Cyclic guanosine monophosphate–adenosine monophosphate: Difference between revisions
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[[File:2'3'-cGAMP.jpg|thumb|cyclic GMP-AMP structure]] |
[[File:2'3'-cGAMP.jpg|thumb|cyclic GMP-AMP structure]] |
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'''cyclic GMP-AMP''' (cGAMP) is identified by James Chen's Group at UT southwestern as the first [[cyclic di-nucleotide]] in [[metazoa]].<ref name="pmid23258412">{{cite journal|last=Wu|first=J|coauthors=Sun, L; Chen, X; Du, F; Shi, H; Chen, C; Chen, ZJ|title=Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.|journal=Science (New York, N.Y.)|date=2013 Feb 15|volume=339|issue=6121|pages=826–30|pmid=23258412}}</ref> |
'''cyclic GMP-AMP''' (cGAMP) is identified by James Chen's Group at UT southwestern as the first [[cyclic di-nucleotide]] in [[metazoa]].<ref name="pmid23258412">{{cite journal|last=Wu|first=J|coauthors=Sun, L; Chen, X; Du, F; Shi, H; Chen, C; Chen, ZJ|title=Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.|journal=Science (New York, N.Y.)|date=2013 Feb 15|volume=339|issue=6121|pages=826–30|pmid=23258412}}</ref> |
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In human and mouse cells, cGAMP is synthesized by [[Cyclic GMP-AMP synthase]] (cGAS) from [[Adenosine triphosphate|ATP]] and [[Guanosine triphosphate|GTP]] upon cytosolic DNA stimulation <ref>{{cite journal|last=Sun|first=L|coauthors=Wu, J; Du, F; Chen, X; Chen, ZJ|title=Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway|journal=Science (New York, N.Y.)|date=2013 Feb 15|volume=339|issue=6121|pages=786–91|pmid=23258413}}</ref>. cGAMP produced by cGAS contained mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP.<ref>{{cite journal|last=Zhang|first= |
In human and mouse cells, cGAMP is synthesized by [[Cyclic GMP-AMP synthase]] (cGAS) from [[Adenosine triphosphate|ATP]] and [[Guanosine triphosphate|GTP]] upon cytosolic DNA stimulation <ref>{{cite journal|last=Sun|first=L|coauthors=Wu, J; Du, F; Chen, X; Chen, ZJ|title=Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway|journal=Science (New York, N.Y.)|date=2013 Feb 15|volume=339|issue=6121|pages=786–91|pmid=23258413}}</ref>. cGAMP produced by cGAS contained mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP.<ref name=Zhang>{{cite journal|last=Zhang|first=Xu|coauthors=Shi, H; Wu, J; Zhang, X; Sun, L; Chen, C; Chen, ZJ|journal=Molecular Cell|date=2013 June 3|volume=51|pages=226-235|pmid=https://en.wikipedia.org/enwiki/w/index.php?title=Cyclic_guanosine_monophosphate%E2%80%93adenosine_monophosphate&action=submit#}}</ref> This molecule,abbreviated as 2′3′-cGAMP, functions as an endogenous [[second messenger]] inducing STING-dependent [[Interferon type I|type I interferon]] response.<ref name="pmid23258412"/> |
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== References == |
== References == |
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Revision as of 01:35, 30 December 2013
cyclic GMP-AMP (cGAMP) is identified by James Chen's Group at UT southwestern as the first cyclic di-nucleotide in metazoa.[1] In human and mouse cells, cGAMP is synthesized by Cyclic GMP-AMP synthase (cGAS) from ATP and GTP upon cytosolic DNA stimulation [2]. cGAMP produced by cGAS contained mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP.[3] This molecule,abbreviated as 2′3′-cGAMP, functions as an endogenous second messenger inducing STING-dependent type I interferon response.[1]
References
- ^ a b Wu, J (2013 Feb 15). "Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA". Science (New York, N.Y.). 339 (6121): 826–30. PMID 23258412.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Sun, L (2013 Feb 15). "Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway". Science (New York, N.Y.). 339 (6121): 786–91. PMID 23258413.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Zhang, Xu (2013 June 3). Molecular Cell. 51: 226–235. PMID https://en.wikipedia.org/enwiki/w/index.php?title=Cyclic_guanosine_monophosphate%E2%80%93adenosine_monophosphate&action=submit#.
{{cite journal}}: Check|pmid=value (help); Check date values in:|date=(help); External link in|pmid=|title=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help)