Linopirdine: Difference between revisions
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==Synthesis== |
==Synthesis== |
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[[File:Linopirdine synthesis.png|thumb|center|700px|Linopirdine synthesis:<ref>{{Cite doi|10.1080/00397919308011258}}</ref>]] |
[[File:Linopirdine synthesis.png|thumb|center|700px|Linopirdine synthesis:<ref>{{Cite doi|10.1080/00397919308011258}}</ref>]] |
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The synthesis starts with a standard scheme for preparing indoxyls. Thus, acylation of [[diphenylamine]] with [[oxalyl chloride]] leads to the amide. The acid chloride then cyclizes into the ring on heating to afford (). Reaction of that product with [[4-picoline]] under [[phase-transfer catalysis|phase-transfer]] conditions catalyzed by a [[quaternary salt]] affords the carbinol (). |
The synthesis starts with a standard scheme for preparing indoxyls. Thus, acylation of [[diphenylamine]] with [[oxalyl chloride]] leads to the amide. The acid chloride then cyclizes into the ring on heating to afford (). Reaction of that product with [[4-picoline]] under [[phase-transfer catalysis|phase-transfer]] conditions catalyzed by a [[quaternary salt]] affords the carbinol () from addition of the transient anion on the methyl group of the [[picoline]] to the more [[electrophilic]] carbonyl group. |
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==See also== |
==See also== |
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Revision as of 23:02, 25 January 2015
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| Formula | C26H21N3O |
| Molar mass | 391.465 g/mol g·mol−1 |
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Linopirdine is a putative cognition-enhancing drug with a novel mechanism of action. Linopirdine blocks the KCNQ2\3 heteromer M current with an IC50 of 2.4nM[1] disinhibiting acetylcholine release, and increasing hippocampal CA3-schaffer collateral mediated glutamate release onto CA1 pyramidal neurons.[2] In a murine model linopirdine is able to nearly completely reverse the senescence-related decline in cortical c-FOS, an effect which is blocked by atropine and MK-801, suggesting Linopirdine can compensate for the age related decline in acetylcholine release.[3] Linopirdine also blocks homomeric KCNQ1 and KCNQ4 voltage gated potassium channels which contribute to vascular tone with substantially less selectivity than KCNQ2/3.[1]
Synthesis
The synthesis starts with a standard scheme for preparing indoxyls. Thus, acylation of diphenylamine with oxalyl chloride leads to the amide. The acid chloride then cyclizes into the ring on heating to afford (). Reaction of that product with 4-picoline under phase-transfer conditions catalyzed by a quaternary salt affords the carbinol () from addition of the transient anion on the methyl group of the picoline to the more electrophilic carbonyl group.
See also
References
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|pmid=22674722instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11378256, please use {{cite journal}} with
|pmid=11378256instead. - ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1080/00397919308011258, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with
|doi=10.1080/00397919308011258instead.
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