Cytophagic histiocytic panniculitis: Difference between revisions
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{{mergeto|Panniculitis|date=August 2013}} |
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'''Cytophagic Histiocytic Panniculitis''' ('''CHP''') was first described in 1980 by Winkelmann as a chronic [[histiocytic]] disease of the [[subcutaneous]] [[adipose tissue]], which is characterized clinically by tender [[erythematous]] [[Nodule (medicine)|nodules]], recurrent high [[fever]], [[malaise]], [[jaundice]], [[organomegaly]], [[serosal]] effusions, [[pancytopenia]], [[hepatic]] dysfunction and [[Coagulation]] abnormalities.<ref>Winkelmann RK, Bowie EJ. Hemorrhagic diathesis associated with benign histiocytic cytophagic panniculitis and systemic histiocytosis. Arch Intern Med.1980; 140: 1460-3</ref><ref name="Andrews">{{cite book |author=James, William D.; Berger, Timothy G.; et al. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |location= |year=2006 |pages= |isbn=0-7216-2921-0 |oclc= |doi= |accessdate=}}</ref>{{rp|494}} CHP may occur either isolated or as part of cutaneous manifestations of [[Hemophagocytic syndrome]] (HPS).<ref>Smith K J, Skeleton H J, Yeagre J, Angritt P, Wagner K, James W. D., Giblin W. J., Lupton G. P. Cutaneous histopathological, immunohistochemical, and clinical manifestations inpatients with hemophagocytic syndrome. Military Medical Consortium for Applied Retroviral Research (MMCARR). Arch Dermatol 1992; 128: 193-200</ref> CHP is a rare and often fatal form of [[panniculitis]] with multisystem involvement. But it can also present in a benign form involving only the subcutaneous tissue, thus having a broad clinical spectrum. |
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== See also == |
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* [[Panniculitis]] |
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* [[List of cutaneous conditions]] |
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== References == |
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{{Reflist}} |
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{{Cutaneous-condition-stub}} |
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{{Disorders of subcutaneous fat}} |
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[[Category:Conditions of the subcutaneous fat]] |
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Latest revision as of 00:25, 20 October 2013
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