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'''5-Methoxy-2-aminoindane''' ('''MEAI''', also known as '''5-MeO-AI'''), also called '''Chaperon''', is a psychoactive small molecule belonging to the aminoindanes with a mechanism of action described by one patent as Dopamine D3 receptor ligands.<ref>{{cite web|last1=Haadsma-Svensson|first1=Susanne|title=2-aminoindans as selective dopamine D3 ligands|url=http://www.google.com/patents/US5708018}}</ref> From a substance abuse treatment point of view it may fall into Fred Von Steiff, M.D.'s back-door method to treatment of alcoholism<ref>{{cite web|last1=Duke|first1=Michael|title=Very Easily Understood Breakdown of an Intricate Subject|url=http://www.amazon.ca/Understanding-Genetics-Neurochemistry-Addiction-Sobriety-ebook/dp/B006WGS4TK|publisher=Amazon Book Reviews|accessdate=28 January 2015}}</ref> described in his book "Brain in Balance".<ref>Brain in Balance: Understanding the Genetics and Neurochemistry Behind Addiction and Sobriety ISBN 978-1475045673</ref>. And further supported and elaborated in rat studies<ref>{{cite journal|last1=Weiss|first1=Friedbert|last2=Parsons|first2=Loren|last3=Schulteis|first3=Gery|last4=Hyytia|first4=Petri|last5=Lorang|first5=Marge|last6=Bloom|first6=Floyd|last7=Koob|first7=George|title=Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5Hydroxytryptamine Release in Dependent Rats|journal=The Journal of Neuroscience,|date=may 15 1996|volume=16|issue=10|pages=3474-3485|accessdate=6 February 2015}}</ref>.
'''5-Methoxy-2-aminoindane''' ('''MEAI''', also known as '''5-MeO-AI'''), also called '''Chaperon''', is a psychoactive small molecule belonging to the aminoindanes with a mechanism of action described by one patent as Dopamine D3 receptor ligands.<ref>{{cite web|last1=Haadsma-Svensson|first1=Susanne|title=2-aminoindans as selective dopamine D3 ligands|url=http://www.google.com/patents/US5708018}}</ref> From a substance abuse treatment point of view it may fall into Fred Von Steiff, M.D.'s back-door method to treatment of alcoholism<ref>{{cite web|last1=Duke|first1=Michael|title=Very Easily Understood Breakdown of an Intricate Subject|url=http://www.amazon.ca/Understanding-Genetics-Neurochemistry-Addiction-Sobriety-ebook/dp/B006WGS4TK|publisher=Amazon Book Reviews|accessdate=28 January 2015}}</ref> described in his book "Brain in Balance".<ref>Brain in Balance: Understanding the Genetics and Neurochemistry Behind Addiction and Sobriety ISBN 978-1475045673</ref>. And further supported and elaborated in rat studies<ref>{{cite journal|last1=Weiss|first1=Friedbert|last2=Parsons|first2=Loren|last3=Schulteis|first3=Gery|last4=Hyytia|first4=Petri|last5=Lorang|first5=Marge|last6=Bloom|first6=Floyd|last7=Koob|first7=George|title=Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5Hydroxytryptamine Release in Dependent Rats|journal=The Journal of Neuroscience,|date=15 May 1996|volume=16|issue=10|pages=3474-3485|accessdate=6 February 2015}}</ref>.


It was first prepared by [[Schering AG]] in 1956.<ref>[http://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=19561115&CC=DE&NR=952441C&KC=C Verfahren zur Herstellung von analgetisch wirksamen 2-Aminoindanverbindungen], German Patent DE952441, Nov. 15, 1956</ref> [[David Nutt]] and [[Amanda Feilding]] filed a patent application for the drug that is supposed to give people a pleasant intoxication as well as limit the amount they drink.<ref>{{cite web | url=http://www.newscientist.com/article/mg22530022.900 | title=High and dry? Party drug could target excess drinking | publisher=New Scientist | date=31 December 2014 | accessdate=31 December 2014 | author=Michael Slezak}}</ref><ref>{{cite web|last1=Gray|first1=Richard|title=Could a legal high that mimics ecstasy stop people from boozing? Party drug is patented for use as ‘binge mitigation agent’|url=http://www.dailymail.co.uk/sciencetech/article-2892366/Legal-high-mimics-ecstasy-help-stop-people-boozing-Party-drug-patented-use-binge-mitigation-agent.html|publisher=Daily Mail|accessdate=19 January 2015}}</ref><ref>{{cite web|last1=Theresa|first1=Fisher|title=Doctors Have Discovered the Simplest Way to Quit Drinking — By Doing Drugs|url=http://mic.com/articles/108052/why-one-u-k-doctor-wants-you-to-take-a-party-drug-for-your-health|accessdate=19 January 2015}}</ref>
It was first prepared by [[Schering AG]] in 1956.<ref>[http://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=19561115&CC=DE&NR=952441C&KC=C Verfahren zur Herstellung von analgetisch wirksamen 2-Aminoindanverbindungen], German Patent DE952441, Nov. 15, 1956</ref> [[David Nutt]] and [[Amanda Feilding]] filed a patent application for the drug that is supposed to give people a pleasant intoxication as well as limit the amount they drink.<ref>{{cite web | url=http://www.newscientist.com/article/mg22530022.900 | title=High and dry? Party drug could target excess drinking | publisher=New Scientist | date=31 December 2014 | accessdate=31 December 2014 | author=Michael Slezak}}</ref><ref>{{cite web|last1=Gray|first1=Richard|title=Could a legal high that mimics ecstasy stop people from boozing? Party drug is patented for use as ‘binge mitigation agent’|url=http://www.dailymail.co.uk/sciencetech/article-2892366/Legal-high-mimics-ecstasy-help-stop-people-boozing-Party-drug-patented-use-binge-mitigation-agent.html|publisher=Daily Mail|accessdate=19 January 2015}}</ref><ref>{{cite web|last1=Theresa|first1=Fisher|title=Doctors Have Discovered the Simplest Way to Quit Drinking — By Doing Drugs|url=http://mic.com/articles/108052/why-one-u-k-doctor-wants-you-to-take-a-party-drug-for-your-health|accessdate=19 January 2015}}</ref>

Revision as of 05:12, 6 February 2015

MEAI
Clinical data
Other names5-Methoxy-2-aminoindane; 2,3-Dihydro-5-methoxy-1H-inden-2-amine; MEAI; 5-MeO-AI; Chaperon
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • undergoing safety testing
Identifiers
  • 5-Methoxy-2-indanamine
CAS Number
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H13NO
Molar mass163.216 g/mol g·mol−1
 ☒NcheckY (what is this?)  (verify)

5-Methoxy-2-aminoindane (MEAI, also known as 5-MeO-AI), also called Chaperon, is a psychoactive small molecule belonging to the aminoindanes with a mechanism of action described by one patent as Dopamine D3 receptor ligands.[1] From a substance abuse treatment point of view it may fall into Fred Von Steiff, M.D.'s back-door method to treatment of alcoholism[2] described in his book "Brain in Balance".[3]. And further supported and elaborated in rat studies[4].

It was first prepared by Schering AG in 1956.[5] David Nutt and Amanda Feilding filed a patent application for the drug that is supposed to give people a pleasant intoxication as well as limit the amount they drink.[6][7][8]

MEAI was available through grey market sources in 2011.[9] At least 2 journalists tried it on themselves and reported to the public: Michael Slezak from New Scientist[10] and Brie Traits from BBC3.[11] Apparently, Nutt has also tried it himself.[12]

The idea of alcohol substitution got public attention 1 year prior to the announcement of chaperon[13] but apparently, chaperon innovates in that it can be consumed together with alcohol without ill effect.[14]

See also

A review of alcohol replacements[15]

References

  1. ^ Haadsma-Svensson, Susanne. "2-aminoindans as selective dopamine D3 ligands".
  2. ^ Duke, Michael. "Very Easily Understood Breakdown of an Intricate Subject". Amazon Book Reviews. Retrieved 28 January 2015.
  3. ^ Brain in Balance: Understanding the Genetics and Neurochemistry Behind Addiction and Sobriety ISBN 978-1475045673
  4. ^ Weiss, Friedbert; Parsons, Loren; Schulteis, Gery; Hyytia, Petri; Lorang, Marge; Bloom, Floyd; Koob, George (15 May 1996). "Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5Hydroxytryptamine Release in Dependent Rats". The Journal of Neuroscience,. 16 (10): 3474–3485. {{cite journal}}: |access-date= requires |url= (help)CS1 maint: extra punctuation (link)
  5. ^ Verfahren zur Herstellung von analgetisch wirksamen 2-Aminoindanverbindungen, German Patent DE952441, Nov. 15, 1956
  6. ^ Michael Slezak (31 December 2014). "High and dry? Party drug could target excess drinking". New Scientist. Retrieved 31 December 2014.
  7. ^ Gray, Richard. "Could a legal high that mimics ecstasy stop people from boozing? Party drug is patented for use as 'binge mitigation agent'". Daily Mail. Retrieved 19 January 2015.
  8. ^ Theresa, Fisher. "Doctors Have Discovered the Simplest Way to Quit Drinking — By Doing Drugs". Retrieved 19 January 2015.
  9. ^ "5-Meo-AI". Retrieved 31 December 2014.
  10. ^ Slezak, Michael. "A test of chaperon".
  11. ^ Traits, Brie. "How Safe Are My Drugs?". BBC. BBC3.
  12. ^ Phillipa, Skett. "Care for a legal high that's "Chaperon-ed by Imperial"?". Felix Online.
  13. ^ Nutt, David. "Alcohol without the hangover? It's closer than you think". The Guardian.
  14. ^ Cormier, Zoe. "Pop a 'sober up' pill or guzzle synthetic booze to avoid hangovers". The Daily Telegraph. Retrieved 20 January 2015.
  15. ^ Tsao, Tim. "A Drug That Makes You Drink Less Alcohol". YouTube. Retrieved 20 January 2015.
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