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A '''wakefulness-promoting agent''', or '''eugeroic''', is a type of [[drug]] which specifically improves [[wakefulness]] and [[alertness]].<ref name="Modafinil" /><ref name="Armodafinil" /> They are used mainly in the [[therapy|treatment]] of [[sleeping disorder]]s, [[excessive daytime sleepiness]] and [[narcolepsy]].<ref name="Modafinil" /><ref name="Armodafinil" /> They are also used merely to counteract [[fatigue (medical)|fatigue]] and [[lethargy]] and to enhance [[motivation]] and [[productivity]].{{medcn|date=April 2015}} Wakefulness-promoting agents are [[addictive]],<ref name="Modafinil" /><ref name="Armodafinil" /> although not necessarily to the same extent as other addictive stimulants or caffeine. While caffeine is moderately addictive, wakefulness enhancers are only mildly addictive.
A '''wakefulness-promoting agent''', or '''eugeroic''', is a type of [[drug]] which specifically improves [[wakefulness]] and [[alertness]].<ref name="Modafinil" /><ref name="Armodafinil" /> They are used mainly in the [[therapy|treatment]] of [[sleeping disorder]]s, [[excessive daytime sleepiness]] and [[narcolepsy]].<ref name="Modafinil" /><ref name="Armodafinil" /> They are also used merely to counteract [[fatigue (medical)|fatigue]] and [[lethargy]] and to enhance [[motivation]] and [[productivity]].{{medcn|date=April 2015}} Wakefulness-promoting agents are [[addictive]],<ref name="Modafinil" /><ref name="Armodafinil" /> although not necessarily to the same extent as other addictive stimulants.


The prototypical eugeroic is [[modafinil]], and other drugs include [[adrafinil]] and [[armodafinil]]. Modafinil and armodafinil are [[dopamine reuptake inhibitor]]s.<ref name="Modafinil">{{cite web|title=Provigil: Prescribing information|url=http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020717s037s038lbl.pdf|website=United States Food and Drug Administration|publisher=Cephalon, Inc|accessdate=16 August 2015|date=January 2015}}</ref><ref name="Armodafinil">{{cite web|title=Nuvigil: Prescribing information|url=http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021875s021lbledt.pdf|website=United States Food and Drug Administration|publisher=Cephalon, Inc|accessdate=16 August 2015|date=April 2015}}</ref>
The prototypical eugeroic is [[modafinil]], and other drugs include [[adrafinil]] and [[armodafinil]]. Modafinil and armodafinil are [[dopamine reuptake inhibitor]]s.<ref name="Modafinil">{{cite web|title=Provigil: Prescribing information|url=http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020717s037s038lbl.pdf|website=United States Food and Drug Administration|publisher=Cephalon, Inc|accessdate=16 August 2015|date=January 2015}}</ref><ref name="Armodafinil">{{cite web|title=Nuvigil: Prescribing information|url=http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021875s021lbledt.pdf|website=United States Food and Drug Administration|publisher=Cephalon, Inc|accessdate=16 August 2015|date=April 2015}}</ref>

Revision as of 06:21, 27 August 2015

A wakefulness-promoting agent, or eugeroic, is a type of drug which specifically improves wakefulness and alertness.[1][2] They are used mainly in the treatment of sleeping disorders, excessive daytime sleepiness and narcolepsy.[1][2] They are also used merely to counteract fatigue and lethargy and to enhance motivation and productivity.[medical citation needed] Wakefulness-promoting agents are addictive,[1][2] although not necessarily to the same extent as other addictive stimulants.

The prototypical eugeroic is modafinil, and other drugs include adrafinil and armodafinil. Modafinil and armodafinil are dopamine reuptake inhibitors.[1][2]

The functional opposites of wakefulness-promoting agents are hypnotics, such as H1 antihistamines that cross the blood–brain barrier and suvorexant, an orexin antagonist.

Examples

Wakefulness Reducing Agent

The only functional opposite of wakefulness enhancing agents.

See also

References

  1. ^ a b c d "Provigil: Prescribing information" (PDF). United States Food and Drug Administration. Cephalon, Inc. January 2015. Retrieved 16 August 2015.
  2. ^ a b c d "Nuvigil: Prescribing information" (PDF). United States Food and Drug Administration. Cephalon, Inc. April 2015. Retrieved 16 August 2015.
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