IFIT proteins: Difference between revisions
Amit.Vic99 (talk | contribs) No edit summary |
Amit.Vic99 (talk | contribs) No edit summary |
||
| Line 3: | Line 3: | ||
{{technical|date=January 2014}} |
{{technical|date=January 2014}} |
||
}} |
}} |
||
'''IFIT proteins''' are produced in human body that are supposed to confer immunity against viral infection. These proteins are generally produced during viral infection, [[IFN]] treatment, and [[Pathogen-associated molecular pattern|Pathogen associated molecular pattern recognition]].<ref>{{cite journal|last=Diamond|first=Michael S.|coauthors=Farzan, Michael|title=The broad-spectrum antiviral functions of IFIT and IFITM proteins|journal=Nature Reviews Immunology|date=14 December 2012|volume=13|issue=1|pages=46–57|doi=10.1038/nri3344}}</ref> So far, four families of this protein have been identified in humans which are IFIT1, IFIT2, IFIT3 and IFIT5. Birds, [[Marsupial|Marsupials]], Frogs and Fishes have been found to produce only IFIT5 type proteins. These proteins differ from each other in having different number of [[Tetratricopeptide|tetratricopeptide repeats(TPRs)]]. The IFIT1 is known to possess 6 TPRs and IFIT2 has 4 TPRs. The IFIT proteins that are produced in humans and mouse are 40%-45% similar. It is thought that the Gene encoding IFIT protein in different species has a common ancestry.<br /> |
'''IFIT proteins''' (Interferon Induced proteins with Tetratricopeptide repeats) are produced in human body that are supposed to confer immunity against viral infection. These proteins are generally produced during viral infection, Interferon ([[IFN]]) treatment, and during pathogen recognition ([[Pathogen-associated molecular pattern|Pathogen associated molecular pattern recognition]]) by [[immune system]] during infections.<ref>{{cite journal|last=Diamond|first=Michael S.|coauthors=Farzan, Michael|title=The broad-spectrum antiviral functions of IFIT and IFITM proteins|journal=Nature Reviews Immunology|date=14 December 2012|volume=13|issue=1|pages=46–57|doi=10.1038/nri3344}}</ref> So far, four families of this protein have been identified in humans which are IFIT1, IFIT2, IFIT3 and IFIT5. Birds, [[Marsupial|Marsupials]], Frogs and Fishes have been found to produce only IFIT5 type proteins. These proteins differ from each other in having different number of [[Tetratricopeptide|tetratricopeptide repeats(TPRs)]]. The IFIT1 is known to possess 6 TPRs and IFIT2 has 4 TPRs. The IFIT proteins that are produced in humans and mouse are 40%-45% similar. It is thought that the Gene encoding IFIT protein in different species has a common ancestry.<br /> |
||
==Discovery== |
==Discovery== |
||
Revision as of 09:42, 15 January 2014
 | This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these messages)
|
IFIT proteins (Interferon Induced proteins with Tetratricopeptide repeats) are produced in human body that are supposed to confer immunity against viral infection. These proteins are generally produced during viral infection, Interferon (IFN) treatment, and during pathogen recognition (Pathogen associated molecular pattern recognition) by immune system during infections.[1] So far, four families of this protein have been identified in humans which are IFIT1, IFIT2, IFIT3 and IFIT5. Birds, Marsupials, Frogs and Fishes have been found to produce only IFIT5 type proteins. These proteins differ from each other in having different number of tetratricopeptide repeats(TPRs). The IFIT1 is known to possess 6 TPRs and IFIT2 has 4 TPRs. The IFIT proteins that are produced in humans and mouse are 40%-45% similar. It is thought that the Gene encoding IFIT protein in different species has a common ancestry.
Discovery
References
- ^ Diamond, Michael S. (14 December 2012). "The broad-spectrum antiviral functions of IFIT and IFITM proteins". Nature Reviews Immunology. 13 (1): 46–57. doi:10.1038/nri3344.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help)