Cyclic guanosine monophosphate–adenosine monophosphate: Difference between revisions
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[[File:2'3'-cGAMP.jpg|thumb| |
[[File:2'3'-cGAMP.jpg|thumb|cyclic GMP-AMP structure]] |
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'''Cyclic guanosine monophosphate–adenosine monophosphate''' (cyclic GMP-AMP, cGMP-AMP, cGAMP, cyclic GAMP) is the first [[cyclic di-nucleotide]] identified in [[metazoa]].<ref name="pmid23258412">{{cite journal|last=Wu|first=J|coauthors=Sun, L; Chen, X; Du, F; Shi, H; Chen, C; Chen, ZJ|title=Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.|journal=Science (New York, N.Y.)|date=2013 Feb 15|volume=339|issue=6121|pages=826–30|pmid=23258412}}</ref> cGAMP has also been identified in the [[Vibrio cholerae|Vibro cholerae]] and shown to play a role in bacterial [[chemotaxis]] and [[colonization]].<ref>{{cite journal|last=Davies|first=BW|coauthors=Bogard, RW; Young, TS; Mekalanos, JJ|title=Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence.|journal=Cell|date=2012 Apr 13|volume=149|issue=2|pages=358–70|pmid=22500802}}</ref> |
'''Cyclic guanosine monophosphate–adenosine monophosphate''' (cyclic GMP-AMP, cGMP-AMP, cGAMP, cyclic GAMP) is the first [[cyclic di-nucleotide]] identified in [[metazoa]].<ref name="pmid23258412">{{cite journal|last=Wu|first=J|coauthors=Sun, L; Chen, X; Du, F; Shi, H; Chen, C; Chen, ZJ|title=Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.|journal=Science (New York, N.Y.)|date=2013 Feb 15|volume=339|issue=6121|pages=826–30|pmid=23258412}}</ref> cGAMP has also been identified in the [[Vibrio cholerae|Vibro cholerae]] and shown to play a role in bacterial [[chemotaxis]] and [[colonization]].<ref>{{cite journal|last=Davies|first=BW|coauthors=Bogard, RW; Young, TS; Mekalanos, JJ|title=Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence.|journal=Cell|date=2012 Apr 13|volume=149|issue=2|pages=358–70|pmid=22500802}}</ref> |
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Revision as of 00:31, 30 December 2013
Cyclic guanosine monophosphate–adenosine monophosphate (cyclic GMP-AMP, cGMP-AMP, cGAMP, cyclic GAMP) is the first cyclic di-nucleotide identified in metazoa.[1] cGAMP has also been identified in the Vibro cholerae and shown to play a role in bacterial chemotaxis and colonization.[2]
In human and mouse cells, cGAMP is synthesized by Cyclic GMP-AMP synthase (cGAS) from ATP and GTP upon cytosolic DNA stimulation. cGAMP functions as an second messenger inducing STING-dependent type I interferon response.[1][3]
References
- ^ a b Wu, J (2013 Feb 15). "Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA". Science (New York, N.Y.). 339 (6121): 826–30. PMID 23258412.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Davies, BW (2012 Apr 13). "Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence". Cell. 149 (2): 358–70. PMID 22500802.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Sun, L (2013 Feb 15). "Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway". Science (New York, N.Y.). 339 (6121): 786–91. PMID 23258413.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help)