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{{PBB|geneid=9833}}
{{PBB|geneid=9833}}
'''Maternal embryonic leucine zipper kinase''' is an [[enzyme]] that in humans is encoded by the ''MELK'' [[gene]].<ref name="pmid8724849">{{cite journal | author = Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N | title = Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res | volume = 3 | issue = 1 | pages = 17–24 |date=Nov 1996 | pmid = 8724849 | pmc = | doi =10.1093/dnares/3.1.17 }}</ref><ref name="pmid9136115">{{cite journal | author = Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL | title = New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo | journal = Mol Reprod Dev | volume = 47 | issue = 2 | pages = 148–56 |date=Aug 1997 | pmid = 9136115 | pmc = | doi = 10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MELK maternal embryonic leucine zipper kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9833| accessdate = }}</ref>
'''Maternal embryonic leucine zipper kinase''' is an [[enzyme]] that in humans is encoded by the ''MELK'' [[gene]].<ref name="pmid8724849">{{vcite2 journal | vauthors = Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N | title = Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res | volume = 3 | issue = 1 | pages = 17–24 | date = Nov 1996 | pmid = 8724849 | pmc = | doi = 10.1093/dnares/3.1.17 }}</ref><ref name="pmid9136115">{{vcite2 journal | vauthors = Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL | title = New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo | journal = Mol Reprod Dev | volume = 47 | issue = 2 | pages = 148–56 | date = Aug 1997 | pmid = 9136115 | pmc = | doi = 10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MELK maternal embryonic leucine zipper kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9833| accessdate = }}</ref>


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== Interactions ==
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MELK has been shown to [[Protein-protein interaction|interact]] with [[CDC25B]].<ref name=pmid12400006>{{vcite2 journal | vauthors = Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP | title = Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation | journal = Oncogene | volume = 21 | issue = 50 | pages = 7630–41 | date = Oct 2002 | pmid = 12400006 | doi = 10.1038/sj.onc.1205870 }}</ref>
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==Interactions==
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MELK has been shown to [[Protein-protein interaction|interact]] with [[CDC25B]].<ref name=pmid12400006>{{cite journal |last=Davezac |first=Noélie |authorlink= |author2=Baldin Véronique |author3=Blot Joëlle |author4=Ducommun Bernard |author5=Tassan Jean-Pierre |date=Oct 2002 |title=Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation |journal=Oncogene |volume=21 |issue=50 |pages=7630–41 |publisher= |location = England| issn = 0950-9232| pmid = 12400006 |doi = 10.1038/sj.onc.1205870 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{vcite2 journal | vauthors = Lin ML, Park JH, Nishidate T, Nakamura Y, Katagiri T | title = Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. | journal = Breast Cancer Res. | volume = 9 | issue = 1 | pages = R17 | year = 2007 | pmid = 17280616 | pmc = 1851384 | doi = 10.1186/bcr1650 }}
{{PBB_Further_reading
* {{vcite2 journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
| citations =
*{{cite journal | author=Lin ML, Park JH, Nishidate T, et al. |title=Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. |journal=Breast Cancer Res. |volume=9 |issue= 1 |pages= R17 |year= 2007 |pmid= 17280616 |doi= 10.1186/bcr1650 | pmc=1851384 }}
* {{vcite2 journal | vauthors = Beullens M, Vancauwenbergh S, Morrice N, Derua R, Ceulemans H, Waelkens E, Bollen M | title = Substrate specificity and activity regulation of protein kinase MELK. | journal = J. Biol. Chem. | volume = 280 | issue = 48 | pages = 40003–11 | year = 2006 | pmid = 16216881 | doi = 10.1074/jbc.M507274200 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, et al. |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
* {{vcite2 journal | vauthors = Vulsteke V, Beullens M, Boudrez A, Keppens S, Van Eynde A, Rider MH, Stalmans W, Bollen M | title = Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. | journal = J. Biol. Chem. | volume = 279 | issue = 10 | pages = 8642–7 | year = 2004 | pmid = 14699119 | doi = 10.1074/jbc.M311466200 }}
*{{cite journal | author=Beullens M, Vancauwenbergh S, Morrice N, et al. |title=Substrate specificity and activity regulation of protein kinase MELK. |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 40003–11 |year= 2006 |pmid= 16216881 |doi= 10.1074/jbc.M507274200 }}
* {{vcite2 journal | vauthors = Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP | title = Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. | journal = Oncogene | volume = 21 | issue = 50 | pages = 7630–41 | year = 2002 | pmid = 12400006 | doi = 10.1038/sj.onc.1205870 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, et al. |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
* {{vcite2 journal | vauthors = Seong HA, Gil M, Kim KT, Kim SJ, Ha H | title = Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). | journal = Biochem. J. | volume = 361 | issue = Pt 3 | pages = 597–604 | year = 2002 | pmid = 11802789 | pmc = 1222342 | doi = 10.1042/0264-6021:3610597 }}
*{{cite journal | author=Vulsteke V, Beullens M, Boudrez A, et al. |title=Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 8642–7 |year= 2004 |pmid= 14699119 |doi= 10.1074/jbc.M311466200 }}
* {{vcite2 journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, et al. |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
* {{vcite2 journal | vauthors = Gil M, Yang Y, Lee Y, Choi I, Ha H | title = Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells | journal = Gene | volume = 195 | issue = 2 | pages = 295–301 | year = 1997 | pmid = 9305775 | doi = 10.1016/S0378-1119(97)00181-9 }}
*{{cite journal | author=Davezac N, Baldin V, Blot J, et al. |title=Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. |journal=Oncogene |volume=21 |issue= 50 |pages= 7630–41 |year= 2002 |pmid= 12400006 |doi= 10.1038/sj.onc.1205870 }}
* {{vcite2 journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Seong HA, Gil M, Kim KT, et al. |title=Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 597–604 |year= 2002 |pmid= 11802789 |doi=10.1042/0264-6021:3610597 | pmc=1222342 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Gil M, Yang Y, Lee Y, et al. |title=Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells |journal=Gene |volume=195 |issue= 2 |pages= 295–301 |year= 1997 |pmid= 9305775 |doi=10.1016/S0378-1119(97)00181-9 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
}}
{{refend}}
{{refend}}


{{Serine/threonine-specific protein kinases}}
{{Serine/threonine-specific protein kinases}}

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{{gene-9-stub}}
{{gene-9-stub}}

Revision as of 15:29, 6 January 2015

Template:PBB Maternal embryonic leucine zipper kinase is an enzyme that in humans is encoded by the MELK gene.[1][2][3]

Interactions

MELK has been shown to interact with CDC25B.[4]

References

  1. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  2. ^ Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL (Aug 1997). "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Mol Reprod Dev. 47 (2): 148–56. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.
  3. ^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase".
  4. ^ Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP (Oct 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. PMID 12400006.

Further reading

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