (launched September 20, 2010[38][39]) is sponsored by the Center for Nano and Micro Mechanics of Tsinghua University in Beijing. The project's mission is to provide deeper insight on the molecular scale into the origins of the efficient flow of water through a novel class of filter materials. This insight will in turn guide future development of low-cost and more efficient water filters. It is estimated that 1.2 billion people lack access to safe drinking water, and 2.6 billion have little or no sanitation. As a result, millions of people die annually – an estimated 3,900 children a day due to a lack of clean water.[40]

Say No to Schistosoma

Say No to Schistosoma (launched February 22, 2012[41]) is the 20th research project to be launched on World Community Grid. The researchers at Infórium University in Belo Horizonte and FIOCRUZ-Minas, Brazil, are running this project on World Community Grid to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins. This will help find the most promising compounds that may lead to effective treatments for the disease.[42]

As of February 2013, the scientists report that 18 compounds that inhibit the virus activity are being tested in vitro and in vivo. They also report that an additional 23 compounds are being evaluated to be tested.[43]

In August 2013, it was reported that the project was ready to conduct human testing based on their findings. They will ask for authorization from the Brazilian Research Ethics Committee which should take between 6 to 8 months. [1]

Completed projects

Human Proteome Folding – Phase 1

Main article: Human Proteome Folding Project

The first project launched on World Community Grid was the Human Proteome Folding Project, or HPF1, which aims to predict the structure of human proteins. The project was launched on November 16, 2004,[44] and completed on July 18, 2006.[44] This project was unique in that computation was done in tandem with the grid.org distributed computing project.[45] Devised by Richard Bonneau at the Institute for Systems Biology, the project used grid computing to produce the likely structures for each of the proteins using a Rosetta Score. From these predictions, researchers hope to predict the function of the myriad proteins. This increased understanding of the human proteins could prove vital in the search for cures to human diseases.[46] Computing for this project was officially completed on July 18, 2006.[47] Research results for the yeast portion of HPF1 have been published.[48]

Help Defeat Cancer

Main article: Help Defeat Cancer

The Help Defeat Cancer project seeks to improve the ability of medical professionals to determine the best treatment options for patients with breast, head, or neck cancer. The project was launched on July 20, 2006,[44] and completed on April 2007.[44] The project worked by identifying visual patterns in large numbers of tissue microarrays taken from archived tissue samples. By correlating the pattern data with information about treatment and patient outcome, the results of this project could help provide better targeted treatment options.[49]

Genome Comparison

Main article: Fiocruz Genome Comparison Project

The Genome Comparison project is sponsored by the Brazilian research institution Fiocruz.[50] The project was launched on November 21, 2006,[44] and completed on July 21, 2007.[44] The project seeks to compare gene sequences of different organisms against each other in order to find similarities between them. Scientists hope to discover what purpose a particular gene sequence serves in a particular function of one organism, via comparing it to a similar gene sequence of known function in another organism.[51]

Help Cure Muscular Dystrophy – Phase 1

Main article: Help Cure Muscular Dystrophy

Help Cure Muscular Dystrophy is run by Décrypthon, a collaboration between French Muscular Dystrophy Association, French National Center for Scientific Research and IBM. Phase 1 was launched on December 19, 2006,[50] and completed on June 11, 2007.[52] The project investigated protein-protein interactions for 40,000 proteins whose structures are known, with particular focus on those proteins that play a role in neuromuscular diseases. The database of information produced will help researchers design molecules to inhibit or enhance binding of particular macromolecules, hopefully leading to better treatments for muscular dystrophy and other neuromuscular diseases.[53] This project was available only to agents running the Grid MP client, making it unavailable to users running BOINC.[54]

Discovering Dengue Drugs – Together

Main article: Discovering Dengue Drugs – Together

Discovering Dengue Drugs – Together is sponsored by scientists at the University of Texas and the University of Chicago and will run in two phases.[55] Phase 1, launched August 21, 2007,[50] used AutoDock 2007 (the same software used for FightAIDS@Home) to test potential antiviral drugs (through NS3 protease inhibition) against viruses from the family flaviviridae and completed on August 11, 2009.[56][57] Phase 2 "[uses] a more computationally intensive program to screen the candidates that make it through Phase 1."[58] The drug candidates that make it through Phase 2 will then be lab-tested.[58]

The Clean Energy Project – Phase 1

Main article: Clean Energy Project

The Clean Energy project is sponsored by the scientists of Harvard University's Department of Chemistry and Chemical Biology.[36] Phase 1 was launched on December 5, 2008, and completed on October 13, 2009.[59] The mission of the Clean Energy Project is to find new materials for the next generation of solar cells and later, energy storage devices. Researchers are employing molecular mechanics and electronic structure calculations to predict the optical and transport properties of molecules that could become the next generation of solar cell materials. By harnessing the computing power of the World Community Grid, researchers were able to calculate the electronic properties of tens of thousands of organic materials – many more than could ever be tested in a lab – and determine which candidates are most promising for developing affordable solar energy technology.[60]

Main article: Influenza Antiviral Drug Search

Influenza Antiviral Drug Search project is sponsored by Dr. Stan Watowich and his research team at The University of Texas Medical Branch (Galveston, Texas, USA).[61] The project was launched on May 5, 2009, and completed on October 22, 2009.[62] The mission of the Influenza Antiviral Drug Search project is to find new drugs that can stop the spread of an influenza infection in the body. The research will specifically address the influenza strains that have become drug resistant as well as new strains that are appearing. Identifying the chemical compounds that are the best candidates will accelerate the efforts to develop treatments that would be useful in managing seasonal influenza outbreaks, and future influenza epidemics and even pandemics.[63] Phase 1 of The Influenza Antiviral Drug Search project has already finished on October 22, 2009. Now the researchers are performing post-processing on the results from Phase 1 and are preparing for Phase 2.[62]

Nutritious Rice for the World

Main article: Nutritious Rice for the World

The Nutritious Rice for the World project is carried out by Ram Samudrala's Computational Biology Research Group at the University of Washington. The project was launched on May 12, 2008, and completed on April 6, 2010.[64] The purpose of this project is to predict the structure of proteins of major strains of rice, in order to help farmers breed better rice strains with higher crop yields, promote greater disease and pest resistance, and utilize a full range of bioavailable nutrients that can benefit people around the world, especially in regions where malnutrition is a critical concern. The project has been covered by more than 200 media outlets since its inception.[65] On April 13, 2010, World Community Grid officially announced that the Nutritious Rice for the World project finished on April 6, 2010.[64]

Help Cure Muscular Dystrophy – Phase 2

Main article: Help Cure Muscular Dystrophy

World Community Grid and researchers supported by Decrypthon, a partnership between AFM (French Muscular Dystrophy Association), CNRS (French National Center for Scientific Research), Universite Pierre et Marie Curie, and IBM were investigating protein-protein interactions for more than 2,200 proteins whose structures are known, with particular focus on those proteins that play a role in neuromuscular diseases. Phase 2 was launched on May 12, 2009,[66] and completed on September 26, 2012. The database of information produced will help researchers design molecules to inhibit or enhance binding of particular macromolecules, hopefully leading to better treatments for muscular dystrophy and other neuromuscular diseases.[67]

Phase 2 of the Help Cure Muscular Dystrophy project began once the results from the first phase had been analyzed. Phase 2 ran on the BOINC platform.[20][68]

Computing for Sustainable Water

Computing for Sustainable Water was the 21st research project to be launched on World Community Grid. The researchers at the University of Virginia were running this project on World Community Grid to study the effects of human activity on a large watershed and gain deeper insights into what actions can support the restoration, health and sustainability of this important water resource.[69] The project was launched on April 17, 2012,[70] and completed on October 17, 2012.

Discovering Dengue Drugs – Together – Phase 2

Main article: Discovering Dengue Drugs - Together

Discovering Dengue Drugs – Together – Phase 2 (launched February 17, 2010[71]) is sponsored by The University of Texas Medical Branch (UTMB) in Galveston, Texas, USA and the University of Chicago in Illinois, USA. The mission is to identify promising drug candidates to combat the Dengue, Hepatitis C, West Nile, Yellow Fever, and other related viruses. The extensive computing power of World Community Grid will be used to complete the structure-based drug discovery calculations required to identify these drug candidates.[72]

The project finished on March 2013. The latest update is available here. Chemical compounds have been discovered to inhibit both dengue and West Nile virus proteases. A handful of analogs developed from the initial computer-discovered dengue leads have entered crucial pre-clinical pharmacokinetic and efficacy studies

Help Conquer Cancer

Main article: Help Conquer Cancer

Help Conquer Cancer project (launched November 1, 2007[73]) is sponsored by the Ontario Cancer Institute (OCI), Princess Margaret Hospital and University Health Network of Toronto, Canada. The project involves X-ray crystallography. The mission of Help Conquer Cancer is to improve the results of protein X-ray crystallography, which helps researchers not only annotate unknown parts of the human proteome, but importantly improves their understanding of cancer initiation, progression and treatment.[74]

The HCC project was the first WCG project benefiting from GPU's which helped finish it a lot earlier than initially projected due to the massive power of GPU's. In the April 2013 status report, available here, the scientists report there is still a lot of data to analyze but that they are preparing a new project that will search for prognostic and predictive signatures (sets of genes, proteins, microRNAs, etc.) that help predict patient survival and response to treatment. The project finished on May 2013.

GO Fight Against Malaria Project

The mission of the GO Fight Against Malaria project (launched November 16, 2011[75]) is to discover promising drug candidates that could be developed into new drugs that cure drug resistant forms of malaria. The computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins, to predict their ability to eliminate malaria. The best compounds will be tested by scientists at The Scripps Research Institute of La Jolla, California, U.S.A. and further developed into possible treatments for the disease.[76]

In the latest status report, published on November 2012 and available here, the scientists reported that several compounds had been found to inhibit the virus activity. 20 compounds were ordered, 19 actually arrived, of which 3 were not soluble. From the remaining 16, 7 inhibited Mtb InhA(Mycobacterium tuberculosis). The best hit displayed an IC50 value of approximately 40 micro-Molar. The discovery of this compound is important because of the drug resistant superbugs of Mycobacterium tuberculosis.

On May 22, it was announced that the project was entering the final stages and should finish soon.

Human Proteome Folding – Phase 2

Main article: Human Proteome Folding Project

Human Proteome Folding - Phase 2 (HPF2) (launched June 23, 2006[50]) was the third project to run on World Community Grid. This project, following on from HPF1, focuses on human-secreted proteins, with special focus on biomarkers and the proteins on the surface of cells as well as Plasmodium, the organism that causes malaria. HPF2 generates higher-resolution protein models than HPF1. Though these higher-resolution models are more useful, they also require more processing power to generate.[77]

In a July 2012 status report, the project scientists reported that the results generated by the WCG calculations are being used by Dr. Markus Landthaler of the Max Delbruch Center for Molecular Medicine (MDC) in Berlin. The HPF2 results helped Dr. Markus Landthaler and his collaborators in writing up a new paper on "The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts" available here. More papers describing the results of the HPF2 project are available at its website.

Drug Search for Leishmaniasis

Drug Search for Leishmaniasis (launched September 7, 2011[78]) is spearheaded by the University of Antioquia in Medellín, Colombia, with assistance from researchers at the University of Texas Medical Branch in Galveston, Texas. The mission is to identify potential molecule candidates that could possibly be developed into treatments for Leishmaniasis. The extensive computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins. This will help find the most promising compounds that may lead to effective treatments for the disease.[79]

Inactive projects

AfricanClimate@Home

The mission of AfricanClimate@Home is to develop more accurate climate models of specific regions in Africa. This will serve as a basis for understanding how the climate will change in the future so that measures designed to alleviate the adverse effects of climate change can be implemented. World Community Grid's tremendous computing power will be used to understand and reduce the uncertainty with which climate processes are simulated over Africa. Phase 1 of African Climate@Home launched on September 3, 2007,[80] and ended in July 2008.[81] There are currently no plans for a 2nd phase.

References

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  2. ^ a b c d e f g "World Community Grid Credit overview". BOINCstats. Retrieved 24 August 2013.
  3. ^ a b c "About Us". World Community Grid. Retrieved 28 July 2007.
  4. ^ a b "System Requirements". Help. World Community Grid. Retrieved 28 July 2007.
  5. ^ "get_project_config.php". World Community Grid. Retrieved 28 July 2007.
  6. ^ "16 11 2010, Happy 6th Birthday, World Community Grid!". World Community Grid. 16 November 2010. Retrieved 17 November 2010.
  7. ^ a b c "Global Statistics". World Community Grid. Retrieved 17 June 2013.
  8. ^ IBM builds grid for smallpox research
  9. ^ a b "Computers enlisted for bioterror fight". BBC. 5 February 2003. Retrieved 24 November 2008.
  10. ^ Clery, Daniel (2005). "IBM Offers Free Number Crunching for Humanitarian Research Projects". Science. 308 (5723): 773a. doi:10.1126/science.308.5723.773a. Retrieved 24 November 2008.
  11. ^ knreed (31 October 2005). "Linux is here!!!". World Community Grid. Retrieved 30 July 2007.
  12. ^ BOINC Migration Announcement
  13. ^ a b Weiss, Todd (2004-11-17). "'World Community Grid' seeks to harness unused computers". Computerworld. Retrieved 2007-07-28.
  14. ^ "Member Policy". Privacy and Security. World Community Grid. Retrieved 2007-07-28.
  15. ^ "Returning Results: What is a Work Unit?". Help. World Community Grid. Retrieved 2007-08-05.
  16. ^ "Installing the Windows Agent: If I re-install the software, will the work that I am doing be lost forever?". Help. World Community Grid. Retrieved 2007-08-05.
  17. ^ "The Grid". Tryscience. Retrieved 2007-07-28.
  18. ^ "Points: What is validation?". Help. World Community Grid. Retrieved 2007-07-28.
  19. ^ "Getting Started: I'm using the BOINC agent, how do I choose which project my computer processes work for?". Help. World Community Grid. Retrieved 2007-08-05.
  20. ^ a b bbover3 (2007-08-17). "BOINC Migration Announcement". World Community Grid. Retrieved 2007-08-17.{{cite web}}: CS1 maint: numeric names: authors list (link)
  21. ^ "Agent: I have a platform that isn't supported by World Community Grid. Could I receive the code and compile it myself?". Help. World Community Grid. Retrieved 2007-08-05.
  22. ^ "CPU Usage: Why does my PC show high CPU use?". Help. World Community Grid. Retrieved 2007-08-05.
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  26. ^ "Teams". Help. World Community Grid. Retrieved 2007-07-28.
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