Curling's ulcer: Difference between revisions
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'''Curling's ulcer''' or a '''Curling ulcer''' is an [[acute (medical)|acute]] [[peptic ulcer]] of the [[duodenum]] resulting as a complication from severe burns when reduced [[blood plasma|plasma]] volume leads to ischemia and cell necrosis (sloughing) of the [[gastric mucosa]]. The condition was first described in 1823 and named for a doctor, [[Thomas Blizard Curling]], who observed ten such patients in 1842.<ref name="Pruitt">{{cite journal |author=Pruitt, Basil A., Jr., F.D. Foley and John A. Moncrief |title=Curling's ulcer: a clinical-pathology study of 323 cases |journal=Annals of Surgery |volume=172 |date=October 1970 |pmid=5311720 |issue=4 |pages=523–39 |pmc=1397279 |doi=10.1097/00000658-197010000-00001}}</ref> |
'''Curling's ulcer''' or a '''Curling ulcer''' is an [[acute (medical)|acute]] [[peptic ulcer]] of the [[duodenum]] resulting as a complication from severe burns when reduced [[blood plasma|plasma]] volume leads to ischemia and cell necrosis (sloughing) of the [[gastric mucosa]]. The condition was first described in 1823 and named for a doctor, [[Thomas Blizard Curling]], who observed ten such patients in 1842.<ref name="Pruitt">{{cite journal |author=Pruitt, Basil A., Jr., F.D. Foley and John A. Moncrief |title=Curling's ulcer: a clinical-pathology study of 323 cases |journal=Annals of Surgery |volume=172 |date=October 1970 |pmid=5311720 |issue=4 |pages=523–39 |pmc=1397279 |doi=10.1097/00000658-197010000-00001}}</ref> |
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These [[stress ulcer]]s were once a common complication of serious burns, presenting in over 10% of cases,<ref name="Pruitt" /> and especially common in child burn victims.<ref>{{cite journal |author=Bruck, H.M. and Basil A. Pruitt, Jr. |title=Curling's ulcer in children: a 12-year review of 63 cases |journal=Journal of Trauma |volume=12 |date=June 1972 |pmid=5033495 |issue=6 |pages=490–6 |doi=10.1097/00005373-197206000-00006}}</ref> They result in perforation and [[hemorrhage]] more often than other forms of intestinal ulceration<ref>{{cite journal |author=Lev R |title=Letter: Stress erosions |journal=Am J Dig Dis |volume=18 |issue=12 |pages=1099–100 |date=December 1973 |pmid=4543410 |doi=10.1007/BF01076530 |last2=Klein |first2=Martin S. |last3=Ennis |first3=Frank |last4=Sherlock |first4=Paul |last5=Winawer |first5=Sidney J. }}</ref> and had correspondingly high mortality rates (at least 80%).<ref name="Pruitt" /> <ref>{{cite book | last = Pedro-Pons | first = Agustín | title = Patología y Clínica Médicas | edition =3rd | publisher = Salvat | location = Barcelona | year = 1968 | page = 1198 | isbn = 84-345-1106-1 }}</ref> |
These [[stress ulcer]]s were once a common complication of serious burns, presenting in over 10% of cases,<ref name="Pruitt" /> and especially common in child burn victims.<ref>{{cite journal |author=Bruck, H.M. and Basil A. Pruitt, Jr. |title=Curling's ulcer in children: a 12-year review of 63 cases |journal=Journal of Trauma |volume=12 |date=June 1972 |pmid=5033495 |issue=6 |pages=490–6 |doi=10.1097/00005373-197206000-00006}}</ref> They result in perforation and [[hemorrhage]] more often than other forms of intestinal ulceration<ref>{{cite journal |author=Lev R |title=Letter: Stress erosions |journal=Am J Dig Dis |volume=18 |issue=12 |pages=1099–100 |date=December 1973 |pmid=4543410 |doi=10.1007/BF01076530 |last2=Klein |first2=Martin S. |last3=Ennis |first3=Frank |last4=Sherlock |first4=Paul |last5=Winawer |first5=Sidney J. }}</ref> and had correspondingly high mortality rates (at least 80%).<ref name="Pruitt" /> <ref>{{cite book | last = Pedro-Pons | first = Agustín | title = Patología y Clínica Médicas | edition =3rd | publisher = Salvat | location = Barcelona | year = 1968 | volume = 6 | page = 1198 | isbn = 84-345-1106-1 }}</ref> |
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A similar condition involving elevated intracranial pressure is known as [[Cushing's ulcer]]. |
A similar condition involving elevated intracranial pressure is known as [[Cushing's ulcer]]. |
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Revision as of 00:45, 9 April 2015
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Curling's ulcer or a Curling ulcer is an acute peptic ulcer of the duodenum resulting as a complication from severe burns when reduced plasma volume leads to ischemia and cell necrosis (sloughing) of the gastric mucosa. The condition was first described in 1823 and named for a doctor, Thomas Blizard Curling, who observed ten such patients in 1842.[1]
These stress ulcers were once a common complication of serious burns, presenting in over 10% of cases,[1] and especially common in child burn victims.[2] They result in perforation and hemorrhage more often than other forms of intestinal ulceration[3] and had correspondingly high mortality rates (at least 80%).[1] [4]
A similar condition involving elevated intracranial pressure is known as Cushing's ulcer.
Treatment
While emergency surgery was once the only treatment, combination therapies including enteral feeding with powerful antacids such as H2-receptor antagonists or, more recently, proton pump inhibitors such as omeprazole have made Curling's ulcer a rare complication.[5]
References
- ^ a b c Pruitt, Basil A., Jr., F.D. Foley and John A. Moncrief (October 1970). "Curling's ulcer: a clinical-pathology study of 323 cases". Annals of Surgery. 172 (4): 523–39. doi:10.1097/00000658-197010000-00001. PMC 1397279. PMID 5311720.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Bruck, H.M. and Basil A. Pruitt, Jr. (June 1972). "Curling's ulcer in children: a 12-year review of 63 cases". Journal of Trauma. 12 (6): 490–6. doi:10.1097/00005373-197206000-00006. PMID 5033495.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Lev R; Klein, Martin S.; Ennis, Frank; Sherlock, Paul; Winawer, Sidney J. (December 1973). "Letter: Stress erosions". Am J Dig Dis. 18 (12): 1099–100. doi:10.1007/BF01076530. PMID 4543410.
- ^ Pedro-Pons, Agustín (1968). Patología y Clínica Médicas. Vol. 6 (3rd ed.). Barcelona: Salvat. p. 1198. ISBN 84-345-1106-1.
- ^ Moran KT, O'Reilly T, Munster AM (October 1987). "A combined regimen for the prophylaxis of Curling's ulcer". Am Surg. 53 (10): 575–6. PMID 2890321.
{{cite journal}}: CS1 maint: multiple names: authors list (link)