Teratospermia: Difference between revisions
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<big>الحيوانات المنوية الممسوخة |
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{{-spermia}} |
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'''Teratospermia''' or '''teratozoospermia''' is a condition characterized by the presence of sperm with abnormal morphology that affects fertility in males. |
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==Causes== |
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The causes of teratospermia are unknown in most cases. However, Hodgkin's disease, coeliac disease, and Crohn's disease may contribute in some instances.<ref>http://www.gfmer.ch/Endo/Lectures_09/dupan1.htm</ref> |
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In cases of '''globozoospermia''' (sperm with round heads), the [[Golgi apparatus]] is not transformed into the [[acrosome]] that is needed for [[fertilization]].<ref>Page 155 in: {{cite book |author=Hermann Behre; Eberhard Nieschlag |title=Andrology : Male Reproductive Health and Dysfunction |publisher=Springer |location=Berlin |year=2000 |pages= |isbn=3-540-67224-9 |oclc= |doi= |accessdate=}}</ref> |
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'''Teratozoospermia تيراتو زو سبيرميا |
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''' |
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Teratospermia or teratozoospermia |
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تيراتو زو سبيرميا او تيراتو سبيرميا |
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وتعني (الحيوانات المنوية الممسوخة)ـ |
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هو مرض نادر تتكون فيه الحيوانات المنوية بطريقة مختلفة عن الحيوانات المنوية الطبيعية لدى الرجال مما تؤثر على الخصوبة. |
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<br /> |
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==Symptoms and treatment== |
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<big>'''الأسباب: |
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The presence of abnormally-shaped sperm can negatively affect fertility by reducing sperm motility and/or preventing sperm from adhering to the [[ovum]]. Achieving a pregnancy may be difficult.<ref name="gfmer.ch">http://www.gfmer.ch/Endo/Lectures_09/dupan.htm</ref> |
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</big>''' |
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إلى هذه اللحظة فإن المسببات لهذا المرض مجهولة في معظم الحالات |
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وعلى اية حال, فإن مرض هودجين وهو عبارة عن سرطان يصيب كريات الدم البيضاء, وأمراض الإضطرابات الهضمية |
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وأمراض التهاب الأمعاء كلها قد تؤدي الى مرض (الحيوانات المنوية الممسوخة)ـ |
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أما في حالة |
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globozoospermia |
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على وجه الخصوص |
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وهي الحالة التي تكون فيها رؤوس الحيوانات المنوية مدببة |
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فإنه لا يتم نقل المواد البروتينية اللازمة للإخصاب إلى الكروموسومات من خلال الحيوانات المنوية |
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In testing for teratospermia, sperm are collected and analyzed under a microscope to detect abnormalities. These abnormalities may include heads that are large, small, tapered, or pyriform or tails that are abnormally shaped.<ref>http://www.endotext.org/male/male7/male7_2.htm</ref> |
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<br /> |
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[[Antiestrogen]]s have been shown to be effective in the treatment of teratospermia. <ref name="gfmer.ch"/> |
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Teratozoospermia (including the ''globozoospermia''<ref>{{cite journal |author=Egashira A, Murakami M, Haigo K, Horiuchi T, Kuramoto T |title=A successful pregnancy and live birth after intracytoplasmic sperm injection with globozoospermic sperm and electrical oocyte activation |journal=Fertil. Steril. |volume= 92|issue= 6|pages= 2037.e5–2037.e9|date=September 2009 |pmid=19800059 |doi=10.1016/j.fertnstert.2009.08.013 |url=}}</ref> type), may be treated by [[intracytoplasmic sperm injection]] (ICSI), injecting sperm directly into the egg.<ref name=french>{{cite journal |author=French DB, Sabanegh ES, Goldfarb J, Desai N |title=Does severe teratozoospermia affect blastocyst formation, live birth rate, and other clinical outcome parameters in ICSI cycles? |journal=Fertil Steril |volume=93 |issue=4 |pages=1097–1103 |date=March 2010 |pmid=19200957 |doi=10.1016/j.fertnstert.2008.10.051 |url=}}</ref> Once the egg is fertilized, abnormal sperm morphology does not appear to influence [[blastocyst]] development or blastocyst morphology.<ref name=french/> Even with severe teratozoospermia, microscopy can still detect the few sperm cells that have a "normal" morphology, allowing for optimal success rate.<ref name=french/> |
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==References== |
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<big>'''التشخيص والعلاج |
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<references/> |
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''' |
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</big> |
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إن وجود الحيوانات المنوية بشكل غير طبيعي, يؤثر سلبا على الخصوبة ولهذا تكون تنقل وحركة الحيوانات المنوية غير طبيعية مما يمنعها من الانضمام إلى البويضة. ولهذا فإن تحقيق الحمل قد يكون صعبا. |
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ترجمة |
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عبدالله الجبرتي |
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==See also== |
==See also== |
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Revision as of 21:31, 20 April 2014
 |
| -spermia, Further information: Testicular infertility factors |
| Aspermia—lack of semen; anejaculation |
| Asthenozoospermia—sperm motility below lower reference limit |
| Azoospermia—absence of sperm in the ejaculate |
| Hyperspermia—semen volume above upper reference limit |
| Hypospermia—semen volume below lower reference limit |
| Oligospermia—total sperm count below lower reference limit |
| Necrospermia—absence of living sperm in the ejaculate |
| Teratospermia—fraction of normally formed sperm below lower reference limit |
Teratospermia or teratozoospermia is a condition characterized by the presence of sperm with abnormal morphology that affects fertility in males.
Causes
The causes of teratospermia are unknown in most cases. However, Hodgkin's disease, coeliac disease, and Crohn's disease may contribute in some instances.[1]
In cases of globozoospermia (sperm with round heads), the Golgi apparatus is not transformed into the acrosome that is needed for fertilization.[2]
Symptoms and treatment
The presence of abnormally-shaped sperm can negatively affect fertility by reducing sperm motility and/or preventing sperm from adhering to the ovum. Achieving a pregnancy may be difficult.[3]
In testing for teratospermia, sperm are collected and analyzed under a microscope to detect abnormalities. These abnormalities may include heads that are large, small, tapered, or pyriform or tails that are abnormally shaped.[4]
Antiestrogens have been shown to be effective in the treatment of teratospermia. [3]
Teratozoospermia (including the globozoospermia[5] type), may be treated by intracytoplasmic sperm injection (ICSI), injecting sperm directly into the egg.[6] Once the egg is fertilized, abnormal sperm morphology does not appear to influence blastocyst development or blastocyst morphology.[6] Even with severe teratozoospermia, microscopy can still detect the few sperm cells that have a "normal" morphology, allowing for optimal success rate.[6]
References
- ^ http://www.gfmer.ch/Endo/Lectures_09/dupan1.htm
- ^ Page 155 in: Hermann Behre; Eberhard Nieschlag (2000). Andrology : Male Reproductive Health and Dysfunction. Berlin: Springer. ISBN 3-540-67224-9.
{{cite book}}: CS1 maint: multiple names: authors list (link) - ^ a b http://www.gfmer.ch/Endo/Lectures_09/dupan.htm
- ^ http://www.endotext.org/male/male7/male7_2.htm
- ^ Egashira A, Murakami M, Haigo K, Horiuchi T, Kuramoto T (September 2009). "A successful pregnancy and live birth after intracytoplasmic sperm injection with globozoospermic sperm and electrical oocyte activation". Fertil. Steril. 92 (6): 2037.e5–2037.e9. doi:10.1016/j.fertnstert.2009.08.013. PMID 19800059.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b c French DB, Sabanegh ES, Goldfarb J, Desai N (March 2010). "Does severe teratozoospermia affect blastocyst formation, live birth rate, and other clinical outcome parameters in ICSI cycles?". Fertil Steril. 93 (4): 1097–1103. doi:10.1016/j.fertnstert.2008.10.051. PMID 19200957.
{{cite journal}}: CS1 maint: multiple names: authors list (link)