SYT4: Difference between revisions
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== Pathology == |
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SYT4 is rearranged in [[synovial sarcoma]] with [[SSX1]] or [[SSX2]]. Synovial sarcoma (SS) is characterized by the t(X;18)(p11.2;q11.2) chromosomal translocation detected in >95% of cases. Through this translocation, one of the SYT genes, SYT4 on chromosome 18, is fused to one of the SSX genes on chromosome X. SYT4-SSX1 is the most common fusion subtype, present in approximately two thirds of the cases, followed by SYT4-SSX2 and, very rarely, SYT4-SSX4. Variant fusion transcripts occur less often, and most of the reported cases are the result of small insertions. <ref>{{Cite pmid|19837269}}</ref> |
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==References== |
==References== |
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Revision as of 15:23, 14 March 2014
Template:PBB Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.[1][2]
Pathology
SYT4 is rearranged in synovial sarcoma with SSX1 or SSX2. Synovial sarcoma (SS) is characterized by the t(X;18)(p11.2;q11.2) chromosomal translocation detected in >95% of cases. Through this translocation, one of the SYT genes, SYT4 on chromosome 18, is fused to one of the SSX genes on chromosome X. SYT4-SSX1 is the most common fusion subtype, present in approximately two thirds of the cases, followed by SYT4-SSX2 and, very rarely, SYT4-SSX4. Variant fusion transcripts occur less often, and most of the reported cases are the result of small insertions. [3]
References
- ^ Hilbush BS, Morgan JI (Sep 1994). "A third synaptotagmin gene, Syt3, in the mouse". Proc Natl Acad Sci U S A. 91 (17): 8195–9. doi:10.1073/pnas.91.17.8195. PMC 44572. PMID 8058779.
- ^ "Entrez Gene: SYT4 synaptotagmin IV".
- ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19837269, please use {{cite journal}} with
|pmid=19837269instead.
Further reading
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