Tavilermide: Difference between revisions

Tavilermide
Clinical data
Routes of; administration	Eye drop
ATC code	None;
Identifiers
	IUPAC name 3-[(5S,8S,11S)-8-(4-aminobutyl)-5-(carboxymethylcarbamoyl)-16-nitro-7,10,13-trioxo-2-oxa-6,9,12-triazabicyclo[12.4.0]octadeca-1(14),15,17-trien-11-yl]propanoic acid;
CAS Number	263251-78-1;
PubChem CID	9808372;
ChemSpider	7984131;
CompTox Dashboard (EPA)	DTXSID00180937 ;
Chemical and physical data
Formula	C24H32N6O11
Molar mass	580.54448 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1COC2=C(C=C(C=C2)[N+](=O)[O-])C(=O)NC(C(=O)NC(C(=O)NC1C(=O)NCC(=O)O)CCCCN)CCC(=O)O;

Browse history interactively

← Previous edit Next edit →

Content deleted Content added

VisualWikitext

Inline

Revision as of 16:15, 4 November 2015

Tavilermide (INN) (developmental code name MIM-D3) is a selective, small-molecule partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.^[1]^[2]^[3] It was under development by Mimetogen Pharmaceuticals as an ophthalmic (eye drop) solution for the treatment of dry eyes, and reached phase III clinical trials for this indication. Tavilermide is currently being evaluated in two multi-center Phase 3 clinical studies in the United States for the treatment of dry eye disease.^[4][1] Tavilermide is also in phase I clinical trials for the treatment of glaucoma; studies are ongoing.^[5][2]

References

^ Meerovitch, Karen; Torkildsen, Gail; Lonsdale, John; Goldfarb, Heidi; Lama, Teresa; Cumberlidge, Garth; Ousler III, George W. (2013). "Safety and efficacy of MIM D3 ophthalmic solutions in a randomized placebo controlled Phase 2 clinical trial in patients with dry eye". Clinical Ophthalmology: 1275. doi:10.2147/OPTH.S44688. ISSN 1177-5483.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Jain, Pooja; Li, Ruihong; Lama, Teresa; Saragovi, H. Uri; Cumberlidge, Garth; Meerovitch, Karen (2011). "An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye". Experimental Eye Research. 93 (4): 503–512. doi:10.1016/j.exer.2011.06.014. ISSN 0014-4835.
^ Vickers, Laura A.; Gupta, Preeya K. (2015). "The Future of Dry Eye Treatment: A Glance into the Therapeutic Pipeline". Ophthalmology and Therapy. doi:10.1007/s40123-015-0038-y. ISSN 2193-8245.
^ Cite error: The named reference AllerganMimetogen2015 was invoked but never defined (see the help page).
^ Chang EE, Goldberg JL (2012). "Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement". Ophthalmology. 119 (5): 979–86. doi:10.1016/j.ophtha.2011.11.003. PMC 3343191. PMID 22349567.

External links

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

[MeerovitchTorkildsen2013-1] Meerovitch, Karen; Torkildsen, Gail; Lonsdale, John; Goldfarb, Heidi; Lama, Teresa; Cumberlidge, Garth; Ousler III, George W. (2013). "Safety and efficacy of MIM D3 ophthalmic solutions in a randomized placebo controlled Phase 2 clinical trial in patients with dry eye". Clinical Ophthalmology: 1275. doi:10.2147/OPTH.S44688. ISSN 1177-5483.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[JainLi2011-2] Jain, Pooja; Li, Ruihong; Lama, Teresa; Saragovi, H. Uri; Cumberlidge, Garth; Meerovitch, Karen (2011). "An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye". Experimental Eye Research. 93 (4): 503–512. doi:10.1016/j.exer.2011.06.014. ISSN 0014-4835.

[VickersGupta2015-3] Vickers, Laura A.; Gupta, Preeya K. (2015). "The Future of Dry Eye Treatment: A Glance into the Therapeutic Pipeline". Ophthalmology and Therapy. doi:10.1007/s40123-015-0038-y. ISSN 2193-8245.

[AllerganMimetogen2015-4] Cite error: The named reference AllerganMimetogen2015 was invoked but never defined (see the help page).

[pmid22349567-5] Chang EE, Goldberg JL (2012). "Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement". Ophthalmology. 119 (5): 979–86. doi:10.1016/j.ophtha.2011.11.003. PMC 3343191. PMID 22349567.

[1]

[2]

[3]

[4]

[5]

@@ Line 51: / Line 51: @@
 }}
-'''Tavilermide''' ([[International Nonproprietary Name|INN]]) (developmental code name '''MIM-D3''') is a selective, [[small-molecule]] [[partial agonist]] of [[TrkA]], or a [[nerve growth factor]] (NGF) [[mimetic]].<ref name="MeerovitchTorkildsen2013">{{cite journal|last1=Meerovitch|first1=Karen|last2=Torkildsen|first2=Gail|last3=Lonsdale|first3=John|last4=Goldfarb|first4=Heidi|last5=Lama|first5=Teresa|last6=Cumberlidge|first6=Garth|last7=Ousler III|first7=George W.|title=Safety and efficacy of MIM D3 ophthalmic solutions in a randomized placebo controlled Phase 2 clinical trial in patients with dry eye|journal=Clinical Ophthalmology|year=2013|pages=1275|issn=1177-5483|doi=10.2147/OPTH.S44688}}</ref><ref name="JainLi2011">{{cite journal|last1=Jain|first1=Pooja|last2=Li|first2=Ruihong|last3=Lama|first3=Teresa|last4=Saragovi|first4=H. Uri|last5=Cumberlidge|first5=Garth|last6=Meerovitch|first6=Karen|title=An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye|journal=Experimental Eye Research|volume=93|issue=4|year=2011|pages=503–512|issn=00144835|doi=10.1016/j.exer.2011.06.014}}</ref><ref name="VickersGupta2015">{{cite journal|last1=Vickers|first1=Laura A.|last2=Gupta|first2=Preeya K.|title=The Future of Dry Eye Treatment: A Glance into the Therapeutic Pipeline|journal=Ophthalmology and Therapy|year=2015|issn=2193-8245|doi=10.1007/s40123-015-0038-y}}</ref> It was under development by [[Mimetogen Pharmaceuticals]] as an [[ophthalmic solution|ophthalmic (eye drop) solution]] for the treatment of [[dry eyes]], and reached [[Phases of clinical research#Phase III|phase III]] [[clinical trial]]s for this indication, but development appears to have been halted.<ref name="MeerovitchTorkildsen2013" /><ref name="VickersGupta2015" />[http://adisinsight.springer.com/drugs/800033231] Tavilermide is also in [[Phases of clinical research#Phase I|phase I]] clinical trials for the treatment of [[glaucoma]]; studies are ongoing.<ref name="pmid22349567">{{cite journal | vauthors = Chang EE, Goldberg JL | title = Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement | journal = Ophthalmology | volume = 119 | issue = 5 | pages = 979–86 | year = 2012 | pmid = 22349567 | pmc = 3343191 | doi = 10.1016/j.ophtha.2011.11.003 | url = }}</ref>[http://adisinsight.springer.com/drugs/800033231]
+'''Tavilermide''' ([[International Nonproprietary Name|INN]]) (developmental code name '''MIM-D3''') is a selective, [[small-molecule]] [[partial agonist]] of [[TrkA]], or a [[nerve growth factor]] (NGF) [[mimetic]].<ref name="MeerovitchTorkildsen2013">{{cite journal|last1=Meerovitch|first1=Karen|last2=Torkildsen|first2=Gail|last3=Lonsdale|first3=John|last4=Goldfarb|first4=Heidi|last5=Lama|first5=Teresa|last6=Cumberlidge|first6=Garth|last7=Ousler III|first7=George W.|title=Safety and efficacy of MIM D3 ophthalmic solutions in a randomized placebo controlled Phase 2 clinical trial in patients with dry eye|journal=Clinical Ophthalmology|year=2013|pages=1275|issn=1177-5483|doi=10.2147/OPTH.S44688}}</ref><ref name="JainLi2011">{{cite journal|last1=Jain|first1=Pooja|last2=Li|first2=Ruihong|last3=Lama|first3=Teresa|last4=Saragovi|first4=H. Uri|last5=Cumberlidge|first5=Garth|last6=Meerovitch|first6=Karen|title=An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye|journal=Experimental Eye Research|volume=93|issue=4|year=2011|pages=503–512|issn=00144835|doi=10.1016/j.exer.2011.06.014}}</ref><ref name="VickersGupta2015">{{cite journal|last1=Vickers|first1=Laura A.|last2=Gupta|first2=Preeya K.|title=The Future of Dry Eye Treatment: A Glance into the Therapeutic Pipeline|journal=Ophthalmology and Therapy|year=2015|issn=2193-8245|doi=10.1007/s40123-015-0038-y}}</ref> It was under development by [[Mimetogen Pharmaceuticals]] as an [[ophthalmic solution|ophthalmic (eye drop) solution]] for the treatment of [[dry eyes]], and reached [[Phases of clinical research#Phase III|phase III]] [[clinical trial]]s for this indication. Tavilermide is currently being evaluated in two multi-center Phase 3 clinical studies in the United States for the treatment of dry eye disease.<ref name="AllerganMimetogen2015" />[http://www.streetinsider.com/Corporate+News/Allergan+%28AGN%29,+Mimetogen+Pharma+Enter+MIM-D3+D+Development+Collaboration/11033405.html] Tavilermide is also in [[Phases of clinical research#Phase I|phase I]] clinical trials for the treatment of [[glaucoma]]; studies are ongoing.<ref name="pmid22349567">{{cite journal | vauthors = Chang EE, Goldberg JL | title = Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement | journal = Ophthalmology | volume = 119 | issue = 5 | pages = 979–86 | year = 2012 | pmid = 22349567 | pmc = 3343191 | doi = 10.1016/j.ophtha.2011.11.003 | url = }}</ref>[http://adisinsight.springer.com/drugs/800033231]
 ==See also==
@@ Line 60: / Line 60: @@
 ==References==
-{{Reflist|2}}
+{{Reflist|3}}
 ==External links==
 * [http://www.mimetogen.com/clinical-development.html Clinical Development - Mimetogen Pharmaceuticals]
 * [http://adisinsight.springer.com/drugs/800033231 Tavilermide - AdisInsight]
+* [http://www.streetinsider.com/Corporate+News/Allergan+%28AGN%29,+Mimetogen+Pharma+Enter+MIM-D3+D+Development+Collaboration/11033405.html MIM-D3 StreetInsider]
 {{Antiglaucoma preparations and miotics}}