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IFIT proteins (Interferon Induced proteins with Tetratricopeptide repeats) are produced in human body that are supposed to confer immunity against viral infection. These proteins are generally produced during viral infection, Interferon (IFN) treatment, and during pathogen recognition (Pathogen associated molecular pattern recognition) by immune system during infections.^[1] So far, four families of this protein have been identified in humans which are IFIT1, IFIT2, IFIT3 and IFIT5. Birds, Marsupials, Frogs and Fishes have been found to produce only IFIT5 type proteins. These proteins differ from each other in having different number of tetratricopeptide repeats(TPRs). The IFIT1 is known to possess 6 TPRs and IFIT2 has 4 TPRs. The IFIT proteins that are produced in humans and mouse are 40%-45% similar. It is thought that the Gene encoding IFIT protein in different species has a common ancestry.

Origins of IFIT Proteins

IFIT proteins are produced when genes encoding IFIT proteins are induced by Interferon. IFIT proteins are known to have originated in vertebrates about 450 million years ago^[2].

References

^ Diamond, Michael S. (14 December 2012). "The broad-spectrum antiviral functions of IFIT and IFITM proteins". Nature Reviews Immunology. 13 (1): 46–57. doi:10.1038/nri3344. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
^ PLoS One. 2013 Jun 20;8(6):e66859. doi: 10.1371/journal.pone.0066859. Print 2013. Lineage-specific expansion of IFIT gene family: an insight into coevolution with IFN gene family. Liu Y, Zhang YB, Liu TK, Gui JF.

[1] Diamond, Michael S. (14 December 2012). "The broad-spectrum antiviral functions of IFIT and IFITM proteins". Nature Reviews Immunology. 13 (1): 46–57. doi:10.1038/nri3344. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

[2] PLoS One. 2013 Jun 20;8(6):e66859. doi: 10.1371/journal.pone.0066859. Print 2013. Lineage-specific expansion of IFIT gene family: an insight into coevolution with IFN gene family. Liu Y, Zhang YB, Liu TK, Gui JF.

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 '''IFIT proteins''' (Interferon Induced proteins with [[Tetratricopeptide]] repeats) are produced in human body that are supposed to confer immunity against viral infection. These proteins are generally produced during viral infection, Interferon ([[IFN]]) treatment,  and during pathogen recognition ([[Pathogen-associated molecular pattern|Pathogen associated molecular pattern recognition]]) by [[immune system]] during infections.<ref>{{cite journal|last=Diamond|first=Michael S.|coauthors=Farzan, Michael|title=The broad-spectrum antiviral functions of IFIT and IFITM proteins|journal=Nature Reviews Immunology|date=14 December 2012|volume=13|issue=1|pages=46–57|doi=10.1038/nri3344}}</ref> So far, four families of this protein have been identified in humans which are IFIT1, IFIT2, IFIT3 and IFIT5. Birds, [[Marsupial]]s, Frogs and Fishes have been found to produce only IFIT5 type proteins. These proteins differ from each other in having different number of [[Tetratricopeptide|tetratricopeptide repeats(TPRs)]]. The IFIT1 is known to possess 6 TPRs and IFIT2 has 4 TPRs.  The IFIT proteins that are produced in humans and mouse are 40%-45% similar. It is thought that the Gene encoding IFIT protein in different species has a common ancestry.
+== Origins of IFIT Proteins ==
+IFIT proteins are produced when genes encoding IFIT proteins are induced by Interferon. IFIT proteins are known to have originated in vertebrates about 450 million years ago<ref>PLoS One. 2013 Jun 20;8(6):e66859. doi: 10.1371/journal.pone.0066859. Print 2013. Lineage-specific expansion of IFIT gene family: an insight into coevolution with IFN gene family. Liu Y, Zhang YB, Liu TK, Gui JF.</ref>.
 ==References==
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