Cyclic guanosine monophosphate–adenosine monophosphate: Difference between revisions
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[[File:2'3'-cGAMP.jpg|thumb|cyclic GMP-AMP structure]] |
[[File:2'3'-cGAMP.jpg|thumb|cyclic GMP-AMP structure]] |
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'''Cyclic guanosine monophosphate–adenosine monophosphate''' (cyclic GMP-AMP, cGAMP) is identified by [[Zhijian James Chen]]'s Group at UT southwestern as the first [[cyclic di-nucleotide]] in [[metazoa]].<ref name="pmid23258412">{{cite journal|last=Wu|first=J|coauthors=Sun, L; Chen, X; Du, F; Shi, H; Chen, C; Chen, ZJ|title=Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.|journal=Science (New York, N.Y.)|date=2012 Dec 20|volume=339|issue=6121|pages=826–30|pmid=23258412}}</ref> |
'''Cyclic guanosine monophosphate–adenosine monophosphate''' (cyclic GMP-AMP, cGAMP) is identified by [[Zhijian James Chen]]'s Group at UT southwestern as the first [[cyclic di-nucleotide]] in [[metazoa]].<ref name="pmid23258412">{{cite journal|last=Wu|first=J|coauthors=Sun, L; Chen, X; Du, F; Shi, H; Chen, C; Chen, ZJ|title=Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.|journal=Science (New York, N.Y.)|date=2012 Dec 20|volume=339|issue=6121|pages=826–30|pmid=23258412}}</ref> |
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In human and mouse cells, cGAMP is synthesized by [[cyclic GMP-AMP synthase]] (cGAS) from [[Adenosine triphosphate|ATP]] and [[Guanosine triphosphate|GTP]] upon cytosolic DNA stimulation. <ref>{{cite journal|last=Sun|first=L|coauthors=Wu, J; Du, F; Chen, X; Chen, ZJ|title=Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway|journal=Science (New York, N.Y.)|date=2012 Dec 20|volume=339|issue=6121|pages=786–91|pmid=23258413}}</ref> cGAMP produced by cGAS contains mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP.<ref name=Zhang>{{cite journal|last=Zhang|first=X|coauthors=Shi, H; Wu, J; Zhang, X; Sun, L; Chen, C; Chen, ZJ|title=Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING|journal=Molecular Cell|date=2013 Jun 03|volume=51|issue=2|pages=226-235}}</ref><ref name=Gao>{{cite journal|last=Gao|first=P|coauthors=Ascano, M; Wu, Y; Barchet, W; Gaffney, BL et al|title=Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase|journal=Cell|date=2013 May 03|volume=153|issue=5|pages=1094-1107}}</ref><ref name=Ablasser>{{cite journal|last=Ablasser|first=A|coauthors=Goldeck, M; Cavlar, T; Deimling, T; Witte, G; Röhl, I; Hopfner, KP; Ludwig, J; Hornung, V|title=cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING|journal=Nature|date=2013 Jun 20|volume=498|issue=7454|pages=380-384}}</ref> This molecule,abbreviated as 2′3′-cGAMP, functions as an endogenous [[second messenger]] inducing STING-dependent [[Interferon type I|type I interferon]] response.<ref name="pmid23258412"/> <ref name=Zhang/> |
In human and mouse cells, cGAMP is synthesized by [[cyclic GMP-AMP synthase]] ([[cyclic GMP-AMP synthase|cGAS]]) from [[Adenosine triphosphate|ATP]] and [[Guanosine triphosphate|GTP]] upon cytosolic DNA stimulation. <ref>{{cite journal|last=Sun|first=L|coauthors=Wu, J; Du, F; Chen, X; Chen, ZJ|title=Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway|journal=Science (New York, N.Y.)|date=2012 Dec 20|volume=339|issue=6121|pages=786–91|pmid=23258413}}</ref> cGAMP produced by cGAS contains mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP.<ref name=Zhang>{{cite journal|last=Zhang|first=X|coauthors=Shi, H; Wu, J; Zhang, X; Sun, L; Chen, C; Chen, ZJ|title=Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING|journal=Molecular Cell|date=2013 Jun 03|volume=51|issue=2|pages=226-235}}</ref><ref name=Gao>{{cite journal|last=Gao|first=P|coauthors=Ascano, M; Wu, Y; Barchet, W; Gaffney, BL et al|title=Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase|journal=Cell|date=2013 May 03|volume=153|issue=5|pages=1094-1107}}</ref><ref name=Ablasser>{{cite journal|last=Ablasser|first=A|coauthors=Goldeck, M; Cavlar, T; Deimling, T; Witte, G; Röhl, I; Hopfner, KP; Ludwig, J; Hornung, V|title=cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING|journal=Nature|date=2013 Jun 20|volume=498|issue=7454|pages=380-384}}</ref> This molecule,abbreviated as 2′3′-cGAMP, functions as an endogenous [[second messenger]] inducing STING-dependent [[Interferon type I|type I interferon]] response.<ref name="pmid23258412"/> <ref name=Zhang/> |
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== References == |
== References == |
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Revision as of 03:55, 30 December 2013
Cyclic guanosine monophosphate–adenosine monophosphate (cyclic GMP-AMP, cGAMP) is identified by Zhijian James Chen's Group at UT southwestern as the first cyclic di-nucleotide in metazoa.[1] In human and mouse cells, cGAMP is synthesized by cyclic GMP-AMP synthase (cGAS) from ATP and GTP upon cytosolic DNA stimulation. [2] cGAMP produced by cGAS contains mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP.[3][4][5] This molecule,abbreviated as 2′3′-cGAMP, functions as an endogenous second messenger inducing STING-dependent type I interferon response.[1] [3]
References
- ^ a b Wu, J (2012 Dec 20). "Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA". Science (New York, N.Y.). 339 (6121): 826–30. PMID 23258412.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Sun, L (2012 Dec 20). "Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway". Science (New York, N.Y.). 339 (6121): 786–91. PMID 23258413.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ a b Zhang, X (2013 Jun 03). "Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING". Molecular Cell. 51 (2): 226–235.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Gao, P (2013 May 03). "Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase". Cell. 153 (5): 1094–1107.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Ablasser, A (2013 Jun 20). "cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING". Nature. 498 (7454): 380–384.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help)