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*{{cite journal | author=Farid NR, Kascur V, Balazs C |title=The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations. |journal=Eur. J. Endocrinol. |volume=143 |issue= 1 |pages= 25–30 |year= 2000 |pmid= 10870027 |doi=10.1530/eje.0.1430025 }}
*{{cite journal | author=Farid NR, Kascur V, Balazs C |title=The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations. |journal=Eur. J. Endocrinol. |volume=143 |issue= 1 |pages= 25–30 |year= 2000 |pmid= 10870027 |doi=10.1530/eje.0.1430025 }}
*{{cite journal | author=Szkudlinski MW, Fremont V, Ronin C, Weintraub BD |title=Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. |journal=Physiol. Rev. |volume=82 |issue= 2 |pages= 473–502 |year= 2002 |pmid= 11917095 |doi= 10.1152/physrev.00031.2001 }}
*{{cite journal | author=Szkudlinski MW, Fremont V, Ronin C, Weintraub BD |title=Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. |journal=Physiol. Rev. |volume=82 |issue= 2 |pages= 473–502 |year= 2002 |pmid= 11917095 |doi= 10.1152/physrev.00031.2001 }}
*{{cite journal | author=Tonacchera M, Vitti P, De Servi M, ''et al.'' |title=Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis. |journal=J. Endocrinol. Invest. |volume=26 |issue= 2 Suppl |pages= 2–6 |year= 2004 |pmid= 12762632 |doi= }}
*{{cite journal |vauthors=Tonacchera M, Vitti P, De Servi M, etal |title=Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis. |journal=J. Endocrinol. Invest. |volume=26 |issue= 2 Suppl |pages= 2–6 |year= 2004 |pmid= 12762632 |doi= }}
*{{cite journal | author=Arturi F, Scarpelli D, Coco A, ''et al.'' |title=Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions. |journal=Thyroid |volume=13 |issue= 4 |pages= 341–3 |year= 2004 |pmid= 12804102 |doi= 10.1089/105072503321669811 }}
*{{cite journal |vauthors=Arturi F, Scarpelli D, Coco A, etal |title=Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions. |journal=Thyroid |volume=13 |issue= 4 |pages= 341–3 |year= 2004 |pmid= 12804102 |doi= 10.1089/105072503321669811 }}
*{{cite journal | author=Vaidya B, Campbell V, Tripp JH, ''et al.'' |title=Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation. |journal=Clin. Endocrinol. (Oxf) |volume=60 |issue= 6 |pages= 711–8 |year= 2004 |pmid= 15163335 |doi= 10.1111/j.1365-2265.2004.02040.x }}
*{{cite journal |vauthors=Vaidya B, Campbell V, Tripp JH, etal |title=Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation. |journal=Clin. Endocrinol. (Oxf) |volume=60 |issue= 6 |pages= 711–8 |year= 2004 |pmid= 15163335 |doi= 10.1111/j.1365-2265.2004.02040.x }}
*{{cite journal | author=Takeshita A, Nagayama Y, Fujiyama K, ''et al.'' |title=Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript. |journal=Biochem. Biophys. Res. Commun. |volume=188 |issue= 3 |pages= 1214–9 |year= 1992 |pmid= 1445355 |doi=10.1016/0006-291X(92)91360-3 }}
*{{cite journal |vauthors=Takeshita A, Nagayama Y, Fujiyama K, etal |title=Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript. |journal=Biochem. Biophys. Res. Commun. |volume=188 |issue= 3 |pages= 1214–9 |year= 1992 |pmid= 1445355 |doi=10.1016/0006-291X(92)91360-3 }}
*{{cite journal | author=Graves PN, Tomer Y, Davies TF |title=Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 2 |pages= 1135–43 |year= 1992 |pmid= 1530609 |doi=10.1016/0006-291X(92)91315-H }}
*{{cite journal | author=Graves PN, Tomer Y, Davies TF |title=Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 2 |pages= 1135–43 |year= 1992 |pmid= 1530609 |doi=10.1016/0006-291X(92)91315-H }}
*{{cite journal | author=Loosfelt H, Pichon C, Jolivet A, ''et al.'' |title=Two-subunit structure of the human thyrotropin receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 9 |pages= 3765–9 |year= 1992 |pmid= 1570295 |doi=10.1073/pnas.89.9.3765 | pmc=525571 }}
*{{cite journal |vauthors=Loosfelt H, Pichon C, Jolivet A, etal |title=Two-subunit structure of the human thyrotropin receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 9 |pages= 3765–9 |year= 1992 |pmid= 1570295 |doi=10.1073/pnas.89.9.3765 | pmc=525571 }}
*{{cite journal | author=Nagayama Y, Russo D, Wadsworth HL, ''et al.'' |title=Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding |journal=J. Biol. Chem. |volume=266 |issue= 23 |pages= 14926–30 |year= 1991 |pmid= 1651314 |doi= }}
*{{cite journal |vauthors=Nagayama Y, Russo D, Wadsworth HL, etal |title=Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding |journal=J. Biol. Chem. |volume=266 |issue= 23 |pages= 14926–30 |year= 1991 |pmid= 1651314 |doi= }}
*{{cite journal | author=Murakami M, Mori M |title=Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease |journal=Biochem. Biophys. Res. Commun. |volume=171 |issue= 1 |pages= 512–8 |year= 1990 |pmid= 1697467 |doi=10.1016/0006-291X(90)91423-P }}
*{{cite journal | author=Murakami M, Mori M |title=Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease |journal=Biochem. Biophys. Res. Commun. |volume=171 |issue= 1 |pages= 512–8 |year= 1990 |pmid= 1697467 |doi=10.1016/0006-291X(90)91423-P }}
*{{cite journal | author=Heldin NE, Gustavsson B, Westermark K, Westermark B |title=A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism |journal=J. Clin. Endocrinol. Metab. |volume=73 |issue= 6 |pages= 1374–6 |year= 1992 |pmid= 1955520 |doi=10.1210/jcem-73-6-1374 }}
*{{cite journal | author=Heldin NE, Gustavsson B, Westermark K, Westermark B |title=A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism |journal=J. Clin. Endocrinol. Metab. |volume=73 |issue= 6 |pages= 1374–6 |year= 1992 |pmid= 1955520 |doi=10.1210/jcem-73-6-1374 }}
*{{cite journal | author=Libert F, Passage E, Lefort A, ''et al.'' |title=Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=54 |issue= 1–2 |pages= 82–3 |year= 1991 |pmid= 2249482 |doi=10.1159/000132964 }}
*{{cite journal |vauthors=Libert F, Passage E, Lefort A, etal |title=Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=54 |issue= 1–2 |pages= 82–3 |year= 1991 |pmid= 2249482 |doi=10.1159/000132964 }}
*{{cite journal | author=Frazier AL, Robbins LS, Stork PJ, ''et al.'' |title=Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing |journal=Mol. Endocrinol. |volume=4 |issue= 8 |pages= 1264–76 |year= 1991 |pmid= 2293030 |doi=10.1210/mend-4-8-1264 }}
*{{cite journal |vauthors=Frazier AL, Robbins LS, Stork PJ, etal |title=Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing |journal=Mol. Endocrinol. |volume=4 |issue= 8 |pages= 1264–76 |year= 1991 |pmid= 2293030 |doi=10.1210/mend-4-8-1264 }}
*{{cite journal | author=Misrahi M, Loosfelt H, Atger M, ''et al.'' |title=Cloning, sequencing and expression of human TSH receptor |journal=Biochem. Biophys. Res. Commun. |volume=166 |issue= 1 |pages= 394–403 |year= 1990 |pmid= 2302212 |doi=10.1016/0006-291X(90)91958-U }}
*{{cite journal |vauthors=Misrahi M, Loosfelt H, Atger M, etal |title=Cloning, sequencing and expression of human TSH receptor |journal=Biochem. Biophys. Res. Commun. |volume=166 |issue= 1 |pages= 394–403 |year= 1990 |pmid= 2302212 |doi=10.1016/0006-291X(90)91958-U }}
*{{cite journal | author=Nagayama Y, Kaufman KD, Seto P, Rapoport B |title=Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue= 3 |pages= 1184–90 |year= 1990 |pmid= 2558651 |doi=10.1016/0006-291X(89)92727-7 }}
*{{cite journal | author=Nagayama Y, Kaufman KD, Seto P, Rapoport B |title=Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue= 3 |pages= 1184–90 |year= 1990 |pmid= 2558651 |doi=10.1016/0006-291X(89)92727-7 }}
*{{cite journal | author=Libert F, Lefort A, Gerard C, ''et al.'' |title=Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue= 3 |pages= 1250–5 |year= 1990 |pmid= 2610690 |doi=10.1016/0006-291X(89)92736-8 }}
*{{cite journal |vauthors=Libert F, Lefort A, Gerard C, etal |title=Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue= 3 |pages= 1250–5 |year= 1990 |pmid= 2610690 |doi=10.1016/0006-291X(89)92736-8 }}
*{{cite journal | author=Cuddihy RM, Bryant WP, Bahn RS |title=Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor |journal=Thyroid |volume=5 |issue= 4 |pages= 255–7 |year= 1996 |pmid= 7488864 |doi=10.1089/thy.1995.5.255 }}
*{{cite journal | author=Cuddihy RM, Bryant WP, Bahn RS |title=Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor |journal=Thyroid |volume=5 |issue= 4 |pages= 255–7 |year= 1996 |pmid= 7488864 |doi=10.1089/thy.1995.5.255 }}
*{{cite journal | author=Bahn RS, Dutton CM, Heufelder AE, Sarkar G |title=A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy |journal=J. Clin. Endocrinol. Metab. |volume=78 |issue= 2 |pages= 256–60 |year= 1994 |pmid= 7508946 |doi=10.1210/jc.78.2.256 }}
*{{cite journal | author=Bahn RS, Dutton CM, Heufelder AE, Sarkar G |title=A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy |journal=J. Clin. Endocrinol. Metab. |volume=78 |issue= 2 |pages= 256–60 |year= 1994 |pmid= 7508946 |doi=10.1210/jc.78.2.256 }}
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==External links==
==External links==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2988 | title = Glycoprotein Hormone Receptors: TSH | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2988 | title = Glycoprotein Hormone Receptors: TSH | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* {{MeshName|Thyrotropin+Receptors}}
* {{MeshName|Thyrotropin+Receptors}}
* [http://gris.ulb.ac.be GRIS: Glycoprotein-hormone Receptor Information System]
* [http://gris.ulb.ac.be GRIS: Glycoprotein-hormone Receptor Information System]

Revision as of 12:55, 2 September 2015

Not to be confused with Thyrotropin-releasing hormone or Thyrotropin-releasing hormone receptor.

Template:PBB The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins[1] and is coupled to the Gs protein.[2]

It is primarily found on the surface of the thyroid epithelial cells.

Function

Upon binding circulating thyrotropin, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping; thyroglobulin synthesis, iodination, endocytosis and proteolysis; thyroid peroxidase activity; and hormone release.

See also

References

  1. ^ Farid NR, Szkudlinski MW (2004). "Minireview: structural and functional evolution of the thyrotropin receptor". Endocrinology. 145 (9): 4048–57. doi:10.1210/en.2004-0437. PMID 15231707.
  2. ^ Calebiro D, Nikolaev VO, Lohse MJ (July 2010). "Imaging of persistent cAMP signaling by internalized G protein-coupled receptors". J. Mol. Endocrinol. 45 (1): 1–8. doi:10.1677/JME-10-0014. PMID 20378719.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Further reading

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