APOBEC4: Difference between revisions
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{{PBB|geneid=403314}} |
{{PBB|geneid=403314}} |
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'''C->U-editing enzyme APOBEC-4''', also known as '''Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4''', is a [[protein]] that in humans is encoded by the '''''APOBEC4''''' [[gene]].<ref name="pmid16082223">{{cite journal | author = Rogozin IB, Basu MK, Jordan IK, Pavlov YI, Koonin EV | title = APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis | journal = Cell Cycle | volume = 4 | issue = 9 | pages = 1281–5 | |
'''C->U-editing enzyme APOBEC-4''', also known as '''Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4''', is a [[protein]] that in humans is encoded by the '''''APOBEC4''''' [[gene]].<ref name="pmid16082223">{{cite journal | author = Rogozin IB, Basu MK, Jordan IK, Pavlov YI, Koonin EV | title = APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis | journal = Cell Cycle | volume = 4 | issue = 9 | pages = 1281–5 |date=September 2005 | pmid = 16082223 | doi = | url = | issn = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: apolipoprotein B mRNA editing enzyme| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=403314| accessdate = }}</ref> |
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== Function == |
== Function == |
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Revision as of 01:36, 14 January 2014
Template:PBB C->U-editing enzyme APOBEC-4, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4, is a protein that in humans is encoded by the APOBEC4 gene.[1][2]
Function
This gene encodes a member of the AID / APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection.[2]
References
- ^ Rogozin IB, Basu MK, Jordan IK, Pavlov YI, Koonin EV (September 2005). "APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis". Cell Cycle. 4 (9): 1281–5. PMID 16082223.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b "Entrez Gene: apolipoprotein B mRNA editing enzyme".
Further reading
- Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Prochnow C, Bransteitter R, Chen XS (2009). "APOBEC deaminases-mutases with defensive roles for immunity". Sci. China, C, Life Sci. 52 (10): 893–902. doi:10.1007/s11427-009-0133-1. PMID 19911124.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.