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{{PBB|geneid=83992}}
{{PBB|geneid=83992}}
'''Cortactin-binding protein 2''' is a [[protein]] that in humans is encoded by the ''CTTNBP2'' [[gene]].<ref name="pmid11707066">{{vcite2 journal | vauthors = Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW | title = Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31 | journal = Genomics | volume = 78 | issue = 1-2 | pages = 7-11 | date = Nov 2001 | pmid = 11707066 | pmc = | doi = 10.1006/geno.2001.6651 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CTTNBP2 cortactin binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83992| accessdate = }}</ref>
'''Cortactin-binding protein 2''' is a [[protein]] that in humans is encoded by the ''CTTNBP2'' [[gene]].<ref name="pmid11707066">{{vcite2 journal | vauthors = Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW | title = Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31 | journal = Genomics | volume = 78 | issue = 1-2 | pages = 7–11 | date = Nov 2001 | pmid = 11707066 | pmc = | doi = 10.1006/geno.2001.6651 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CTTNBP2 cortactin binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83992| accessdate = }}</ref>


== Function ==
== Function ==
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* [[MOBKL3]],<ref name = pmid18782753/>
* [[MOBKL3]],<ref name = pmid18782753/>
* [[PPP2CA]],<ref name = pmid18782753/>
* [[PPP2CA]],<ref name = pmid18782753/>
* [[RP6-213H19.1]],<ref name = pmid18782753>{{vcite2 journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Mol. Cell Proteomics | volume = 8 | issue = 1 | pages = 157-71 | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 }}</ref>
* [[RP6-213H19.1]],<ref name = pmid18782753>{{vcite2 journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Mol. Cell Proteomics | volume = 8 | issue = 1 | pages = 157–71 | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 }}</ref>
* [[STRN3]],<ref name = pmid18782753/> and
* [[STRN3]],<ref name = pmid18782753/> and
* [[STRN]].<ref name = pmid18782753/>
* [[STRN]].<ref name = pmid18782753/>

⚫
==Model organisms==
⚫
[[Model organism]]s have been used in the study of CTTNBP2 function. A conditional [[knockout mouse]] line called ''Cttnbp2<sup>tm1b(KOMP)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite web |url=http://onlinelibrary.wiley.com/doi/10.1111/j.1755-3768.2010.4142.x/abstract |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |location=''Acta Opthalmologica'' '''88''': 925-7.doi:10.1111/j.1755-3768.2010.4142.x |publisher=Wiley}}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Cttnbp2#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{vcite2 journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337â€"42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{vcite2 journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{vcite2 journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9â€"13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{vcite2 journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | year = 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022}}</ref> Additional screens performed: - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Cttnbp2&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>


⚫
==Model organisms==
⚫
[[Model organism]]s have been used in the study of CTTNBP2 function. A conditional [[knockout mouse]] line called ''Cttnbp2<sup>tm1b(KOMP)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]] <ref name="mgp_reference">{{cite web |url=http://onlinelibrary.wiley.com/doi/10.1111/j.1755-3768.2010.4142.x/abstract |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |location=''Acta Opthalmologica'' '''88''': 925-7.doi:10.1111/j.1755-3768.2010.4142.x |publisher=Wiley}}</ref>. Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Cttnbp2#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{vcite2 journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{vcite2 journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262-3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{vcite2 journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{vcite2 journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452-64 | year = 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022}} </ref> Additional screens performed: - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Cttnbp2&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
|+ ''Cttnbp2'' knockout mouse phenotype
|+ ''Cttnbp2'' knockout mouse phenotype
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! Characteristic!! Phenotype
! Characteristic!! Phenotype
|-
|-
| colspan=2; style="text-align: center;" | All data available at <ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Cttnbp2#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref><ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=aldh3b1&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>.
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Cttnbp2#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref><ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=aldh3b1&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>


|-
|-
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|-
|-
| [[Dual-energy_X-ray_absorptiometry|DEXA]] || bgcolor="#C40000"|Abnormal
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#C40000"|Abnormal


|-
|-
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|-
|-
|}
|}''</br>.




==References==
==References==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{vcite2 journal | vauthors = Ohoka Y, Takai Y | title = Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90 | journal = Genes Cells | volume = 3 | issue = 9 | pages = 603-12 | year = 1998 | pmid = 9813110 | doi = 10.1046/j.1365-2443.1998.00216.x }}
* {{vcite2 journal | vauthors = Ohoka Y, Takai Y | title = Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90 | journal = Genes Cells | volume = 3 | issue = 9 | pages = 603–12 | year = 1998 | pmid = 9813110 | doi = 10.1046/j.1365-2443.1998.00216.x }}
* {{vcite2 journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 6 | pages = 347-55 | year = 2000 | pmid = 11214970 | doi = 10.1093/dnares/7.6.347 }}
* {{vcite2 journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 6 | pages = 347–55 | year = 2000 | pmid = 11214970 | doi = 10.1093/dnares/7.6.347 }}
* {{vcite2 journal | vauthors = Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D | title = Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei | journal = J. Cell Biol. | volume = 166 | issue = 6 | pages = 815-25 | year = 2004 | pmid = 15364959 | pmc = 2172106 | doi = 10.1083/jcb.200404107 }}
* {{vcite2 journal | vauthors = Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D | title = Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei | journal = J. Cell Biol. | volume = 166 | issue = 6 | pages = 815–25 | year = 2004 | pmid = 15364959 | pmc = 2172106 | doi = 10.1083/jcb.200404107 }}
{{refend}}
{{refend}}



{{gene-7-stub}}
{{gene-7-stub}}

Revision as of 04:25, 20 May 2015

Template:PBB Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene.[1][2]

Function

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.[2]

Interactions

CTTNBP2 has been shown to interact with:

Model organisms

Model organisms have been used in the study of CTTNBP2 function. A conditional knockout mouse line called Cttnbp2tm1b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[4] Male and female animals underwent a standardized phenotypic screen[5] to determine the effects of deletion.[6][7][8][9] Additional screens performed: - In-depth immunological phenotyping[10]

References

  1. ^ Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics. 78 (1–2): 7–11. doi:10.1006/geno.2001.6651. PMID 11707066.
  2. ^ a b "Entrez Gene: CTTNBP2 cortactin binding protein 2".
  3. ^ a b c d e Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley.{{cite web}}: CS1 maint: location (link)
  5. ^ a b "International Mouse Phenotyping Consortium".
  6. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337â€"42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  7. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  8. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9â€"13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  9. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse GP, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. {{cite journal}}: Vancouver style error: initials in name 17 (help)
  10. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". Cite error: The named reference "iii_ref" was defined multiple times with different content (see the help page).

Further reading


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