ABCC5: Difference between revisions

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Template:PBB Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene.^[1]^[2]^[3]

Template:PBB Summary

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD (Dec 1998). "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". J Natl Cancer Inst. 90 (22): 1735–41. doi:10.1093/jnci/90.22.1735. PMID 9827529.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ "Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5".

External links

ABCC5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ABCC5 human gene location in the UCSC Genome Browser.
ABCC5 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Template:PBB Controls

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[WikiPathways-4] The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

[pmid8894702-1] Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid9827529-2] Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD (Dec 1998). "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". J Natl Cancer Inst. 90 (22): 1735–41. doi:10.1093/jnci/90.22.1735. PMID 9827529.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[entrez-3] "Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5".

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 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Kool M |title=Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines |journal=Cancer Res. |volume=57 |issue= 16 |pages= 3537–47 |year= 1997 |pmid= 9270026 |doi=  | author-separator=,  | author2=de Haas M  | author3=Scheffer GL  | display-authors=3  | last4=Scheper  | first4=RJ  | last5=Van Eijk  | first5=MJ  | last6=Juijn  | first6=JA  | last7=Baas  | first7=F  | last8=Borst  | first8=P  }}
+*{{cite journal  | author=Kool M |title=Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines |journal=Cancer Res. |volume=57 |issue= 16 |pages= 3537–47 |year= 1997 |pmid= 9270026 |doi=  | name-list-format=vanc | author2=de Haas M  | author3=Scheffer GL  | display-authors=3  | last4=Scheper  | first4=RJ  | last5=Van Eijk  | first5=MJ  | last6=Juijn  | first6=JA  | last7=Baas  | first7=F  | last8=Borst  | first8=P  }}
-*{{cite journal  | author=Suzuki T |title=cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 3 |pages= 790–4 |year= 1997 |pmid= 9325169 |doi= 10.1006/bbrc.1997.7346  | author-separator=,  | author2=Nishio K  | author3=Sasaki H  | display-authors=3  | last4=Kurokawa  | first4=Hirokazu  | last5=Saito-Ohara  | first5=Fumiko  | last6=Ikeuchi  | first6=Tatsuro  | last7=Tanabe  | first7=Shinzo  | last8=Terada  | first8=Masaaki  | last9=Saijo  | first9=Nagahiro }}
+*{{cite journal  | author=Suzuki T |title=cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 3 |pages= 790–4 |year= 1997 |pmid= 9325169 |doi= 10.1006/bbrc.1997.7346  | name-list-format=vanc | author2=Nishio K  | author3=Sasaki H  | display-authors=3  | last4=Kurokawa  | first4=Hirokazu  | last5=Saito-Ohara  | first5=Fumiko  | last6=Ikeuchi  | first6=Tatsuro  | last7=Tanabe  | first7=Shinzo  | last8=Terada  | first8=Masaaki  | last9=Saijo  | first9=Nagahiro }}
 *{{cite journal  | author=Cole SP |title=Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins |journal=J. Natl. Cancer Inst. |volume=91 |issue= 10 |pages= 888–9 |year= 1999 |pmid= 10340910 |doi=10.1093/jnci/91.10.888  }}
 *{{cite journal  | author=McAleer MA, Breen MA, White NL, Matthews N |title=pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23541–8 |year= 1999 |pmid= 10438534 |doi=10.1074/jbc.274.33.23541  }}
-*{{cite journal  | author=Suzuki T |title=Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts |journal=Gene |volume=242 |issue= 1–2 |pages= 167–73 |year= 2000 |pmid= 10721709 |doi=10.1016/S0378-1119(99)00529-6  | author-separator=,  | author2=Sasaki H  | author3=Kuh HJ  | display-authors=3  | last4=Agui  | first4=Mika  | last5=Tatsumi  | first5=Yasuaki  | last6=Tanabe  | first6=Shinzo  | last7=Terada  | first7=Masaaki  | last8=Saijo  | first8=Nagahiro  | last9=Nishio  | first9=Kazuto  }}
+*{{cite journal  | author=Suzuki T |title=Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts |journal=Gene |volume=242 |issue= 1–2 |pages= 167–73 |year= 2000 |pmid= 10721709 |doi=10.1016/S0378-1119(99)00529-6  | name-list-format=vanc | author2=Sasaki H  | author3=Kuh HJ  | display-authors=3  | last4=Agui  | first4=Mika  | last5=Tatsumi  | first5=Yasuaki  | last6=Tanabe  | first6=Shinzo  | last7=Terada  | first7=Masaaki  | last8=Saijo  | first8=Nagahiro  | last9=Nishio  | first9=Kazuto  }}
-*{{cite journal  | author=Oguri T |title=Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer |journal=Int. J. Cancer |volume=86 |issue= 1 |pages= 95–100 |year= 2000 |pmid= 10728601 |doi=10.1002/(SICI)1097-0215(20000401)86:1<95::AID-IJC15>3.0.CO;2-G  | author-separator=,  | author2=Isobe T  | author3=Suzuki T  | display-authors=3  | last4=Nishio  | first4=Kazuto  | last5=Fujiwara  | first5=Yasuhiro  | last6=Katoh  | first6=Osamu  | last7=Yamakido  | first7=Michio  }}
+*{{cite journal  | author=Oguri T |title=Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer |journal=Int. J. Cancer |volume=86 |issue= 1 |pages= 95–100 |year= 2000 |pmid= 10728601 |doi=10.1002/(SICI)1097-0215(20000401)86:1<95::AID-IJC15>3.0.CO;2-G  | name-list-format=vanc | author2=Isobe T  | author3=Suzuki T  | display-authors=3  | last4=Nishio  | first4=Kazuto  | last5=Fujiwara  | first5=Yasuhiro  | last6=Katoh  | first6=Osamu  | last7=Yamakido  | first7=Michio  }}
-*{{cite journal  | author=Dias Neto E |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267  | author-separator=,  | author2=Correa RG  | author3=Verjovski-Almeida S  | display-authors=3  | last4=Briones  | first4=MR  | last5=Nagai  | first5=MA  | last6=Da Silva Jr  | first6=W  | last7=Zago  | first7=MA  | last8=Bordin  | first8=S  | last9=Costa  | first9=FF  }}
+*{{cite journal  | author=Dias Neto E |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267  | name-list-format=vanc | author2=Correa RG  | author3=Verjovski-Almeida S  | display-authors=3  | last4=Briones  | first4=MR  | last5=Nagai  | first5=MA  | last6=Da Silva Jr  | first6=W  | last7=Zago  | first7=MA  | last8=Bordin  | first8=S  | last9=Costa  | first9=FF  }}
-*{{cite journal  | author=Wijnholds J |title=Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7476–81 |year= 2000 |pmid= 10840050 |doi= 10.1073/pnas.120159197  | pmc=16570  | author-separator=,  | author2=Mol CA  | author3=van Deemter L  | display-authors=3  | last4=De Haas  | first4=M  | last5=Scheffer  | first5=GL  | last6=Baas  | first6=F  | last7=Beijnen  | first7=JH  | last8=Scheper  | first8=RJ  | last9=Hatse  | first9=S }}
+*{{cite journal  | author=Wijnholds J |title=Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7476–81 |year= 2000 |pmid= 10840050 |doi= 10.1073/pnas.120159197  | pmc=16570  | name-list-format=vanc | author2=Mol CA  | author3=van Deemter L  | display-authors=3  | last4=De Haas  | first4=M  | last5=Scheffer  | first5=GL  | last6=Baas  | first6=F  | last7=Beijnen  | first7=JH  | last8=Scheper  | first8=RJ  | last9=Hatse  | first9=S }}
 *{{cite journal  | author=Jedlitschky G, Burchell B, Keppler D |title=The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30069–74 |year= 2000 |pmid= 10893247 |doi= 10.1074/jbc.M005463200 }}
 *{{cite journal  | author=Alcorn J, Lu X, Moscow JA, McNamara PJ |title=Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction |journal=J. Pharmacol. Exp. Ther. |volume=303 |issue= 2 |pages= 487–96 |year= 2002 |pmid= 12388627 |doi= 10.1124/jpet.102.038315 }}
-*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  | author-separator=,  | author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  | name-list-format=vanc | author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
-*{{cite journal  | author=Wielinga PR |title=Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17664–71 |year= 2003 |pmid= 12637526 |doi= 10.1074/jbc.M212723200  | author-separator=,  | author2=van der Heijden I  | author3=Reid G  | display-authors=3  | last4=Beijnen  | first4=JH  | last5=Wijnholds  | first5=J  | last6=Borst  | first6=P }}
+*{{cite journal  | author=Wielinga PR |title=Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17664–71 |year= 2003 |pmid= 12637526 |doi= 10.1074/jbc.M212723200  | name-list-format=vanc | author2=van der Heijden I  | author3=Reid G  | display-authors=3  | last4=Beijnen  | first4=JH  | last5=Wijnholds  | first5=J  | last6=Borst  | first6=P }}
-*{{cite journal  | author=Pascolo L |title=Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 1 |pages= 259–65 |year= 2003 |pmid= 12646196 |doi=10.1016/S0006-291X(03)00327-9  | author-separator=,  | author2=Fernetti C  | author3=Pirulli D  | display-authors=3  | last4=Crovella  | first4=Sergio  | last5=Amoroso  | first5=Antonio  | last6=Tiribelli  | first6=Claudio  }}
+*{{cite journal  | author=Pascolo L |title=Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 1 |pages= 259–65 |year= 2003 |pmid= 12646196 |doi=10.1016/S0006-291X(03)00327-9  | name-list-format=vanc | author2=Fernetti C  | author3=Pirulli D  | display-authors=3  | last4=Crovella  | first4=Sergio  | last5=Amoroso  | first5=Antonio  | last6=Tiribelli  | first6=Claudio  }}
-*{{cite journal  | author=Reid G |title=Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5 |journal=Mol. Pharmacol. |volume=63 |issue= 5 |pages= 1094–103 |year= 2003 |pmid= 12695538 |doi=10.1124/mol.63.5.1094  | author-separator=,  | author2=Wielinga P  | author3=Zelcer N  | display-authors=3  | last4=De Haas  | first4=M  | last5=Van Deemter  | first5=L  | last6=Wijnholds  | first6=J  | last7=Balzarini  | first7=J  | last8=Borst  | first8=P  }}
+*{{cite journal  | author=Reid G |title=Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5 |journal=Mol. Pharmacol. |volume=63 |issue= 5 |pages= 1094–103 |year= 2003 |pmid= 12695538 |doi=10.1124/mol.63.5.1094  | name-list-format=vanc | author2=Wielinga P  | author3=Zelcer N  | display-authors=3  | last4=De Haas  | first4=M  | last5=Van Deemter  | first5=L  | last6=Wijnholds  | first6=J  | last7=Balzarini  | first7=J  | last8=Borst  | first8=P  }}
-*{{cite journal  | author=Dazert P |title=Expression and Localization of the Multidrug Resistance Protein 5 (MRP5/ABCC5), a Cellular Export Pump for Cyclic Nucleotides, in Human Heart |journal=Am. J. Pathol. |volume=163 |issue= 4 |pages= 1567–77 |year= 2003 |pmid= 14507663 |doi=  10.1016/S0002-9440(10)63513-4| pmc=1868287  | author-separator=,  | author2=Meissner K  | author3=Vogelgesang S  | display-authors=3  | last4=Heydrich  | first4=B  | last5=Eckel  | first5=L  | last6=Böhm  | first6=M  | last7=Warzok  | first7=R  | last8=Kerb  | first8=R  | last9=Brinkmann  | first9=U  }}
+*{{cite journal  | author=Dazert P |title=Expression and Localization of the Multidrug Resistance Protein 5 (MRP5/ABCC5), a Cellular Export Pump for Cyclic Nucleotides, in Human Heart |journal=Am. J. Pathol. |volume=163 |issue= 4 |pages= 1567–77 |year= 2003 |pmid= 14507663 |doi=  10.1016/S0002-9440(10)63513-4| pmc=1868287  | name-list-format=vanc | author2=Meissner K  | author3=Vogelgesang S  | display-authors=3  | last4=Heydrich  | first4=B  | last5=Eckel  | first5=L  | last6=Böhm  | first6=M  | last7=Warzok  | first7=R  | last8=Kerb  | first8=R  | last9=Brinkmann  | first9=U  }}
-*{{cite journal  | author=Brandenberger R |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971  | author-separator=,  | author2=Wei H  | author3=Zhang S  | display-authors=3  | last4=Lei  | first4=Shirley  | last5=Murage  | first5=Jaji  | last6=Fisk  | first6=Gregory J  | last7=Li  | first7=Yan  | last8=Xu  | first8=Chunhui  | last9=Fang  | first9=Rixun }}
+*{{cite journal  | author=Brandenberger R |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971  | name-list-format=vanc | author2=Wei H  | author3=Zhang S  | display-authors=3  | last4=Lei  | first4=Shirley  | last5=Murage  | first5=Jaji  | last6=Fisk  | first6=Gregory J  | last7=Li  | first7=Yan  | last8=Xu  | first8=Chunhui  | last9=Fang  | first9=Rixun }}
-*{{cite journal  | author=Jedlitschky G |title=The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage |journal=Blood |volume=104 |issue= 12 |pages= 3603–10 |year= 2004 |pmid= 15297306 |doi= 10.1182/blood-2003-12-4330  | author-separator=,  | author2=Tirschmann K  | author3=Lubenow LE  | display-authors=3  | last4=Nieuwenhuis  | first4=HK  | last5=Akkerman  | first5=JW  | last6=Greinacher  | first6=A  | last7=Kroemer  | first7=HK }}
+*{{cite journal  | author=Jedlitschky G |title=The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage |journal=Blood |volume=104 |issue= 12 |pages= 3603–10 |year= 2004 |pmid= 15297306 |doi= 10.1182/blood-2003-12-4330  | name-list-format=vanc | author2=Tirschmann K  | author3=Lubenow LE  | display-authors=3  | last4=Nieuwenhuis  | first4=HK  | last5=Akkerman  | first5=JW  | last6=Greinacher  | first6=A  | last7=Kroemer  | first7=HK }}
-*{{cite journal  | author=Meyer Zu Schwabedissen HE |title=Expression, Localization, and Function of MRP5 (ABCC5), a Transporter for Cyclic Nucleotides, in Human Placenta and Cultured Human Trophoblasts : Effects of Gestational Age and Cellular Differentiation |journal=Am. J. Pathol. |volume=166 |issue= 1 |pages= 39–48 |year= 2005 |pmid= 15631998 |doi=  10.1016/S0002-9440(10)62230-4| pmc=1602292  | author-separator=,    }}
+*{{cite journal  | author=Meyer Zu Schwabedissen HE |title=Expression, Localization, and Function of MRP5 (ABCC5), a Transporter for Cyclic Nucleotides, in Human Placenta and Cultured Human Trophoblasts : Effects of Gestational Age and Cellular Differentiation |journal=Am. J. Pathol. |volume=166 |issue= 1 |pages= 39–48 |year= 2005 |pmid= 15631998 |doi=  10.1016/S0002-9440(10)62230-4| pmc=1602292  | name-list-format=vanc}}
 }}
 {{refend}}

v t e Membrane proteins, carrier proteins: membrane transport proteins ABC transporter (TC 3A1)
A	A1 A2 A3 A4 A7 A8 A12 A13
B	B1 B2-3 (B2 B3) B4 B5 B6 B7 B9 B11
C	C1 C2 C3 C4 C5 C6 C7 C8-9 (C8, C9) C10 C11 C13
D	D1 D2 D3 D4
E	E1
F	F1 F2
G	G1 G2 G4 Sterolin (G5, G8)
see also ABC transporter disorders

ABCC5: Difference between revisions

Revision as of 03:34, 7 March 2015

Interactive pathway map

See also

References

Further reading

External links