User talk:Truebreath

Welcome!

Hello, Truebreath, and welcome to Wikipedia! Thank you for your contributions. I hope you like the place and decide to stay. Here are a few links to pages you might find helpful:

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Dabigatran

I am concerned that some of your additions to dabigatran are extrapolations from monitoring data that do not imply causality. Without stronger sources, one would not want to see this included in a general encyclopedia article. Could you respond to my message on Talk:Dabigatran before making further changes? Thank you. JFW | T@lk 10:05, 3 November 2013 (UTC)

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Disambiguation link notification for November 7

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I have fixed this itemTruebreath (talk) 15:47, 7 November 2013 (UTC)

Welcome to Wikipedia from Wikiproject Medicine!

Welcome to Wikipedia from Wikiproject Medicine! We're a group of interested editors who strive to improve the quality of medical articles here on Wikipedia. One of our members has noticed that you are interested in editing medical articles, and it's great to have a new interested editor on board! In your wiki-travels, a few things that may be relevant to editing wikipedia articles are:

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Feel free to drop a note on my talk page if you have any problems. I wish you all the best on your wikitravels! --LT910001 (talk) 01:27, 11 November 2013 (UTC)

Citation suggestion

Hi. Thanks for your contributions to the Dabigatran article. In case you haven't seen this yet, please check out User:Diberri's Wikipedia template filling tool (instructions). Given a PubMed ID, one can quickly produce a full citation that can be copied and pasted into a Wikipedia article. This tool can save you a lot of work and ensure that the citations are displayed in a consistent manner. Cheers. Boghog (talk) 22:50, 29 November 2013 (UTC)

Source selection

Hello Truebreath, I was wondering if I could draw your attention to an issue that affects your contributions to the NOAC articles. On Wikipedia, health-related articles are governed by a manual of style (which includes guidance on articles about medicines) and a sourcing guideline. You rely quite heavily on primary sources in your additions (e.g. the Bloch et al paper recently added to dabigatran), which effectively contravenes existing guidance. You are trying to write a huge comprehensive review of everything that can be said about these agents; that is not the purpose of an encyclopedia and I worry about introducing information that hasn't been reproduced or verified and may eventually be disproved. There is a risk that I will need to personally remove information that contravenes WP:MEDRS, but I prefer to give you an opportunity to fix this yourself. JFW | T@lk 12:33, 7 March 2014 (UTC)

You've been editing since I left my message. Can you acknowledge that you have received it? JFW | T@lk 22:00, 8 March 2014 (UTC)

I added a review about the woundproblems. I deleted the whole section about cost effectiveness; because most were original studies. I deleted things in dosing. So i am changing the references of original studies to references of secondary sources. --Truebreath (talk) 22:16, 8 March 2014 (UTC)

There are still lots of primary sources in the dabigatran article, such as doi:10.1016/j.amjmed.2013.12.005 (a cohort study). JFW | T@lk 11:06, 9 March 2014 (UTC)

Yes i know, but it confirms the association between dabigatran and myocard infarction in real life. So it is important. Systematic reviews of real life dabigatran events are lacking. We will not see any post approval trial in the near future that will show this.

I looked at the "good wiki article " about warfarin. adverse effects: osteoporosis; look at the extremely poor references. I think you should remove the whole section, because there is no reference to high level secondary source. Only original retrospective and prospective studies. Moreover a systematic review didn't find a relation between warfarin and osteoporosis, but this is not mentioned in the article. " Changes in bone density after exposure to oral anticoagulants: a meta-analysis PJ Caraballo, SE Gabriel, MR Castro… - Osteoporosis …, 1999 -" Look at the purple toe syndrome based on a study with 1 case. Look at the section interactions: almost all references don't come from high level secondary sources. Look at haemorrhages ref 18 is a prospective study; intracranial haemorrhages are lacking...which should be their biggest problem, according the new anticoagulant studies.

I looked at the "good wiki article " about bromazepam: side effects; references 6 to 22 are small trials, primary sources; half of the side effects part has no references.

I looked for "featured articles" about medecines; i didn't find any.

The problem is that harms are not so popular in trials; a systematic review states "in anticoagulant trials there are limited data about harms (exclusive bleedings) " .The harms have to be deducted from post approval, cheaper, phase 4 studies, that are almost always prospective or registry studies, with the good known biases. Maybe we should make a new heading for new potential dangerous medecines: "real world studies" and include all important studies about extern validity (generalisability). I agree that idealiter they should come from systematic reviews. The reason why there were serious doubts about warfarine in older people was the lack of studies about their generalisability. This is important for clinicians and for the patients. Could also Boghog give some input?

--Truebreath (talk) 15:01, 9 March 2014 (UTC)

Guidelines on Wikipedia

Please have a read of WP:MEDMOS. It provides some guidelines on writing style, wording and section headings. Best Doc James (talk · contribs · email) (if I write on your page reply on mine) 23:48, 15 March 2014 (UTC)

Extern validity; generalisability

So i see that all elements of extern validity were removed;"real world experiences""Pharmacovigilance" Cochrane should be disappointed.

So where do i put these things also found in other systematic reviews:

In the literature, reports of excess bleeding with dabigatran in elderly patients with renal dysfunction[40] raise doubts regarding whether the superior safety profile observed with dabigatran in clinical trials will be generalisable to clinical practice.

The findings based on clinical trial populations may not be generalisable to clinical practice where patients tend to be older and have more comorbidities.

Current and New Oral Antithrombotics in Non-valvular Atrial Fibrillation A Network Meta-analysis of 79 808 Patients Ariel Dogliotti, Ernesto Paolasso, Robert P Giugliano http://www.medscape.com/viewarticle/820832_6

--Truebreath (talk) 22:47, 18 March 2014 (UTC)

Probably the best place to bring this up is on the talk page of the article in question. Exactly what content are you hoping to see returned? Doc James (talk · contribs · email) (if I write on your page reply on mine) 23:38, 18 March 2014 (UTC)

This "In the literature, reports of excess bleeding with dabigatran in elderly patients with renal dysfunction[40] raise doubts regarding whether the superior safety profile observed with dabigatran in clinical trials will be generalisable to clinical practice." should go in the section on adverse effects if based on a review. Doc James (talk · contribs · email) (if I write on your page reply on mine) 23:39, 18 March 2014 (UTC)

Thanks

Hello there. I just wanted to thank you for your efforts to contribute to Wikipedia in a way that follows our guidelines. I helped write DVT, for what it's worth, although I could probably use some new oral anticoagulant information. Best wishes. Biosthmors (talk) pls notify me (i.e. {{U}}) while signing a reply, thx 21:06, 19 March 2014 (UTC)

Thanks; i loved yours on DVT to.--Truebreath (talk) 20:29, 7 April 2014 (UTC)

Cite web

Template:Cite web is good for webpages rather than [1]. See Wikipedia:RefToolbar/2.0 of WP:MEDHOW. Best Doc James (talk · contribs · email) (if I write on your page reply on mine) 01:13, 20 March 2014 (UTC)

Legal cases

I am very concerned by this edit. Surely you would not ever open an encyclopedia to find a blatant recruitment message for class action legislation? Please rethink your strategy on how you present this kind of information.

You should also have noticed that your edits still need fixing by other editors. Currently your contributions to the thiazolidinedione articles are being tidied up by someone else. JFW | T@lk 18:36, 30 March 2014 (UTC)

I do my best.--Truebreath (talk) 20:27, 7 April 2014 (UTC)

April 2014

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Oseltamivir

No offense intended on the revert. But I think the CDC and meta analysis authors already considered the funding issue, and for us to add the funding source of the trials as a way of discrediting the research is probably WP:OR. Best Formerly 98 (talk) 23:35, 13 April 2014 (UTC)

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