Linopirdine: Difference between revisions

Linopirdine
Clinical data
ATC code	N06BX09 (WHO) ;
Identifiers
	IUPAC name 1-phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one;
CAS Number	105431-72-9 ;
PubChem CID	3932;
IUPHAR/BPS	2599;
ChemSpider	3795 ;
UNII	I5TB3NZ94T;
KEGG	D04741 ;
ChEMBL	ChEMBL319111 ;
CompTox Dashboard (EPA)	DTXSID6045163 ;
Chemical and physical data
Formula	C26H21N3O
Molar mass	391.465 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N(c1ccccc1C2(Cc3ccncc3)Cc4ccncc4)c5ccccc5;
	InChI InChI=1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2 ; Key:YEJCDKJIEMIWRQ-UHFFFAOYSA-N ;
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Revision as of 08:02, 26 January 2015

Linopirdine is a putative cognition-enhancing drug with a novel mechanism of action. Linopirdine blocks the KCNQ2\3 heteromer M current with an IC50 of 2.4nM^[1] disinhibiting acetylcholine release, and increasing hippocampal CA3-schaffer collateral mediated glutamate release onto CA1 pyramidal neurons.^[2] In a murine model linopirdine is able to nearly completely reverse the senescence-related decline in cortical c-FOS, an effect which is blocked by atropine and MK-801, suggesting Linopirdine can compensate for the age related decline in acetylcholine release.^[3] Linopirdine also blocks homomeric KCNQ1 and KCNQ4 voltage gated potassium channels which contribute to vascular tone with substantially less selectivity than KCNQ2/3.^[1]

Synthesis

The synthesis starts with a standard scheme for preparing indoxyls. Thus, acylation of diphenylamine with oxalyl chloride leads to the amide. The acid chloride then cyclizes into the ring on heating to afford (). Reaction of that product with 4-picoline under phase-transfer conditions catalyzed by a quaternary salt affords the carbinol () from addition of the transient anion on the methyl group of the picoline to the more electrophilic carbonyl group. The alcohol is then dehydrated by means of acetic anhydride and the resulting olefin hydrogenated to afford the indolone (). The 3 position is now activated by the adjacent benzene ring on one side and the carbonyl group on the other. Alkylation with α-chloropicoline proceeds with hydroxide as the base to afford Linopirdine.

References

^ ^a ^b Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 9694925, please use {{cite journal}} with |pmid=9694925 instead.
^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22674722, please use {{cite journal}} with |pmid=22674722 instead.
^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11378256, please use {{cite journal}} with |pmid=11378256 instead.
^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1080/00397919308011258, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1080/00397919308011258 instead.

Template:Nootropics

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[pmid9694925-1] Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 9694925, please use {{cite journal}} with |pmid=9694925 instead.

[pmid22674722-2] Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22674722, please use {{cite journal}} with |pmid=22674722 instead.

[pmid11378256-3] Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11378256, please use {{cite journal}} with |pmid=11378256 instead.

[4] Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1080/00397919308011258, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1080/00397919308011258 instead.

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-{{Underlinked|date=October 2013}}
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 '''Linopirdine''' is a putative cognition-enhancing drug with a novel mechanism of action.  Linopirdine blocks the KCNQ2\3 heteromer M current with an IC50 of 2.4nM<ref name="pmid9694925">{{Cite pmid|9694925}}</ref> disinhibiting acetylcholine release, and increasing hippocampal CA3-schaffer collateral mediated glutamate release onto CA1 pyramidal neurons.<ref name="pmid22674722">{{Cite pmid|22674722}}</ref>  In a murine model linopirdine is able to nearly completely reverse the senescence-related decline in cortical c-FOS, an effect which is blocked by atropine and MK-801, suggesting Linopirdine can compensate for the age related decline in acetylcholine release.<ref name="pmid11378256">{{Cite pmid|11378256}}</ref>  Linopirdine also blocks homomeric KCNQ1 and KCNQ4 voltage gated potassium channels which contribute to vascular tone with substantially less selectivity than KCNQ2/3.<ref name="pmid9694925">{{Cite pmid|9694925}}</ref>
 ==Synthesis==
 [[File:Linopirdine synthesis.png|thumb|center|700px|Linopirdine synthesis:<ref>{{Cite doi|10.1080/00397919308011258}}</ref>]]
-The synthesis starts with a standard scheme for preparing indoxyls. Thus, acylation of [[diphenylamine]] with [[oxalyl chloride]] leads to the amide. The acid chloride then cyclizes into the ring on heating to afford (). Reaction of that product with [[4-picoline]] under [[phase-transfer catalysis|phase-transfer]] conditions catalyzed by a [[quaternary salt]] affords the carbinol () from addition of the transient anion on the methyl group of the [[picoline]] to the more [[electrophilic]] carbonyl group. The alcohol is then dehydrated by means of [[acetic anhydride]] and the resulting olefin hydrogenated to afford the [[indolone]] (). The 3 position is now activated by the adjacent benzene ring on one side and the carbonyl group on the other. Alkylation with α-chloropicoline proceeds with hydroxide as the base to afford [[Linopirdine]].
+The synthesis starts with a standard scheme for preparing indoxyls. Thus, acylation of [[diphenylamine]] with [[oxalyl chloride]] leads to the amide. The acid chloride then cyclizes into the ring on heating to afford (). Reaction of that product with [[4-picoline]] under [[phase-transfer catalysis|phase-transfer]] conditions catalyzed by a [[quaternary salt]] affords the carbinol () from addition of the transient anion on the methyl group of the [[picoline]] to the more [[electrophilic]] carbonyl group. The alcohol is then dehydrated by means of [[acetic anhydride]] and the resulting olefin hydrogenated to afford the [[indolone]] (). The 3 position is now activated by the adjacent benzene ring on one side and the carbonyl group on the other. Alkylation with α-chloropicoline proceeds with hydroxide as the base to afford Linopirdine.
 ==See also==
@@ Line 66: / Line 66: @@
 ==References==
 {{Reflist}}
 {{Nootropics}}