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* [[Primary effusion lymphoma]]
* [[Primary effusion lymphoma]]
* [[Lymphomatoid granulomatosis]]
* [[Lymphomatoid granulomatosis]]
* T cell/histiocyte-rich large B-cell lymphoma
* [[T cell/histiocyte-rich large B-cell lymphoma]]
* Primary diffuse large B-cell lymphoma of the CNS (Central Nervous System)
* [[Primary diffuse large B-cell lymphoma of the CNS]] (Central Nervous System)
* Primary cutaneous diffuse large B-cell lymphoma, leg type (Primary cutaneous DLBCL, leg type)
* [[Primary cutaneous diffuse large B-cell lymphoma, leg type]] (Primary cutaneous DLBCL, leg type)
* EBV positive diffuse large B-cell lymphoma of the elderly
* [[EBV positive diffuse large B-cell lymphoma of the elderly]]
* Diffuse large B-cell lymphoma associated with inflammation
* [[Diffuse large B-cell lymphoma associated with inflammation]]
* [[Intravascular large B-cell lymphoma]]
* [[ALK-positive large B-cell lymphoma]]
* [[Plasmablastic lymphoma]]
* [[Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease]]
* [[Primary effusion lymphoma]]
* [[B-cell lymphoma, unclassifiable qith features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma]]
* [[B-cell lymphoma, unclassifiable qith features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma]]


===Other===
===Other===

Revision as of 15:04, 12 March 2014

B-cell lymphoma
SpecialtyOncology Edit this on Wikidata

The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph glands. They develop more frequently in older adults and in immunocompromised individuals.

B-cell lymphomas include both Hodgkin's lymphomas and most non-Hodgkins lymphomas. They are often divided into indolent (slow-growing) lymphomas and aggressive lymphomas. Indolent lymphomas respond rapidly to treatment and are kept under control (in remission) with long-term survival of many years, but are not cured. Aggressive lymphomas usually require intensive treatments, but have good prospects for a permanent cure.[1]

Prognosis and treatment depends on the specific type of lymphoma as well as the stage and grade. Treatment includes radiation and chemotherapy. Early-stage indolent B-cell lymphomas can often be treated with radiation alone, with long-term non-reoccurrence. Early-stage aggressive disease is treated with chemotherapy and often radiation, with a 70-90% cure rate.[1] Late-stage indolent lymphomas are sometimes left untreated and monitored until they progress. Late-stage aggressive disease is treated with chemotherapy, with cure rates of over 70%.[1]

Types

Micrograph showing Hodgkin lymphoma, a type of B cell lymphoma that is usually considered separate from other B cell lymphomas. Field stain.

There are fourteen kinds of lymphomas involving B cells.

Common

Five account for nearly three out of four patients with non-Hodgkin lymphoma:[2]

Rare

The remaining nine are much less common:[2]

Other

Additionally, some researchers separate out lymphomas that appear result from other immune system disorders, such as AIDS-related lymphoma.

Classic Hodgkin's lymphoma and nodular lymphocyte predominant Hodgkin's lymphoma are now considered forms of B-cell lymphoma.[4]

Associated chromosomal translocations

Chromosomal translocations involving the immunoglobulin heavy locus (IGH@) is a classic cytogenetic abnormality for many B-cell lymphomas, including follicular lymphoma, mantle cell lymphoma and Burkitt's lymphoma. In these cases, the immunoglobulin heavy locus forms a fusion protein with another protein that has pro-proliferative or anti-apoptotic abilities. The enhancer element of the immunoglobulin heavy locus, which normally functions to make B cells produce massive production of antibodies, now induces massive transcription of the fusion protein, resulting in excessive pro-proliferative or anti-apoptotic effects on the B cells containing the fusion protein. In Burkitt's lymphoma and mantle cell lymphoma, the other protein in the fusion is c-myc (on chromosome 8) and cyclin D1[5] (on chromosome 11), respectively, which gives the fusion protein pro-proliferative ability. In follicular lymphoma, the fused protein is Bcl-2 (on chromosome 18), which gives the fusion protein anti-apoptotic abilities.

See also

References

  1. ^ a b c Merck Manual home edition, Non-Hodgkin Lymphomas
  2. ^ a b "The Lymphomas" (PDF). The Leukemia & Lymphoma Society. May 2006. p. 12. Retrieved 2008-04-07. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
  3. ^ Mazen Sanoufa, Mohammad Sami Walid, Talat Parveen (2010). "B-Cell Lymphoma of the Thoracic Spine Presenting with Spinal Cord Pressure Syndrome". JOCMR. 2 (1): 53–54. doi:10.4021/jocmr2010.02.258w.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ "HMDS: Hodgkin's Lymphoma". Archived from the original on 4 March 2009. Retrieved 2009-02-01. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  5. ^ Li JY, Gaillard F, Moreau A; et al. (May 1999). "Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescence in situ hybridization". Am. J. Pathol. 154 (5): 1449–52. doi:10.1016/S0002-9440(10)65399-0. PMC 1866594. PMID 10329598. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
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