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==Interactions==
==Interactions==
SMC3 (gene) has been shown to [[Protein-protein interaction|interact]] with [[REC8]],<ref name=pmid12759374>{{cite journal |last=Lee |first=Jibak |authorlink= |coauthors=Iwai Toshiharu, Yokota Takehiro, Yamashita Masakane |date=July 2003 |title=Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis |journal=J. Cell. Sci. |volume=116 |issue=Pt 13 |pages=2781–90 |publisher= |location = England| issn = 0021-9533| pmid = 12759374 |doi = 10.1242/jcs.00495 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MXD1]],<ref name=pmid9528857>{{cite journal |last=Gupta |first=K |authorlink= |coauthors=Anand G, Yin X, Grove L, Prochownik E V |date=March 1998 |title=Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc |journal=Oncogene |volume=16 |issue=9 |pages=1149–59 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 9528857 |doi = 10.1038/sj.onc.1201634 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[KIFAP3]],<ref name=pmid9506951>{{cite journal |last=Shimizu |first=K |authorlink= |coauthors=Shirataki H, Honda T, Minami S, Takai Y |year=1998|month=March |title=Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide |journal=J. Biol. Chem. |volume=273 |issue=12 |pages=6591–4 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9506951 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.273.12.6591 }}</ref> [[MXI1]]<ref name=pmid9528857/> and [[SMC1A]].<ref name=pmid12759374/><ref name=pmid11877376>{{cite journal |last=Kim |first=Seong-Tae |authorlink= |coauthors=Xu Bo, Kastan Michael B |year=2002|month=March |title=Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage |journal=Genes Dev. |volume=16 |issue=5 |pages=560–70 |publisher= |location = United States| issn = 0890-9369| pmid = 11877376 |doi = 10.1101/gad.970602 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=155347 }}</ref><ref name=pmid9789013>{{cite journal |last=Schmiesing |first=J A |authorlink= |coauthors=Ball A R, Gregson H C, Alderton J M, Zhou S, Yokomori K |year=1998|month=October |title=Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=95 |issue=22 |pages=12906–11 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9789013 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.95.22.12906 |pmc=23650 }}</ref><ref name=pmid11590136>{{cite journal |last=Gregson |first=H C |authorlink= |coauthors=Schmiesing J A, Kim J S, Kobayashi T, Zhou S, Yokomori K |year=2001|month=Dec |title=A potential role for human cohesin in mitotic spindle aster assembly |journal=J. Biol. Chem. |volume=276 |issue=50 |pages=47575–82 |publisher= |location = United States| issn = 0021-9258| pmid = 11590136 |doi = 10.1074/jbc.M103364200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
SMC3 (gene) has been shown to [[Protein-protein interaction|interact]] with [[REC8]],<ref name=pmid12759374>{{cite journal |last=Lee |first=Jibak |authorlink= |coauthors=Iwai Toshiharu, Yokota Takehiro, Yamashita Masakane |date=July 2003 |title=Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis |journal=J. Cell. Sci. |volume=116 |issue=Pt 13 |pages=2781–90 |publisher= |location = England| issn = 0021-9533| pmid = 12759374 |doi = 10.1242/jcs.00495 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MXD1]],<ref name=pmid9528857>{{cite journal |last=Gupta |first=K |authorlink= |coauthors=Anand G, Yin X, Grove L, Prochownik E V |date=March 1998 |title=Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc |journal=Oncogene |volume=16 |issue=9 |pages=1149–59 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 9528857 |doi = 10.1038/sj.onc.1201634 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[KIFAP3]],<ref name=pmid9506951>{{cite journal |last=Shimizu |first=K |authorlink= |coauthors=Shirataki H, Honda T, Minami S, Takai Y |date=March 1998 |title=Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide |journal=J. Biol. Chem. |volume=273 |issue=12 |pages=6591–4 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9506951 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.273.12.6591 }}</ref> [[MXI1]]<ref name=pmid9528857/> and [[SMC1A]].<ref name=pmid12759374/><ref name=pmid11877376>{{cite journal |last=Kim |first=Seong-Tae |authorlink= |coauthors=Xu Bo, Kastan Michael B |year=2002|month=March |title=Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage |journal=Genes Dev. |volume=16 |issue=5 |pages=560–70 |publisher= |location = United States| issn = 0890-9369| pmid = 11877376 |doi = 10.1101/gad.970602 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=155347 }}</ref><ref name=pmid9789013>{{cite journal |last=Schmiesing |first=J A |authorlink= |coauthors=Ball A R, Gregson H C, Alderton J M, Zhou S, Yokomori K |year=1998|month=October |title=Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=95 |issue=22 |pages=12906–11 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9789013 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.95.22.12906 |pmc=23650 }}</ref><ref name=pmid11590136>{{cite journal |last=Gregson |first=H C |authorlink= |coauthors=Schmiesing J A, Kim J S, Kobayashi T, Zhou S, Yokomori K |year=2001|month=Dec |title=A potential role for human cohesin in mitotic spindle aster assembly |journal=J. Biol. Chem. |volume=276 |issue=50 |pages=47575–82 |publisher= |location = United States| issn = 0021-9258| pmid = 11590136 |doi = 10.1074/jbc.M103364200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==See also==
==See also==

Revision as of 03:44, 30 January 2014

Template:PBB Structural maintenance of chromosomes 3, also known as SMC3, is a human gene.[1] Template:PBB Summary

Model organisms

Model organisms have been used in the study of SMC3 function. A conditional knockout mouse line, called Smc3tm1a(EUCOMM)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty two tests were carried out on mutant mice and six significant abnormalities were observed.[7] No homozygous mutant embryos were identified during gestation, and thus none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice. Females had a higher than normal incidence of pre-wean death in their offspring, and also had a decreased body weight. Males heterozygotes displayed a shortened, upturned snout.[7][14]

Interactions

SMC3 (gene) has been shown to interact with REC8,[15] MXD1,[16] KIFAP3,[17] MXI1[16] and SMC1A.[15][18][19][20]

See also

References

  1. ^ "Entrez Gene: SMC3 structural maintenance of chromosomes 3".
  2. ^ "Body weight data for Smc3". Wellcome Trust Sanger Institute.
  3. ^ "Dysmorphology data for Smc3". Wellcome Trust Sanger Institute.
  4. ^ "DEXA data for Smc3". Wellcome Trust Sanger Institute.
  5. ^ "Salmonella infection data for Smc3". Wellcome Trust Sanger Institute.
  6. ^ "Citrobacter infection data for Smc3". Wellcome Trust Sanger Institute.
  7. ^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  8. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  9. ^ "International Knockout Mouse Consortium".
  10. ^ "Mouse Genome Informatics".
  11. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21677750, please use {{cite journal}} with |pmid=21677750 instead.
  12. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  13. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  14. ^ a b van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  15. ^ a b Lee, Jibak (July 2003). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis". J. Cell. Sci. 116 (Pt 13). England: 2781–90. doi:10.1242/jcs.00495. ISSN 0021-9533. PMID 12759374. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  16. ^ a b Gupta, K (March 1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene. 16 (9). ENGLAND: 1149–59. doi:10.1038/sj.onc.1201634. ISSN 0950-9232. PMID 9528857. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  17. ^ Shimizu, K (March 1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide". J. Biol. Chem. 273 (12). UNITED STATES: 6591–4. doi:10.1074/jbc.273.12.6591. ISSN 0021-9258. PMID 9506951. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  18. ^ Kim, Seong-Tae (2002). "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage". Genes Dev. 16 (5). United States: 560–70. doi:10.1101/gad.970602. ISSN 0890-9369. PMC 155347. PMID 11877376. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  19. ^ Schmiesing, J A (1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proc. Natl. Acad. Sci. U.S.A. 95 (22). UNITED STATES: 12906–11. doi:10.1073/pnas.95.22.12906. ISSN 0027-8424. PMC 23650. PMID 9789013. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  20. ^ Gregson, H C (2001). "A potential role for human cohesin in mitotic spindle aster assembly". J. Biol. Chem. 276 (50). United States: 47575–82. doi:10.1074/jbc.M103364200. ISSN 0021-9258. PMID 11590136. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)

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