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{{PBB|geneid=664}}
{{PBB|geneid=664}}
'''BCL2/adenovirus E1B 19 kDa protein-interacting protein 3''' is a [[protein]] that in humans is encoded by the ''BNIP3'' [[gene]].<ref name="pmid7954800">{{cite journal | author = Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G | title = Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins | journal = Cell | volume = 79 | issue = 2 | pages = 341–51 |date=November 1994 | pmid = 7954800 | pmc = | doi =10.1016/0092-8674(94)90202-X }}</ref>
'''BCL2/adenovirus E1B 19 kDa protein-interacting protein 3''' is a [[protein]] that in humans is encoded by the ''BNIP3'' [[gene]].<ref name="pmid7954800">{{cite journal | vauthors = Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G | title = Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins | journal = Cell | volume = 79 | issue = 2 | pages = 341–51 | date = Oct 1994 | pmid = 7954800 | pmc = | doi = 10.1016/0092-8674(94)90202-X }}</ref>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
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| summary_text = This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. This gene contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.<ref name="entrez">{{cite web | title = Entrez Gene: BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=664| accessdate = }}</ref>
}}


⚫
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. This gene contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.<ref name="entrez">{{cite web | title = Entrez Gene: BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=664| accessdate = }}</ref>
==Interactions==
⚫
BNIP3 has been shown to [[Protein-protein interaction|interact]] with [[CD47]],<ref name=pmid12690108>{{cite journal |last=Lamy |first=Laurence |authorlink= |author2=Ticchioni Michel |author3=Rouquette-Jazdanian Alexandre K |author4=Samson Michel |author5=Deckert Marcel |author6=Greenberg Arnold H |author7=Bernard Alain |date=June 2003 |title=CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis |journal=J. Biol. Chem. |volume=278 |issue=26 |pages=23915–21 |publisher= |location = United States| issn = 0021-9258| pmid = 12690108 |doi = 10.1074/jbc.M301869200 }}</ref> [[BCL2-like 1 (gene)|BCL2-like 1]]<ref name=pmid10625696>{{cite journal |last=Ray |first=R |authorlink= |author2=Chen G|author3=Vande Velde C|author4=Cizeau J|author5=Park J H|author6=Reed J C|author7=Gietz R D|author8=Greenberg A H |date=January 2000 |title=BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites |journal=J. Biol. Chem. |volume=275 |issue=2 |pages=1439–48 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10625696 |doi=10.1074/jbc.275.2.1439 }}</ref> and [[Bcl-2]].<ref name=pmid7954800>{{cite journal |last=Boyd |first=J M |authorlink= |author2=Malstrom S |author3=Subramanian T |author4=Venkatesh L K |author5=Schaeper U |author6=Elangovan B |author7=D'Sa-Eipper C |author8=Chinnadurai G |date=October 1994 |title=Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins |journal=Cell |volume=79 |issue=2 |pages=341–51 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 7954800 |doi=10.1016/0092-8674(94)90202-X }}</ref><ref name=pmid10625696/>


==References==
== Interactions ==

⚫
BNIP3 has been shown to [[Protein-protein interaction|interact]] with [[CD47]],<ref name=pmid12690108>{{cite journal | vauthors = Lamy L, Ticchioni M, Rouquette-Jazdanian AK, Samson M, Deckert M, Greenberg AH, Bernard A | title = CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 26 | pages = 23915–21 | date = Jun 2003 | pmid = 12690108 | doi = 10.1074/jbc.M301869200 }}</ref> [[BCL2-like 1 (gene)|BCL2-like 1]]<ref name=pmid10625696>{{cite journal | vauthors = Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, Gietz RD, Greenberg AH | title = BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites | journal = The Journal of Biological Chemistry | volume = 275 | issue = 2 | pages = 1439–48 | date = Jan 2000 | pmid = 10625696 | doi = 10.1074/jbc.275.2.1439 }}</ref> and [[Bcl-2]].<ref name=pmid7954800>{{cite journal | vauthors = Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G | title = Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins | journal = Cell | volume = 79 | issue = 2 | pages = 341–51 | date = Oct 1994 | pmid = 7954800 | doi = 10.1016/0092-8674(94)90202-X }}</ref><ref name=pmid10625696/>

== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Kataoka N, Ohno M, Moda I, Shimura Y | title = Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein | journal = Nucleic Acids Research | volume = 23 | issue = 18 | pages = 3638–41 | date = Sep 1995 | pmid = 7478990 | pmc = 307259 | doi = 10.1093/nar/23.18.3638 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
*{{cite journal | author=Kataoka N, Ohno M, Moda I, Shimura Y |title=Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein. |journal=Nucleic Acids Res. |volume=23 |issue= 18 |pages= 3638–41 |year= 1995 |pmid= 7478990 |doi=10.1093/nar/23.18.3638 | pmc=307259 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Chen G, Ray R, Dubik D, Shi L, Cizeau J, Bleackley RC, Saxena S, Gietz RD, Greenberg AH | title = The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis | journal = The Journal of Experimental Medicine | volume = 186 | issue = 12 | pages = 1975–83 | date = Dec 1997 | pmid = 9396766 | pmc = 2199165 | doi = 10.1084/jem.186.12.1975 }}
* {{cite journal | vauthors = Yasuda M, Theodorakis P, Subramanian T, Chinnadurai G | title = Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence | journal = The Journal of Biological Chemistry | volume = 273 | issue = 20 | pages = 12415–21 | date = May 1998 | pmid = 9575197 | doi = 10.1074/jbc.273.20.12415 }}
*{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 | author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }}
* {{cite journal | vauthors = Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, Shi L, Dubik D, Greenberg A | title = Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins | journal = The Journal of Biological Chemistry | volume = 274 | issue = 1 | pages = 7–10 | date = Jan 1999 | pmid = 9867803 | doi = 10.1074/jbc.274.1.7 }}
*{{cite journal | author=Chen G |title=The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis |journal=J. Exp. Med. |volume=186 |issue= 12 |pages= 1975–83 |year= 1998 |pmid= 9396766 |doi=10.1084/jem.186.12.1975 | pmc=2199165 | author2=Ray R | author3=Dubik D | display-authors=3 | last4=Shi | first4=L | last5=Cizeau | first5=J | last6=Bleackley | first6=RC | last7=Saxena | first7=S | last8=Gietz | first8=RD | last9=Greenberg | first9=AH }}
*{{cite journal | author=Yasuda M, Theodorakis P, Subramanian T, Chinnadurai G |title=Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence |journal=J. Biol. Chem. |volume=273 |issue= 20 |pages= 12415–21 |year= 1998 |pmid= 9575197 |doi=10.1074/jbc.273.20.12415 }}
* {{cite journal | vauthors = Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G | title = BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3 | journal = Cancer Research | volume = 59 | issue = 3 | pages = 533–7 | date = Feb 1999 | pmid = 9973195 | doi = }}
⚫
* {{cite journal | vauthors = Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, Motoyama N, Nakajima T | title = A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region | journal = Cell Death and Differentiation | volume = 6 | issue = 4 | pages = 314–25 | date = Apr 1999 | pmid = 10381623 | doi = 10.1038/sj.cdd.4400493 }}
*{{cite journal | author=Chen G |title=Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins |journal=J. Biol. Chem. |volume=274 |issue= 1 |pages= 7–10 |year= 1999 |pmid= 9867803 |doi=10.1074/jbc.274.1.7 | author2=Cizeau J | author3=Vande Velde C | display-authors=3 | last4=Park | first4=JH | last5=Bozek | first5=G | last6=Bolton | first6=J | last7=Shi | first7=L | last8=Dubik | first8=D | last9=Greenberg | first9=A }}
⚫
* {{cite journal | vauthors = Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, Gietz RD, Greenberg AH | title = BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites | journal = The Journal of Biological Chemistry | volume = 275 | issue = 2 | pages = 1439–48 | date = Jan 2000 | pmid = 10625696 | doi = 10.1074/jbc.275.2.1439 }}
*{{cite journal | author=Yasuda M |title=BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3 |journal=Cancer Res. |volume=59 |issue= 3 |pages= 533–7 |year= 1999 |pmid= 9973195 |doi= | author2=Han JW | author3=Dionne CA | display-authors=3 | last4=Boyd | first4=JM | last5=Chinnadurai | first5=G }}
* {{cite journal | vauthors = Vande Velde C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, Hakem R, Greenberg AH | title = BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore | journal = Molecular and Cellular Biology | volume = 20 | issue = 15 | pages = 5454–68 | date = Aug 2000 | pmid = 10891486 | pmc = 85997 | doi = 10.1128/MCB.20.15.5454-5468.2000 }}
⚫
*{{cite journal | author=Ohi N |title=A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 314–25 |year= 1999 |pmid= 10381623 |doi= 10.1038/sj.cdd.4400493 | author2=Tokunaga A | author3=Tsunoda H | display-authors=3 | last4=Nakano | first4=Kazuhiro | last5=Haraguchi | first5=Keiko | last6=Oda | first6=Kinichiro | last7=Motoyama | first7=Noboru | last8=Nakajima | first8=Takuma }}
⚫
* {{cite journal | vauthors = Lee SM, Li ML, Tse YC, Leung SC, Lee MM, Tsui SK, Fung KP, Lee CY, Waye MM | title = Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway | journal = Life Sciences | volume = 71 | issue = 19 | pages = 2267–77 | date = Sep 2002 | pmid = 12215374 | doi = 10.1016/S0024-3205(02)01962-8 }}
⚫
*{{cite journal | author=Ray R |title=BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites |journal=J. Biol. Chem. |volume=275 |issue= 2 |pages= 1439–48 |year= 2000 |pmid= 10625696 |doi=10.1074/jbc.275.2.1439 | author2=Chen G | author3=Vande Velde C | display-authors=3 | last4=Cizeau | first4=J | last5=Park | first5=JH | last6=Reed | first6=JC | last7=Gietz | first7=RD | last8=Greenberg | first8=AH }}
* {{cite journal | vauthors = Lamy L, Ticchioni M, Rouquette-Jazdanian AK, Samson M, Deckert M, Greenberg AH, Bernard A | title = CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 26 | pages = 23915–21 | date = Jun 2003 | pmid = 12690108 | doi = 10.1074/jbc.M301869200 }}
*{{cite journal | author=Vande Velde C |title=BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore |journal=Mol. Cell. Biol. |volume=20 |issue= 15 |pages= 5454–68 |year= 2000 |pmid= 10891486 |doi=10.1128/MCB.20.15.5454-5468.2000 | pmc=85997 | author2=Cizeau J | author3=Dubik D | display-authors=3 | last4=Alimonti | first4=J. | last5=Brown | first5=T. | last6=Israels | first6=S. | last7=Hakem | first7=R. | last8=Greenberg | first8=A. H. }}
⚫
* {{cite journal | vauthors = Kothari S, Cizeau J, McMillan-Ward E, Israels SJ, Bailes M, Ens K, Kirshenbaum LA, Gibson SB | title = BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF | journal = Oncogene | volume = 22 | issue = 30 | pages = 4734–44 | date = Jul 2003 | pmid = 12879018 | doi = 10.1038/sj.onc.1206666 }}
⚫
*{{cite journal | author=Lee SM |title=Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway |journal=Life Sci. |volume=71 |issue= 19 |pages= 2267–77 |year= 2002 |pmid= 12215374 |doi=10.1016/S0024-3205(02)01962-8 | author2=Li ML | author3=Tse YC | display-authors=3 | last4=Leung | first4=SC | last5=Lee | first5=MM | last6=Tsui | first6=SK | last7=Fung | first7=KP | last8=Lee | first8=CY | last9=Waye | first9=MM }}
⚫
* {{cite journal | vauthors = Okami J, Simeone DM, Logsdon CD | title = Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer | journal = Cancer Research | volume = 64 | issue = 15 | pages = 5338–46 | date = Aug 2004 | pmid = 15289340 | doi = 10.1158/0008-5472.CAN-04-0089 }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
⚫
* {{cite journal | vauthors = Giatromanolaki A, Koukourakis MI, Sowter HM, Sivridis E, Gibson S, Gatter KC, Harris AL | title = BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer | journal = Clinical Cancer Research | volume = 10 | issue = 16 | pages = 5566–71 | date = Aug 2004 | pmid = 15328198 | doi = 10.1158/1078-0432.CCR-04-0076 }}
*{{cite journal | author=Lamy L |title=CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23915–21 |year= 2003 |pmid= 12690108 |doi= 10.1074/jbc.M301869200 | author2=Ticchioni M | author3=Rouquette-Jazdanian AK | display-authors=3 | last4=Samson | first4=M | last5=Deckert | first5=M | last6=Greenberg | first6=AH | last7=Bernard | first7=A }}
⚫
* {{cite journal | vauthors = Shen XY, Zacal N, Singh G, Rainbow AJ | title = Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells | journal = Photochemistry and Photobiology | volume = 81 | issue = 2 | pages = 306–13 | year = 2005 | pmid = 15560738 | doi = 10.1562/2004-07-22-RA-242 }}
⚫
*{{cite journal | author=Kothari S |title=BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF |journal=Oncogene |volume=22 |issue= 30 |pages= 4734–44 |year= 2003 |pmid= 12879018 |doi= 10.1038/sj.onc.1206666 | author2=Cizeau J | author3=McMillan-Ward E | display-authors=3 | last4=Israels | first4=Sara J | last5=Bailes | first5=Michelle | last6=Ens | first6=Karen | last7=Kirshenbaum | first7=Lorrie A | last8=Gibson | first8=Spencer B }}
*{{cite journal | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 | author2=Earthrowl ME | author3=Grafham DV | display-authors=3 | last4=Rubenfield | first4=M. | last5=French | first5=L. | last6=Steward | first6=C. A. | last7=Sims | first7=S. K. | last8=Jones | first8=M. C. | last9=Searle | first9=S. }}
⚫
*{{cite journal | author=Okami J, Simeone DM, Logsdon CD |title=Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer |journal=Cancer Res. |volume=64 |issue= 15 |pages= 5338–46 |year= 2004 |pmid= 15289340 |doi= 10.1158/0008-5472.CAN-04-0089 }}
⚫
*{{cite journal | author=Giatromanolaki A |title=BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer |journal=Clin. Cancer Res. |volume=10 |issue= 16 |pages= 5566–71 |year= 2005 |pmid= 15328198 |doi= 10.1158/1078-0432.CCR-04-0076 | author2=Koukourakis MI | author3=Sowter HM | display-authors=3 | last4=Sivridis | first4=E | last5=Gibson | first5=S | last6=Gatter | first6=KC | last7=Harris | first7=AL }}
*{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
⚫
*{{cite journal | author=Shen XY, Zacal N, Singh G, Rainbow AJ |title=Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells |journal=Photochem. Photobiol. |volume=81 |issue= 2 |pages= 306–13 |year= 2005 |pmid= 15560738 |doi= 10.1562/2004-07-22-RA-242 }}
}}
{{refend}}
{{refend}}
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{{PDB Gallery|geneid=664}}

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{{PDB Gallery|geneid=664}}


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Revision as of 08:31, 8 August 2015

Template:PBB BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 is a protein that in humans is encoded by the BNIP3 gene.[1]

Function

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. This gene contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.[2]

Interactions

BNIP3 has been shown to interact with CD47,[3] BCL2-like 1[4] and Bcl-2.[1][4]

References

  1. ^ a b Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G (Oct 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341–51. doi:10.1016/0092-8674(94)90202-X. PMID 7954800. Cite error: The named reference "pmid7954800" was defined multiple times with different content (see the help page).
  2. ^ "Entrez Gene: BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3".
  3. ^ Lamy L, Ticchioni M, Rouquette-Jazdanian AK, Samson M, Deckert M, Greenberg AH, Bernard A (Jun 2003). "CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis". The Journal of Biological Chemistry. 278 (26): 23915–21. doi:10.1074/jbc.M301869200. PMID 12690108.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ a b Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, Gietz RD, Greenberg AH (Jan 2000). "BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites". The Journal of Biological Chemistry. 275 (2): 1439–48. doi:10.1074/jbc.275.2.1439. PMID 10625696.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Further reading

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