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Revision as of 06:04, 16 November 2013

For other people named Richard Durbin (disambiguation)|Richard Durbin, see Richard Durbin (disambiguation).
Richard Durbin
Richard Durbin in his office at WTSI by Cory Doctorow
Born (1960-12-30) 30 December 1960 (age 63)[5]
NationalityBritish
Alma materSt John's College, Cambridge
Known forbioinformatics and computational biology
SpouseJulie Ahringer[5]
AwardsEMBO member (2009)[1]
Mullard Award (1994)
Fellow of the Royal Society (2004)
Doctor of Philosophy[2]
Scientific career
FieldsGenomics
Bioinformatics
Human genetics
Computational biology[3]
InstitutionsUniversity of Cambridge,
Laboratory of Molecular Biology,
Harvard University,
Wellcome Trust Sanger Institute
Highgate School
King's College, Cambridge
ThesisStudies on the development and organisation of the nervous system of Caenorhabditis elegans (1987)
Doctoral advisorJohn G. White[2]
Doctoral studentsEwan Birney[4]
Other notable studentsSean Eddy
Heng Li
(postdocs)
Websitesanger.ac.uk/research/faculty/rdurbin

Richard Michael Durbin, FRS, born (1960-12-30) 30 December 1960 (age 63),[5] is a British computational biologist. He is joint head of Human genetics at the Wellcome Trust Sanger Institute and leader of the Genome Informatics group.[6]

Education

Durbin was educated at The Hall School Hampstead and Highgate School in London.[5] After competing in the 1978/9 International Mathematical Olympiad,[7] he graduated from the University of Cambridge in 1982[8] with a first class honours degree on the Cambridge Mathematical Tripos and went on to obtain his PhD[2] in 1987 registered at St John's College, Cambridge[5] studying the development and organisation of the nervous system of Caenorhabditis elegans[9] whilst working at the Laboratory of Molecular Biology (LMB) in Cambridge.

Research

Durbin's early work included developing the primary instrument software for one of the first X-ray crystallography area detectors [10] and the MRC Biorad confocal microscope, alongside contributions to neural modelling.[11][12]

He then led the informatics for the C. elegans genome project,[13] and alongside Jean Thierry-Mieg developed the genome database AceDB, which evolved into the WormBase web resource. Following this he played an important role in data collection for and interpretation of the human genome sequence.[14]

He has developed numerous methods for computational sequence analysis.[15][16] These include gene finding (e.g. GeneWise) with Ewan Birney[17] and Hidden Markov models for protein and nucleic acid alignment and matching (e.g. HMMER) with Sean Eddy and Graeme Mitchison. A standard textbook "Biological Sequence Analysis" coauthored with Sean Eddy, Anders Krogh and Graeme Mitchison[18] describes some of this work. Using these methods Durbin worked with colleagues to build a series of important genomic data resources, including the protein family database Pfam,[19] the genome database Ensembl,[20] and the gene family database TreeFam.[21]

More recently Durbin has returned to sequencing and has developed low coverage approaches to population genome sequencing, applied first to yeast,[22][23] and has been one of the leaders in the application of new sequencing technology to study human genome variation.[24][25] Durbin currently co-leads the international 1000 Genomes Project to characterise variation down to 1% allele frequency as a foundation for human genetics.

Awards

Durbin was a joint winner of the Mullard Award of the Royal Society in 1994 (for work on the confocal microscope), won the Lord Lloyd of Kilgerran Award of the Foundation for Science and Technology in 2004, and was elected a Fellow of the Royal Society in 2004[3][26][27] and a member of the European Molecular Biology Organization (EMBO) in 2009.

Durbin's candidacy for the Royal Society reads:

"Durbin is distinguished for his powerful contribution to computational biology. In particular, he played a leading role in establishing the new field of bioinformatics. This allows the handling of biological data on an unprecedented scale, enabling genomics to prosper. He led the analysis of the C. elegans genome, and with Thierry-Mieg developed the database software ACEDB. In the international genome project he led the analysis of protein coding genes. He introduced key computational tools in software and data handling. His Pfam database allowed the identification of domains in new protein sequences; it used hidden Markov models to which approach generally he brought rigour and which led to covariance models for RNA sequence.."[28]

Personal

Durbin is the son of James Durbin and is married to Julie Ahringer,[5] a scientist at the Gurdon Institute. He has two children.

References

  1. ^ http://www.biochemist.org/society/page.htm?item=37150 EMBO welcomes 66 leading life scientists as members
  2. ^ a b c Durbin, Richard (1987). Studies on the development and organisation of the nervous system of Caenorhabditis elegans (PhD thesis). University of Cambridge.
  3. ^ a b Richard M. Durbin publications indexed by Google Scholar
  4. ^ Birney, Ewan (2000). Sequence alignment in bioinformatics (DPhil thesis). University of Cambridge.
  5. ^ a b c d e f "DURBIN, Richard Michael". Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press.(subscription required)
  6. ^ "Dr Richard Durbin - Wellcome Trust Sanger Institute". Archived from the original on 2012-03-05.
  7. ^ Richard M. Durbin's results at International Mathematical Olympiad
  8. ^ "The BioInformer nr. 1, 1997 -- Interview with Dr. Richard Durbin". Archived from the original on 2011-07-30. Retrieved 2011-07-30.
  9. ^ Durbin, Richard (1987). Studies on the development and organisation of the nervous system of Caenorhabditis elegans (Ph.D. thesis). University of Cambridge.
  10. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 3704639, please use {{cite journal}} with |pmid=3704639 instead.
  11. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 3561510, please use {{cite journal}} with |pmid=3561510 instead.
  12. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 2304536, please use {{cite journal}} with |pmid=2304536 instead.
  13. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 9851916 , please use {{cite journal}} with |pmid=9851916 instead.
  14. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11237011, please use {{cite journal}} with |pmid=11237011 instead.
  15. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22156294, please use {{cite journal}} with |pmid=22156294 instead.
  16. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15892872, please use {{cite journal}} with |pmid=15892872 instead.
  17. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 10779496, please use {{cite journal}} with |pmid=10779496 instead.
  18. ^ Durbin, Richard M.; Eddy, Sean R.; Krogh, Anders; Mitchison, Graeme (1998), Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids (1st ed.), Cambridge, New York: Cambridge University Press, ISBN 0-521-62971-3, OCLC 593254083
  19. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 9223186, please use {{cite journal}} with |pmid=9223186 instead.
  20. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11752248, please use {{cite journal}} with |pmid=11752248 instead.
  21. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16381935, please use {{cite journal}} with |pmid=16381935 instead.
  22. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19212322, please use {{cite journal}} with |pmid=19212322 instead.
  23. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21698134, please use {{cite journal}} with |pmid=21698134 instead.
  24. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18987734, please use {{cite journal}} with |pmid=18987734 instead.
  25. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21753753, please use {{cite journal}} with |pmid=21753753 instead.
  26. ^ Richard M. Durbin publications indexed by Microsoft Academic
  27. ^ Richard M. Durbin at DBLP Bibliography Server Edit this at Wikidata
  28. ^ "Library and Archive Catalogue". London: The Royal Society. Retrieved 2013-11-14.

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