IFIT proteins: Difference between revisions

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IFIT proteins are produced in human body that are supposed to confer immunity against viral infection. These proteins are generally produced during viral infection, IFN treatment, and Pathogen associated molecular pattern recognition.^[1] So far, four families of this protein have been identified in humans which are IFIT1, IFIT2, IFIT3 and IFIT5. These proteins differ from each other in having different number of tetratricopeptide repeats(TPRs). The IFIT1 is known to possess 6 TPRs and IFIT2 has 4 TPRs. The IFIT proteins that are produced in humans and mouse are 40%-45% similar. It is thought that the Gene encoding IFIT protein in different species has a common ancestry.

Discovery

References

^ Diamond, Michael S. (14 December 2012). "The broad-spectrum antiviral functions of IFIT and IFITM proteins". Nature Reviews Immunology. 13 (1): 46–57. doi:10.1038/nri3344. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

[1] Diamond, Michael S. (14 December 2012). "The broad-spectrum antiviral functions of IFIT and IFITM proteins". Nature Reviews Immunology. 13 (1): 46–57. doi:10.1038/nri3344. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

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-'''IFIT proteins''' are produced in human body on stimulation by IFIT genes that are induced by [[IFN]] treatment, viral infection and [[Pathogen-associated molecular pattern|Pathogen associated molecular pattern recognition]].<ref>{{cite journal|last=Diamond|first=Michael S.|coauthors=Farzan, Michael|title=The broad-spectrum antiviral functions of IFIT and IFITM proteins|journal=Nature Reviews Immunology|date=14 December 2012|volume=13|issue=1|pages=46–57|doi=10.1038/nri3344}}</ref> So far, four families of this protein have been identified in humans which are IFIT1, IFIT2, IFIT3 and IFIT5. These proteins differ from each other in having different number of [[Tetratricopeptide|tetratricopeptide repeats(TPRs)]]. The IFIT1 is known to possess 6 TPRs and IFIT2 has 4 TPRs.  The IFIT proteins that are produced in humans and mouse are 40%-45% similar. It is thought that the Gene encoding IFIT protein in different species has a common ancestry.<br />
+'''IFIT proteins''' are produced in human body that are supposed to confer immunity against viral infection. These proteins are generally produced during viral infection, [[IFN]] treatment,  and [[Pathogen-associated molecular pattern|Pathogen associated molecular pattern recognition]].<ref>{{cite journal|last=Diamond|first=Michael S.|coauthors=Farzan, Michael|title=The broad-spectrum antiviral functions of IFIT and IFITM proteins|journal=Nature Reviews Immunology|date=14 December 2012|volume=13|issue=1|pages=46–57|doi=10.1038/nri3344}}</ref> So far, four families of this protein have been identified in humans which are IFIT1, IFIT2, IFIT3 and IFIT5. These proteins differ from each other in having different number of [[Tetratricopeptide|tetratricopeptide repeats(TPRs)]]. The IFIT1 is known to possess 6 TPRs and IFIT2 has 4 TPRs.  The IFIT proteins that are produced in humans and mouse are 40%-45% similar. It is thought that the Gene encoding IFIT protein in different species has a common ancestry.<br />
 ==Discovery==