IFIT proteins: Difference between revisions
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Revision as of 19:41, 10 January 2014
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IFIT proteins are produced in human body on stimulation by IFIT genes that are induced by IFN treatment, viral infection and Pathogen associated molecular pattern recognition.[1] So far, four families of this protein have been identified in humans which are IFIT1, IFIT2, IFIT3 and IFIT5. These proteins differ from each other in having different number of tetratricopeptide repeats(TPRs). The IFIT1 is known to possess 6 TPRs and IFIT2 has 4 TPRs. The IFIT proteins that are produced in humans and mouse are 40%-45% similar. It is thought that the Gene encoding IFIT protein in different species has a common ancestry.
Discovery
References
- ^ Diamond, Michael S. (14 December 2012). "The broad-spectrum antiviral functions of IFIT and IFITM proteins". Nature Reviews Immunology. 13 (1): 46–57. doi:10.1038/nri3344.
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